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Women in Oral Medicine, Oral Biology, Oral Microbiology and Oral Bioengineering

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 18166

Special Issue Editors


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Guest Editor
Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania L. Vanvitelli, Naples, Italy
Interests: oral microbiome; oral microbiota; disbiosis; oral pathology and medicine; pediatric dentistry; dentistry; oral cancer; oral infections; oral mycology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy
Interests: microbiology; bacteria; fungi; biofilm; host-pathogen interactions; innate immunityantimicrobial peptides; microbiota; probiotics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy
Interests: dentistry; oral medicine; oral pathology; oral immunology; imaging in oral diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing presence of female researchers in the scientific areas of medicine, dentistry, biology, and bioengineering, in parallel with the development of personalized gender medicine and the evident biological differences between genders, has prompted us to create this Special Issue on “Women in Oral Medicine, Oral Biology, Oral Microbiology, and Oral Bioengineering”.

The purpose of this Special Issue—for women and on women—is to collect high-quality original research articles and reviews on the topic of “Women in Oral Medicine, Oral Biology, Oral Microbiology and Oral Bioengineering”. Contributions by research groups led by women or men are expected, and we encourage articles in which women are the first author or one of the corresponding authors and where the topic is about gender differences related to medical, dental, biological, and biotechnological aspects.

We are confident that the scientific community will participate enthusiastically in this initiative.

We look forward to receiving your contributions.

Dr. Maria Contaldo
Dr. Alessandra Fusco
Prof. Dr. Alberta Lucchese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medical product development
  • healthcare technology
  • diagnostic devices
  • imaging in oral medicine
  • medical and dental diagnostic techniques
  • gender medicine
  • systematic reviews and meta-analysis
  • oral microbiome and microbiota
  • potentially malignant disorders and oral carcinoma
  • diagnosis and treatment of oral diseases
  • oral manifestations in patients with systemic diseases
  • new technologies in dentistry and oral medicine
  • skin microbiota
  • intestinal microbiota

Published Papers (5 papers)

