Soft Tissue Reconstruction and Repair

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 October 2026

Special Issue Editor


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Guest Editor
Center for Experimental Surgery, Biomedical Research Foundation, Academy of Athens, Athens, Greece
Interests: experimental surgery; surgical research; regenerative surgery-medicine; biomaterial and biofabrication preclinical research; animal models for novel surgical techniques; drugs and devices; microsurgery; biomedical research; graft; from the idea to clinical phase one
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Special Issue Information

Dear Colleagues,

Soft tissue reconstruction and repair encompasses wound healing, cosmetic and functional restoration of muscles, adipose tissue, fascia, dermis, tendons, and related supporting structures. A central challenge across these tissues is establishing rapid, stable vascularization to supply nutrients, clear metabolites, and immune surveillance, while preserving or restoring mechanical integrity and correct tissue architecture. This Special Issue, ‘Soft Tissue Reconstruction and Repair’, invites advances in biomaterials, biofabrication, and translational strategies that explicitly address vascularization, perfusion, and integration with host tissues to achieve durable functional outcomes.

Contributions should illuminate the design, synthesis, and processing of biomaterials and scaffolds (natural, synthetic, or hybrid) that promote angiogenesis/vasculogenesis, support resident and recruited cell populations (e.g., myocytes, adipocytes, fibroblasts, endothelial cells, pericytes, immune cells), and guide tissue remodeling without excessive fibrosis. Topics of interest include, but are not limited to, biocompatible polymers, natural and decellularized matrices, hydrogels and elastomeric networks, bioactive ceramics, and composite materials; fabrication and biofabrication approaches such as 3D bioprinting, electrospinning, electrohydrodynamic deposition, decellularization/recellularization, and injectable or minimally invasive strategies; and delivery of pro-angiogenic cues, growth factors, cells, or exosomes to accelerate vascular integration.

This Special Issue welcomes original research, reviews, methodology papers, and perspectives that connect material science with surgical repair and clinical translation, spanning acute injuries to chronic soft tissue defects. By integrating vascular-aware biomaterial design with cellular and molecular drivers of regeneration, this collection aims to accelerate the development of effective, patient-specific soft tissue reconstruction therapies.

Dr. Michalis P. Katsimpoulas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascularization
  • soft tissue reconstruction
  • biomaterials
  • tissue engineering
  • hydrogels

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Published Papers

This special issue is now open for submission.
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