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Optical Methods for Tissue Diagnostics, Volume II

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2619

Special Issue Editor


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Guest Editor
Faculty of Medicine, Department Medical Physics, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Interests: optical methods for tissue diagnostics; bio-molecular spectroscopy; x-ray diffraction; computational biophysics and drug design; molecular modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of non-ionizing radiation offers great promise as a non-invasive medical diagnosis tool. Despite the limited penetration depth in living tissue, optical methods are steadily bridging the gap between radiology and histopathology, due to their sensitivity to molecular, functional and structural content. This Special Issue attempts to cover novel works in tissue diagnostics using optical techniques. Contributions of both human studies and animal models are encouraged using either experimental approaches or analytical methods. The volume is open to innovative contributions involving aspects of the following topics:

  • Molecular spectroscopy and microspectroscopy;
  • Absorption, reflectance, emission and fluorescence spectroscopy;
  • Light–tissue interactions;
  • Optical clearing methods;
  • Nonlinear microscopy, including multiphoton excited fluorescence, harmonic generation and coherent anti-Stokes Raman scattering (CARS) microscopy;
  • 2D imaging, e.g., laser, speckle, intrinsic signals, calcium and voltage, molecular, hyperspectral, thermal-infrared imaging;
  • Functional near infrared spectroscopy (fNIRS) of the brain and other organs;
  • Tomographic imaging, such as optical coherence tomography, diffuse optical tomography and photoacoustic tomography.

Please feel free to read and download the published paper in Our Volume I Edition: https://www.mdpi.com/journal/applsci/special_issues/Optical_Methods_Tissue_Diagnostics.

Dr. Nikolaos Kourkoumelis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

9 pages, 694 KiB  
Article
The Effect of Different Optical Clearing Agents on the Attenuation Coefficient and Epidermal Thickness of Human Skin Assessed by Optical Coherence Tomography
by Maria Varaka, Martha Z. Vardaki, Georgios Gaitanis, Ioannis D. Bassukas and Nikolaos Kourkoumelis
Appl. Sci. 2022, 12(16), 8277; https://doi.org/10.3390/app12168277 - 19 Aug 2022
Cited by 6 | Viewed by 2166
Abstract
Background: Optical coherence tomography (OCT) is a non-invasive imaging technique based on the interferometry of backscattered light. However, strong light scattering hinders its applicability in clinical dermatology. The strength of scattering is exemplified by the attenuation coefficient which is the rate of [...] Read more.
Background: Optical coherence tomography (OCT) is a non-invasive imaging technique based on the interferometry of backscattered light. However, strong light scattering hinders its applicability in clinical dermatology. The strength of scattering is exemplified by the attenuation coefficient which is the rate of OCT signal decay in depth. Attenuation can be reduced by topical application of hyperosmotic liquids with a high refractive index, namely optical clearing agents (OCAs). In this study, we assessed the impact of different OCAs to enhance skin optical permeability in OCT images. In vivo tests were carried out to determine the OCT attenuation coefficient (μOCT) and epidermal thickness in the treated and untreated epidermis. Methods: Four OCAs were studied: Propylenglycol, propylenglycol combined with oleic acid in equal proportions (1:1 v/v), Vaseline, and liquid Vaseline. Percentage change of μOCT and epidermal thickness were estimated by OCT imaging of a healthy forearm skin, prior to the application of each OCA and after the application, at two time points, t1 = 5 min, and t2 = 90 min. μOCT was quantitatively obtained by fitting the OCT signal to a single scattering model. Results: The application of OCAs induced significant changes in both μOCT (decreased) and epidermal thickness (increased). The synergistic effect of the combined propylenglycol with oleic acid reduced the μOCT by 43% while propylenglycol induced the highest increase (33%) in epidermal thickness, both at t2. Conclusions: Topical administration of propylenglycol combined with oleic acid can reduce light attenuation in OCT imaging within the clinically relevant timeframe of 90 min. Full article
(This article belongs to the Special Issue Optical Methods for Tissue Diagnostics, Volume II)
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