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Review

11 pages, 670 KiB  
Review
Why Is Multiple Sclerosis More Frequent in Women? Role of the Immune System and of Oral and Gut Microbiota
by Marianna D’Anca, Francesca R. Buccellato, Gianluca Martino Tartaglia, Massimo Del Fabbro, Paola Muti, Elio Scarpini, Daniela Galimberti and Laura Ghezzi
Appl. Sci. 2023, 13(10), 5881; https://doi.org/10.3390/app13105881 - 10 May 2023
Viewed by 1891
Abstract
Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system (CNS) with an autoimmune component affecting young adults in their third decade of life. The etiology is still undefined, but myelin damage is mainly due to an aberrant immune [...] Read more.
Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system (CNS) with an autoimmune component affecting young adults in their third decade of life. The etiology is still undefined, but myelin damage is mainly due to an aberrant immune response of lymphocyte cells against myelin components. Therefore, inflammation, demyelination, and axonal degeneration represent the major pathologic hallmarks of the disease. There are many risk factors associated with MS, and probably the most relevant is gender-related. Women are up to four times more affected than men are. Although the female prevalence in MS is epidemiologically evident, the identification of key factors involved in this difference is under investigation. On the other side, if women are more affected, men show late onset and worse prognosis. This sexual dimorphism derives from many sources, including sex hormones, different genes on female sex chromosomes, and differences in bacterial species. Indeed, accumulating evidence proves a link among MS and gut microbiota where its dysbiosis could help the immune system to trigger neuroinflammation. In this context, oral biology alteration should be considered, too. This work is intended to explore current knowledge inside MS gender differences with a look towards oral–gut–brain axis involvement. Full article
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15 pages, 853 KiB  
Review
Analysis of Risk Factors of Oral Cancer and Periodontitis from a Sex- and Gender-Related Perspective: Gender Dentistry
by Federica Di Spirito, Alessandra Amato, Antonio Romano, Gianna Dipalma, Edit Xhajanka, Adone Baroni, Rosario Serpico, Francesco Inchingolo and Maria Contaldo
Appl. Sci. 2022, 12(18), 9135; https://doi.org/10.3390/app12189135 - 12 Sep 2022
Cited by 8 | Viewed by 2666
Abstract
Gender-specific medicine studies how sexual biology and gender-related cultural and behavioral differences may influence a person’s health and considers the differences in clinical features, prevention, therapies, prognosis, and psycho-social aspects of diseases with different impacts on women and men. The present work summarizes [...] Read more.
Gender-specific medicine studies how sexual biology and gender-related cultural and behavioral differences may influence a person’s health and considers the differences in clinical features, prevention, therapies, prognosis, and psycho-social aspects of diseases with different impacts on women and men. The present work summarizes the main differential impact each risk factor for oral cancer and periodontitis has according to biological sex- and gender-oriented differences. It resulted in differences in epidemiology and the weight of various healthy determinants that may influence the incidence and prognosis of oral cancer and periodontitis. It is desirable to change the methodology of scientific studies with a higher focus on the weight that sexual variables may have on the well-being or the probability of getting ill of each person, thus promoting the development and diffusion of personalized gender dentistry. Full article
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20 pages, 392 KiB  
Review
Non-Plaque Induced Diffuse Gingival Overgrowth: An Overview
by Domenico De Falco, Fedora Della Vella, Michele Scivetti, Carmela Suriano, Michele De Benedittis and Massimo Petruzzi
Appl. Sci. 2022, 12(8), 3731; https://doi.org/10.3390/app12083731 - 7 Apr 2022
Cited by 2 | Viewed by 3599
Abstract
Non-plaque induced diffuse gingival overgrowth represents a broad class of conditions caused by several etiological factors. The aim of this review is to highlight the most recent updates and classifications of all the existent gingival overgrowths. In addition, we highlighted the diagnostic pathway [...] Read more.
Non-plaque induced diffuse gingival overgrowth represents a broad class of conditions caused by several etiological factors. The aim of this review is to highlight the most recent updates and classifications of all the existent gingival overgrowths. In addition, we highlighted the diagnostic pathway that should be employed in patients affected by gingival overgrowth. Gingival overgrowth can be related to syndromic diseases including a wide spectrum of genetic and chromosomal alterations. However, thanks to scientific sharing and the availability of genetic panels it is possible to obtain an accurate phenotypic identification of well-known syndromes and also to identify new ones. This narrative review shows that through rigid, strict diagnostic protocols, the work of the clinician is greatly facilitated, despite the wide variety of pathologies considered. In conclusion, the exchange of specialists’ competencies and the multidisciplinary management of these patients, are crucial to reach diagnosis and the correct clinical-therapeutic management. Full article
42 pages, 7185 KiB  
Review
Poly(lactic acid)-Based Electrospun Fibrous Structures for Biomedical Applications
by Homa Maleki, Bahareh Azimi, Saeed Ismaeilimoghadam and Serena Danti
Appl. Sci. 2022, 12(6), 3192; https://doi.org/10.3390/app12063192 - 21 Mar 2022
Cited by 51 | Viewed by 6658
Abstract
Poly(lactic acid)(PLA) is an aliphatic polyester that can be derived from natural and renewable resources. Owing to favorable features, such as biocompatibility, biodegradability, good thermal and mechanical performance, and processability, PLA has been considered as one of the most promising biopolymers for biomedical [...] Read more.
Poly(lactic acid)(PLA) is an aliphatic polyester that can be derived from natural and renewable resources. Owing to favorable features, such as biocompatibility, biodegradability, good thermal and mechanical performance, and processability, PLA has been considered as one of the most promising biopolymers for biomedical applications. Particularly, electrospun PLA nanofibers with distinguishing characteristics, such as similarity to the extracellular matrix, large specific surface area and high porosity with small pore size and tunable mechanical properties for diverse applications, have recently given rise to advanced spillovers in the medical area. A variety of PLA-based nanofibrous structures have been explored for biomedical purposes, such as wound dressing, drug delivery systems, and tissue engineering scaffolds. This review highlights the recent advances in electrospinning of PLA-based structures for biomedical applications. It also gives a comprehensive discussion about the promising approaches suggested for optimizing the electrospun PLA nanofibrous structures towards the design of specific medical devices with appropriate physical, mechanical and biological functions. Full article
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12 pages, 10410 KiB  
Review
S-Adenosylmethionine, a Promising Antitumor Agent in Oral and Laryngeal Cancer
by Laura Mosca, Francesca Vitiello, Martina Pagano, Alessandra Coppola, Roberta Veglia Tranchese, Roberta Grillo, Giovanna Cacciapuoti and Marina Porcelli
Appl. Sci. 2022, 12(3), 1746; https://doi.org/10.3390/app12031746 - 8 Feb 2022
Cited by 3 | Viewed by 2218
Abstract
Squamous cell carcinoma of the head and neck (HNSCC), which includes cancers of the oral cavity and larynx, is one of the most common and highly aggressive malignancies worldwide, despite significant efforts committed in recent decades in its detection, prevention, and treatment. The [...] Read more.
Squamous cell carcinoma of the head and neck (HNSCC), which includes cancers of the oral cavity and larynx, is one of the most common and highly aggressive malignancies worldwide, despite significant efforts committed in recent decades in its detection, prevention, and treatment. The intrinsic or acquired drug resistance during treatment is the main limitation to chemotherapy, increasing mortality and cancer recurrence. Therefore, there is a growing scientific interest in identifying and developing adjuvant chemotherapies able to improve currently available treatments. S-Adenosylmethionine (AdoMet), a safe and nontoxic natural cofactor with pleiotropic effects on multiple cellular processes and the main biological methyl donor in transmethylation reactions, has been considerably studied as a therapeutic compound. Its application, alone or in combination with other drugs, is emerging as a potentially effective strategy for cancer treatment and for chemoprevention. This review summarizes the structural, pharmacological, and clinical aspects of AdoMet and provides an overview of the recent results highlighting its anticancer activity in the treatment of oral and laryngeal cancer, with particular emphasis on its molecular mechanisms and the promising chemoprotective and synergistic effects exerted in combination with cisplatin and specific microRNAs. Full article
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