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Advanced Technologies for Digital Dentistry and Oral and Maxillofacial Reconstruction

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 857

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Manufacturing Engineering Department, Faculty of Industrial Engineering and Robotics, National University of Science and Technology Politehnica Bucharest, Splaiul Independenței 313, 060042 București, Romania
Interests: computer-aided design; parametric design; spur gear pumps; prototyping; special devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Digital transformation is reshaping the entire spectrum of oral healthcare from preventive and restorative dentistry to complex oral and maxillofacial reconstruction using cutting-edge methodologies. Contemporary innovations such as high-resolution imaging, digital workflow integration, artificial intelligence, parametric 3D modeling, additive manufacturing, customized biomaterials, surgical navigation, and virtual planning platforms are creating new possibilities for precision medicine and personalized rehabilitation.

This Special Issue seeks high-quality contributions on advanced technologies that support diagnosis, planning, fabrication, surgery, and outcome assessment in digital dentistry and oral and maxillofacial reconstruction. Relevant themes include the advanced use of CAD/CAM systems, 3D facial and intraoral data acquisition, implant planning, guided bone regeneration, customized creation of plates and implants, patient-specific surgical guides, biomechanical modeling, digital occlusion analysis, smart materials, bioprinting, and AI-assisted decision support. Studies evaluating clinical efficacy, workflow optimization, long-term performance, and challenges in implementation are encouraged.

The goal of this Special Issue is to provide ideas for and a comprehensive platform to achieve interdisciplinary research and innovation that bridges engineering and clinical science and that advances the future of precise, efficient, and individualized oral and maxillofacial care.

Prof. Dr. Corina Marilena Cristache
Dr. Ionut Gabriel Ghionea
Guest Editors

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Keywords

  • digital dentistry
  • oral and maxillofacial reconstruction
  • CAD/CAM
  • 3D printing
  • artificial intelligence
  • virtual surgical planning
  • patient-specific implants
  • guided surgery
  • biomaterials
  • tissue engineering
  • cone-beam computed tomography
  • digital workflow
  • bioprinting
  • smart biomaterials
  • finite element analysis

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Published Papers (1 paper)

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Research

13 pages, 3358 KB  
Article
Surface Biofunctionalization of Additively Manufactured Medical-Grade PEEK by GelMA Grafting for Maxillofacial Reconstruction
by Andrada Serafim, Mircea Alexandru Cristache, Elena Olareț, Eduard Liciu, Ionut Gabriel Ghionea, Cristina Busuioc, Izabela-Cristina Stancu and Corina Marilena Cristache
Appl. Sci. 2026, 16(16), 8126; https://doi.org/10.3390/app16168126 - 14 Aug 2026
Viewed by 237
Abstract
Polyetheretherketone (PEEK) is increasingly attractive for patient-specific maxillofacial reconstruction because its elastic modulus approximates cortical bone, it is fully radiolucent, and it is compatible with additive manufacturing; its principal limitation is bioinertness, as the hydrophobic surface does not support protein adsorption or direct [...] Read more.
Polyetheretherketone (PEEK) is increasingly attractive for patient-specific maxillofacial reconstruction because its elastic modulus approximates cortical bone, it is fully radiolucent, and it is compatible with additive manufacturing; its principal limitation is bioinertness, as the hydrophobic surface does not support protein adsorption or direct bone apposition. This study aimed to functionalize the surface of fused-deposition-modeling (FDM)-printed, medical-grade PEEK to increase its potential for bioactivity while preserving these bulk advantages. To this end, 3D-printed specimens of implant-grade PEEK were activated by CO2 plasma and coated with gelatin methacryloyl (GelMA) via EDC/NHS coupling followed by UV photocrosslinking. Surfaces were characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy, sessile-drop water contact angle measurement, gravimetric analysis, and scanning electron microscopy (SEM). Plasma treatment introduced oxygen-containing functional groups and reduced the water contact angle from 78.3° to 6.6°. GelMA deposition following EDC/NHS coupling, consistent with covalent immobilization, was supported by characteristic amide bands and was most pronounced for the 50 mg/mL formulation, corresponding to a deposited mass of 11.81 ± 0.47 μg/mm2; SEM revealed a relatively uniform protein film along the printed filaments. These results establish a surface-functionalization route and provide preliminary physicochemical indicators of potential bioactivity for patient-specific PEEK implants, to be confirmed through in vitro and in vivo biological validation. Full article
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