Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
3.5
Journals
Biology
Special Issues
Neurobiology of Traumatic Brain Injury
share announcement

Neurobiology of Traumatic Brain Injury

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 2801

Special Issue Editors

Dr. Ioannis Mavroudis

E-Mail
Guest Editor
1. Department of Neuroscience, Leeds Teaching Hospitals, NHS Trust, Leeds LS2 9JT, UK
2. Faculty of Medicine, Leeds University, Leeds LS2 9JT, UK
Interests: neuroanatomy; neuropathology; psychiatry; functional neurological disorders; traumatic brain injury; post-concussion syndrome; chronic traumatic encephalopathy; neurodegeneration; dementia
Special Issues, Collections and Topics in MDPI journals
Dr. Dimitrios A. Kazis

E-Mail Website
Guest Editor
Third Neurological Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: epilepsy; EEG in EMU/ICU; transcranial magnetic stimulation

Special Issue Information

Dear Colleagues, 

This Special Issue on "Neurobiology of Traumatic Brain Injury" aims to delve into the intricate mechanisms underlying traumatic brain injuries (TBIs) and their wide-ranging impacts on neural function and overall brain health. This Special Issue will encompass the latest research on the cellular and molecular pathways affected by TBIs, including neuroinflammation, neurodegeneration, and neuroplasticity. Additionally, it will explore the genetic and environmental factors that influence the recovery and development of chronic neurological conditions post-injury. We invite submissions that highlight innovative diagnostic tools, therapeutic strategies, and rehabilitation techniques designed to improve outcomes for patients with TBIs. By integrating multidisciplinary perspectives, this Special Issue seeks to enhance our understanding of TBIs and foster advancements in clinical practice and patient care.

Dr. Ioannis Mavroudis
Dr. Dimitrios A. Kazis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatic brain injury (TBI)
  • neuroinflammation
  • neuroplasticity
  • neurodegeneration
  • molecular pathways
  • genetic factors
  • diagnostic tools
  • therapeutic strategies
  • rehabilitation techniques
  • chronic neurological conditions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

Jump to: Other

23 pages, 411 KiB  
Review
Neurobiology of Chronic Pain, Posttraumatic Stress Disorder, and Mild Traumatic Brain Injury
by Gerald Young, Hella Thielen, Kristin Samuelson and Joel Jin
Biology 2025, 14(6), 662; https://doi.org/10.3390/biology14060662 - 7 Jun 2025
Viewed by 746
Abstract
Objectives: This article describes the neurobiology of psychological injuries—chronic pain, concussion/mild traumatic brain injury (MTBI), and fear/posttraumatic stress disorder (PTSD)—toward elucidating common mechanisms in central and peripheral sensitization that contribute to their onset, exacerbation, and maintenance. Central sensitization refers to central nervous system [...] Read more.
Objectives: This article describes the neurobiology of psychological injuries—chronic pain, concussion/mild traumatic brain injury (MTBI), and fear/posttraumatic stress disorder (PTSD)—toward elucidating common mechanisms in central and peripheral sensitization that contribute to their onset, exacerbation, and maintenance. Central sensitization refers to central nervous system (CNS) and related processes, while peripheral sensitization is typically referred to as receptor field expansion. The three psychological injury diagnoses/conditions are accompanied by impairments in function after negligent events (such as motor vehicle accidents (MVAs)) that lead to tort court action. Methods: The conducted literature review involved an extensive scoping review of recent neurobiological literature on chronic pain, PTSD, and MTBI. The literature review sought biological markers that distinguish them. Results: For chronic pain, concussion/MTBI, and fear/PTSD, this article reviewed definitions and critical neurobiological research. The literature review did not find evidence of biological markers, but the role of sensitization emerged as important. Conclusions: Common therapeutic processes, such as focusing on sensitization, might be helpful for these conditions. As for causal mechanisms related to sensitization in the causality of psychological injuries, the major ones hypothesized relate to the biopsychosocial model, psychological control, and activation–inhibition coordination. Full article
(This article belongs to the Special Issue Neurobiology of Traumatic Brain Injury)
►▼ Show Figures

