Biology of Obstructive Sleep Apnea and Cancer

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1947

Special Issue Editors


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Guest Editor
Sleep Medicine Center, Department of Otolaryngology, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
Interests: head and neck cancer; sleep; sleep apnea; olfaction; biologicals; allergy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Sleep Medicine Center, Department of Otorhinolaryngology, Medical Center of the University of Mainz, 55131 Mainz, Germany
Interests: hypoxia; taste; olfaction; hearing; head and neck; sleep; sleep apnea; clinical
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obstructive sleep apnea (OSA) is a highly prevalent disease affecting almost 50% of the male and almost 25% of the female adult population in Western Europe, with similar figures seen worldwide. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 according to the WHO. A connection between these two entities has been postulated for years, with the literature on an association between obstructive sleep apnea (OSA) and cancer gaining momentum in the last few years. More and more malignant entities are being associated with OSA in small cohort or case control studies as well as in large population-based studies. Future studies should further corroborate these findings, focus on effects of treatment of OSA on cancer morbidity as well as mortality, and give insights into underlying molecular mechanisms of the association.

For this Special Issue, “Biology of Obstructive Sleep Apnea and Cancer”, we invite submissions of original articles and review articles to cover recent basic and translational research  involving the study of possible links between various cancer entities and OSA. The aim is to highlight and promote awareness on this matter in the scientific community and hence accelerate relevant research.

You may choose our Joint Special Issue in Medicina.

Dr. Tilman Huppertz
Prof. Dr. Haralampos Gouveris
Guest Editors

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Keywords

  • obstructive sleep apnea
  • hypopnea
  • hypoxia
  • cancer
  • tumor
  • carcinoma
  • lymphoma
  • quality of life
  • sleep quality
  • metabolism
  • cardiorespiratory home sleep apnea testing
  • polysomnography
  • smoking and alcohol consumption

Published Papers (1 paper)

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Research

9 pages, 650 KiB  
Article
Insomnia in Patients Undergoing Hypoglossal Nerve Stimulation Therapy for Obstructive Sleep Apnea
by Johannes Pordzik, Katharina Ludwig, Christopher Seifen, Tilman Huppertz, Katharina Bahr-Hamm, Christoph Matthias and Haralampos Gouveris
Biology 2023, 12(1), 98; https://doi.org/10.3390/biology12010098 - 09 Jan 2023
Cited by 2 | Viewed by 1396
Abstract
Hypoglossal nerve stimulation (HGNS) is a treatment for obstructive sleep apnea (OSA) patients with intolerance of positive airway pressure therapy. Comorbid insomnia is quite prevalent in OSA patients. We investigated the impact of insomnia and excessive daytime sleepiness (EDS) on polysomnography metrics after [...] Read more.
Hypoglossal nerve stimulation (HGNS) is a treatment for obstructive sleep apnea (OSA) patients with intolerance of positive airway pressure therapy. Comorbid insomnia is quite prevalent in OSA patients. We investigated the impact of insomnia and excessive daytime sleepiness (EDS) on polysomnography metrics after HGNS treatment. Data of 27 consecutive patients (9 female; mean age 55.52 ± 8.6 years) were retrospectively evaluated. Insomnia was assessed using the ISI (insomnia severity index) and EDS using the Epworth sleepiness scale (ESS). The median ISI was reduced significantly 3 months after HGNS activation (preoperative: 19; postoperative: 14; p < 0.01). Significant correlations emerged between preoperative ISI and postoperative AHI (apnea/hypopnea index; Spearman’s rho = 0.4, p < 0.05), ∆ AHI (r = −0.51, p < 0.01) and ∆ ODI (oxygen desaturation index; r = −0.48, p < 0.05). ISI correlated strongly with EES both preoperatively (r = 0.46; p < 0.02) and postoperatively (r = 0.79; p < 0.001). Therefore, HGNS therapy is associated with a significant reduction of insomnia-related symptoms, in addition to the improvement in respiratory metrics in OSA. Nonetheless, the preoperative severity of patient-reported insomnia symptoms was inversely correlated with the respiratory PSG-outcomes after HGNS. Insomnia should be considered in studies of EDS in OSA patients, especially those treated with HGNS. Full article
(This article belongs to the Special Issue Biology of Obstructive Sleep Apnea and Cancer)
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