Large Language Models: Theories, Methodologies and Real-World Applications in Healthcare

A special issue of Applied System Innovation (ISSN 2571-5577). This special issue belongs to the section "Medical Informatics and Healthcare Engineering".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 161

Special Issue Editor

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Guest Editor
Department of Mathematical, Physical and Computer Sciences, University of Parma, 43124 Parma, Italy
Interests: big data; data analysis; health data analysis; data mining; information retrieval; machine learning; deep learning
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, large language models (LLMs) have undergone a remarkable evolution, transforming the landscape of natural language processing. As these models advanced, their ability to understand context, generate coherent text, and even perform reasoning tasks improved significantly, leading to their integration into various sectors of society. In particular, in the healthcare domain, LLMs hold immense promise. Their proficiency in understanding and generating human-like text enables them to analyse complex medical literature, stay updated on the latest research, and assist healthcare professionals in carrying out mass screening of high-impacting diseases. These models could aid in extracting valuable insights from patient records, suggesting potential diagnoses based on symptoms, and even assisting in the interpretation of medical data. This Special Issue invites submissions of scientific findings that showcase foundational theories, methodologies, real-world applications of LLMs in healthcare, and also future strategic plans.

Dr. Flavio Bertini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied System Innovation is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • artificial intelligence in healthcare
  • LLMs in healthcare
  • fine-tuning LLMs for screening
  • LLMs for medical knowledge retrieval
  • explanations of LLMs for healthcare applications

Published Papers

This special issue is now open for submission.
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