Trends in Vascular Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 354

Special Issue Editors


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Guest Editor
Center of Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, 115 27 Athens, Greece
Interests: vascular bypass surgery; tissue-engineering; vascular grafts; regenerative medicine; stem cells; exosomes; iPSCs
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Guest Editor
Department of Biomedical Engineering, Cullen College of Engineering, The University of Houston, Houston, TX 77204, USA
Interests: cardiovascular medicine; drug delivery system design; systems and control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vascular disorders, including coronary artery disease (CAD), peripheral artery disease (PAD), cerebrovascular disease (CeVD), and rheumatic heart disease (RHD), represent the leading cause of morbidity and mortality worldwide. Specifically, more than 17 million people die due to complications of vascular disease each year, in which time more than 800,000 bypass surgeries are performed.

Vascular tissue engineering has gained significant attention in the field of biomedical research as a promising approach for treating vascular diseases. This cutting-edge area focuses on developing functional vascular tissues to replace or repair damaged blood vessels.

This Special Issue aims to showcase the latest advancements, breakthroughs, and innovations in the field of vascular tissue engineering and regenerative medicine. We invite researchers, scientists, and professionals from around the world to submit their original research papers, review articles, and short communications for consideration.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Vascularization strategies and novel concepts;
  • Stem cells in vascular tissue engineering;
  • Biomaterials in vascular tissue engineering;

Novel techniques and technologies, such as 3D bioprinting, microfluidic systems, gene editing tools, and tissue-on-a-chip platforms, advancing vascular tissue engineering and regenerative medicine.

Dr. Michalis P. Katsimpoulas
Dr. Yuncheng Du
Guest Editors

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Keywords

  • cardiovascular disease
  • 3D bioprinting
  • vascular grafts
  • stem cells
  • scaffolds

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Published Papers (1 paper)

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Review

22 pages, 924 KB  
Review
Advances in Innovative Surgical Implant Manufacturing for Hernia Repair and Soft Tissue Reconstruction
by Stavros Patsouris, Panagiotis Mallis, Efstathios Michalopoulos, Nikolaos Nikiteas, Nefeli Papadopoulou and Michalis Katsimpoulas
Bioengineering 2025, 12(11), 1182; https://doi.org/10.3390/bioengineering12111182 - 30 Oct 2025
Abstract
Abdominal wall hernias occur in a high percentage of the general population, making prosthetic hernia repair one of the most common surgical procedures. Despite the significant development of surgical techniques and the improvement of surgical meshes, complications still burden the health of patients, [...] Read more.
Abdominal wall hernias occur in a high percentage of the general population, making prosthetic hernia repair one of the most common surgical procedures. Despite the significant development of surgical techniques and the improvement of surgical meshes, complications still burden the health of patients, as well as the health system. The successful integration of the mesh plays a crucial role in the minimizing the complications associated with hernia meshes. Regenerative medicine focuses on the development of new treatments and applications to heal tissues and organs in order to restore their function. It uses scaffolds that provide physical support and a suitable environment for accelerating repair and proliferation and promoting the regeneration of damaged tissue. Platelet-rich plasma and stem cells are essential tools in regenerative medicine since they have shown efficacy in multiple fields. The main risk factor negatively affecting the survival of any cell type, including stem cells on a prosthetic material, is ischemia. Without the minimum required supply of oxygen, growth factors, and cytokines, it is impossible for cells to successfully proliferate and differentiate. The addition of PRP to a surgical mesh is hypothesized to increase neoangiogenesis in the area, acting as a reservoir of growth factors that will create the right conditions for the proliferation and differentiation of these cells. The aim of the present review is to record experimental studies that have been published where a scaffold or a hernia mesh is coated with PRP, stem cells, or a combination of them for hernia repair and soft tissue reconstruction. Full article
(This article belongs to the Special Issue Trends in Vascular Tissue Engineering)
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