Figure 1

Other

Jump to: Review

17 pages, 1810 KiB  
Systematic Review
Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis
by Zeeshan A. Khan, Tahiris A. Duran, Dewan Md. Sumsuzzman, Ling-Sha Ju, Christoph N. Seubert and Anatoly E. Martynyuk
Biology 2025, 14(6), 640; https://doi.org/10.3390/biology14060640 - 31 May 2025
Viewed by 556
Abstract
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We [...] Read more.
Accelerated neurocognitive decline associated with surgeries under general anesthesia (GA), a phenomenon referred to as postoperative neurocognitive disorder (PND), is a significant public health concern. It not only poses inherent risks but may also contribute to the development of other neurodegenerative disorders. We systematically searched five databases for studies examining cognitive function in patients with mild-to-moderate TBI with (participant) or without (control) subsequent extracranial surgeries/GA. A random effects model was applied to calculate mean differences (MDs) and 95% confidence intervals (CIs). Five outcomes were analyzed post hoc: trail-making tests A and B (TMT-A/B), Glasgow Outcome Scale–Extended (GOSE), and length of stay (LOS) in intensive care units (ICUs) and hospitals. Five studies met the criteria for our meta-analysis. Patients with a history of mild-to-moderate TBI who underwent extracranial surgeries/GA exhibited worse outcomes in TMT-A [MD = 2.04; CI 0.38–3.70; p = 0.016] and TMT-B [MD = 16.59; CI 9.58–23.60; p < 0.001]. Differences in the ICU and hospital LOS and GOSE between the study groups were insignificant. Our results suggest that extracranial surgeries/GA may worsen neurocognitive outcomes without affecting functional recovery in mild-to-moderate TBI patients. Given the limited number of studies identified and the high incidence of TBI, more research on PND in TBI patients is warranted. Full article
(This article belongs to the Special Issue Neurobiology of Traumatic Brain Injury)
►▼ Show Figures

Graphical abstract

9 pages, 211 KiB  
Protocol
Perioperative Neurocognitive Disorder in Individuals with a History of Traumatic Brain Injury: Protocol for a Systematic Review and Meta-Analysis
by Zeeshan Ahmad Khan, Dewan Md. Sumsuzzman, Tahiris A. Duran, Ling-Sha Ju, Christoph N. Seubert and Anatoly E. Martynyuk
Biology 2025, 14(2), 197; https://doi.org/10.3390/biology14020197 - 13 Feb 2025
Cited by 1 | Viewed by 1017
Abstract
Postoperative neurocognitive disorder (PND) is a cognitive decline after general anesthesia and surgery, influenced by preexisting neurodegenerative conditions, stress, and inflammation. Traumatic brain injury (TBI) is linked to a dysregulated stress response, neuroinflammation, and cognitive issues. Patients with TBI often need extracranial surgeries [...] Read more.
Postoperative neurocognitive disorder (PND) is a cognitive decline after general anesthesia and surgery, influenced by preexisting neurodegenerative conditions, stress, and inflammation. Traumatic brain injury (TBI) is linked to a dysregulated stress response, neuroinflammation, and cognitive issues. Patients with TBI often need extracranial surgeries under general anesthesia (GA), which can increase stress, neuroinflammation, and neurodegenerative changes, raising PND risk. We will search databases like Ovid Medline and Embase for studies on cognitive function in patients with mild to moderate TBI who had extracranial surgeries under general anesthesia (GA). Screening and data extraction will be done manually and with AI-assisted tools (ASReview). Study quality will be assessed using the Newcastle–Ottawa Scale. Statistical analyses will include mean differences, odds ratios, and meta-regression, addressing heterogeneity, sensitivity, and publication bias using Stata/SE. By meta-analyzing clinical studies, we aim to determine if TBI and GA/surgery interact to induce PND. We will use various data sources, subgroup analyses, sensitivity analyses, and meta-regression to assess factors like age, gender, and type of GA/surgery. This meta-analysis will enhance our understanding of PND risks, inform clinical practices, and highlight new research directions. The systematic review is registered in PROSPERO (CRD42024510980). Full article
(This article belongs to the Special Issue Neurobiology of Traumatic Brain Injury)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop