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Applied Sciences
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Editorial Board Members’ Collection Series: Dental and Biological Materials
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Editorial Board Members’ Collection Series: Dental and Biological Materials

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 7719

Special Issue Editor

Dr. Mary Anne Melo

E-Mail Website
Guest Editor
Department of General Dentistry, University of Maryland School of Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA
Interests: oral biofilm; dental materials; dental caries; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a new Special Issue, entitled “Editorial Board Members’ Collection Series: Dental and Biological Materials”, which will be a collection of papers invited for publication by the Editorial Board Members.

This Special Issue aims to collect high-quality articles and the latest research results in the field of dental and biological materials and to provide a platform for networking and communication among scholars in the field of Oral Sciences. These materials include dental composites, nanocomposites, sealants, bonding agents, cements, etc. All papers will be fully open access upon publication after peer review.

Dr. Mary Anne Melo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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18 pages, 3515 KiB  
Article
Effects of Physically Adsorbed and Chemically Immobilized RGD on Cell Adhesion to a Hydroxyapatite Surface
by Melissa Leitão, Elena Mavropoulos, Marcia Soares Sader, Andrea Costa, Elvis Lopez, Giselle Nogueira Fontes, José Mauro Granjeiro, Tea Romasco, Natalia Di Pietro, Adriano Piattelli, Carlos Fernando Mourão, Gutemberg Gomes Alves and Alexandre Malta Rossi
Appl. Sci. 2024, 14(17), 7479; https://doi.org/10.3390/app14177479 - 23 Aug 2024
Cited by 2 | Viewed by 1225
Abstract
The strategies used to associate peptide arginylglycylaspartic acid (RGD) with calcium phosphate grafts to enhance cell–biomaterial interactions have been controversial in the literature. Several works have demonstrated that RGD-functionalized hydroxyapatite (HA) surfaces improve cell adhesion, whereas others claim that RGD-loaded HA has an [...] Read more.
The strategies used to associate peptide arginylglycylaspartic acid (RGD) with calcium phosphate grafts to enhance cell–biomaterial interactions have been controversial in the literature. Several works have demonstrated that RGD-functionalized hydroxyapatite (HA) surfaces improve cell adhesion, whereas others claim that RGD-loaded HA has an inhibitory effect when serum is present in the biological medium. To investigate such contradictory results, we associated RGD with the HA surface using physical adsorption and chemical bonding methods and evaluated the cell adhesion and spreading in pre-osteoblasts culture with and without fetal bovine serum (FBS). The effect of functionalization methods on the physicochemical characteristics of both surfaces was analyzed using multiscale techniques. Adsorption assays of serum allowed us to estimate the impact of the association method on the HA surface’s reactivity. Physically adsorbed RGD did not increase the number of adhered cells due to the weak interactions between the peptide and the surface. Although chemical binding stabilizes RGD on the HA, the functionalization procedure covered the surface with molecules such as (3-aminopropyl)triethoxysilane (APTEs) and carbodiimide, changing the surface’s chemical activity. Serum protein adsorption decreased by 90%, revealing a significant reduction in the surface interactions with molecules of the biological medium. The present study’s findings showed that the RGD’s physical association with HA did not improve cell adhesion and that this phenomenon is highly dependent on the presence of serum proteins. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Dental and Biological Materials)
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11 pages, 1576 KiB  
Article
Opportunistic Pathogens Isolated from Peri-Implant and Periodontal Subgingival Plaque from Adjacent Teeth
by Ana Maísa Sá, José Manuel Mendes, António Sérgio Silva, Maria dos Prazeres Gonçalves, Mónica Cardoso and Cristina Coelho
Appl. Sci. 2023, 13(16), 9078; https://doi.org/10.3390/app13169078 - 9 Aug 2023
Cited by 2 | Viewed by 1628
Abstract
Even though most studies consider strict anaerobe Gram-negative bacteria as the main factor associated with peri-implantitis, other studies have identified other microorganisms present in implants related to peri-implant disease that have the ability to reduce the effectiveness of treatment, such as Candida spp., [...] Read more.
Even though most studies consider strict anaerobe Gram-negative bacteria as the main factor associated with peri-implantitis, other studies have identified other microorganisms present in implants related to peri-implant disease that have the ability to reduce the effectiveness of treatment, such as Candida spp., Enterococcus faecalis and Pseudomonas aeruginosa. Therefore, microbiologic diagnosis is important for the success of implant treatment. The main goal of this study was to detect Candida spp., E. faecalis and P. aeruginosa in the peri-implant and periodontal subgingival plaque in the presence or absence of disease and to relate the presence of these microorganisms with demographic data, hygiene habits, the type of implant connection and endodontic treatment. The study population consisted of 20 patients that filled out a questionnaire regarding gender, age, systemic diseases and oral hygiene. The peri-implant and periodontal subgingival plaque from an adjacent tooth, both with and without disease, were analysed for the presence of these three opportunistic pathogens. Microbiological analysis revealed a higher prevalence of E. faecalis in patients with and without periodontal and peri-implant disease. Candida spp. was identified in a higher degree in cases with disease, and P. aeruginosa was mostly detected in peri-implantitis. The detection of these three pathogens suggested a possible means of transmission of infection from adjacent teeth to implants, with the implant design associated with rehabilitation being a primary cause of pathogen growth. Although this study did not relate pathogen growth directly to periodontal disease, the high colony forming unit per millilitre (CFU/mL) values of E. faecalis may reveal an aetiological role of this bacterium in peri-implantitis. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Dental and Biological Materials)
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11 pages, 1337 KiB  
Article
In Vitro Investigation of the Mechanical Properties of Blended 3D-Printing Resins for Orthodontic Aligners: A Comparison between Commercial Resin and Nickel-Titanium Wire
by Piero Antonio Zecca, Salvatore Bocchieri, Marina Borgese, Carolina Dolci, Alessandra Campobasso, Giovanni Battista, Alberto Caprioglio and Mario Raspanti
Appl. Sci. 2023, 13(15), 9020; https://doi.org/10.3390/app13159020 - 7 Aug 2023
Cited by 1 | Viewed by 2012
Abstract
This scientific article investigates the mechanical properties of a novel three-dimensional-printing resin specifically designed for orthodontic aligners and compares it to other commonly used resins. The resin was made by blending two commercially available and certified resins to produce aligners with improved mechanical [...] Read more.
This scientific article investigates the mechanical properties of a novel three-dimensional-printing resin specifically designed for orthodontic aligners and compares it to other commonly used resins. The resin was made by blending two commercially available and certified resins to produce aligners with improved mechanical properties compared to each separate resin. The study examined the effect of the addition of NextDent Ortho Rigid resin on the mechanical properties of the specimens, more specifically analyzing the relationship between the amount of the added rigid resin and the mechanical properties of the specimens. The mechanical properties of the specimens and the nickel-titanium wires were analyzed using a three-point bending test setup. The results showed no statistically significant differences within the different groups of specimens. The study provides valuable insights into the potential of the resin to meet the mechanical demands of orthodontic treatments. It will contribute to the advancement of personalized orthodontic care through three-dimensional-printing technology. Blending commercially available and certified resins enables orthodontic practitioners to select the most suitable resin for each case, providing better outcomes for patients and increasing the efficiency of the treatment process. Further research and evaluation would be required to determine the suitability of the blended resin for orthodontic treatments. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Dental and Biological Materials)
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Review

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19 pages, 5294 KiB  
Review
Safety of 3D-Printed Acrylic Resins for Prosthodontic Appliances: A Comprehensive Cytotoxicity Review
by Guilherme Anziliero Arossi, Nauera Abou Abdou, Benjamin Hung, Isadora Martini Garcia, Roberto Zimmer and Mary Anne Melo
Appl. Sci. 2024, 14(18), 8322; https://doi.org/10.3390/app14188322 - 15 Sep 2024
Cited by 1 | Viewed by 2271
Abstract
Additive manufacturing resins used in dental prosthetics may retain uncured monomers post-polymerization, posing potential long-term patient exposure risks. Understanding the biological safety of these materials is crucial, particularly for 3D-printed acrylic-based prosthodontic devices such as occlusal nightguards, complete and partial dentures, and temporary [...] Read more.
Additive manufacturing resins used in dental prosthetics may retain uncured monomers post-polymerization, posing potential long-term patient exposure risks. Understanding the biological safety of these materials is crucial, particularly for 3D-printed acrylic-based prosthodontic devices such as occlusal nightguards, complete and partial dentures, and temporary fixed prostheses. This paper reviews the literature evaluating the cytotoxicity of such materials. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we conducted a scoping review using the MESH keywords related to population (P), intervention (I), comparison (C), and outcome (O) across databases, including OVID Medline, EMBASE, and SCOPUS. Our search, limited to peer-reviewed English language articles from 2015 to 2023, resulted in 22 papers. These studies, utilizing digital light processing (DLP) or stereolithography (SLA) printing methods, varied in examining different 3D-printed materials, as well as washing and post-curing protocols. The primary experimental cells used were human gingival fibroblasts (HGF) and mouse fibroblasts (L929). There are no statistical differences in biocompatibility regarding different commercially available resins, washing solutions, or methods. Improvements in cell viability were related to an increase in washing time, as well as post-curing time. After the polishing procedure, 3D resin-based printed occlusal devices perform similarly to milled and conventionally processed ones. Our findings underline the importance of appropriate washing and post-curing protocols in minimizing the cytotoxic risks associated with these 3D-printed resin-based devices. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Dental and Biological Materials)
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