Pathobiology of Cardiac Arrhythmias and Heart Failure Issues

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 384

Special Issue Editor


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Guest Editor
Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA
Interests: atrial fibrillation; cardiomyopathy; heart failure; cell signaling; gene therapy

Special Issue Information

Dear Colleagues,

Cardiac arrhythmias and heart failure are major contributors to global morbidity and mortality. Research in this field aims to understand the mechanisms of electrical and structural dysfunction in the heart. This knowledge supports the development of diagnostic tools, pharmacological treatments, and advanced therapies, such as implantable devices and gene-based interventions. Advancements improve patient outcomes, reduce healthcare burdens, and address unmet clinical needs. With growing populations and aging demographics, innovative research remains critical in combating these life-threatening conditions and improving quality of life for millions worldwide.

We are pleased to invite you to contribute to a Special Issue of Biology focusing on the “Pathobiology of Cardiac Arrhythmias and Heart Failure Issues”. This Special Issue aims to explore the molecular, cellular, and systemic mechanisms underlying these conditions, alongside innovative diagnostics and therapeutic strategies. This Special Issue aligns with Biology’s aims and scope to advance biological science through rigorous, impactful research. Join us in enriching this critical field!

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: ion channelopathies, fibrosis, apoptosis, inflammation, metabolic dysregulation, and the interplay of genetic and environmental factors.

I look forward to receiving your contributions.

Dr. Mohit Hulsurkar
Guest Editor

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Keywords

  • cardiac arrhythmias
  • atrial fibrillation
  • heart failure
  • ion channelopathy
  • cardiac fibrosis
  • cardiomyopathy

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Published Papers (1 paper)

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Research

12 pages, 280 KiB  
Article
TRIB1 and TRPS1 Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations
by Gilberto Vargas-Alarcón, Óscar Pérez-Méndez, Rosalinda Posadas-Sánchez, Héctor González-Pacheco, Teresa Juárez-Cedillo, Galileo Escobedo, Victoria López-Olmos and José Manuel Fragoso
Biology 2025, 14(6), 606; https://doi.org/10.3390/biology14060606 - 26 May 2025
Viewed by 215
Abstract
In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (TRPS1) and tribbles pseudokinase 1 (TRIB1) play an important role in plasma lipid profiles and act as risk [...] Read more.
In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (TRPS1) and tribbles pseudokinase 1 (TRIB1) play an important role in plasma lipid profiles and act as risk factors for coronary heart disease (CHD). The aim of this work was to explore whether single nucleotide polymorphisms (SNPs) in the TRSP1 (rs231150 and rs2737229) and TRIB1 (rs2980880 and rs2954029) genes are involved in acute coronary syndrome (ACS) and plasma lipid levels. We included 1262 patients diagnosed with ACS and 1051 controls. According to inheritance models, the minor alleles of the SNPs (rs2737229 A, rs2980880 C, and rs2954029 T) were associated with an increased incidence of ACS (p < 0.05). In a sub-analysis that included only the control subjects, the same minor allele frequency was associated with increased total cholesterol, HDL-cholesterol, and LDL-cholesterol levels and low triglyceride levels. In conclusion, rs2737229, rs2980880, and rs2954029 polymorphisms are associated with a risk of developing ACS and with elevated plasma lipid levels. Our results suggest that the TRSP1 and TRIB1 are implicated in the incidence of ACS through of increased of plasma lipid profile. Full article
(This article belongs to the Special Issue Pathobiology of Cardiac Arrhythmias and Heart Failure Issues)
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