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Translational Research in Dentistry: Latest Advancements and Prospects

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 804

Special Issue Editor


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Guest Editor
Department of Neuroscience, Reproductive Science and Dentistry, University of Naples Federico II, 80131 Naples, Italy
Interests: implantology; bioengineering; stem cells; hemocomponents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Translational research has emerged as a pillar of innovation in modern dentistry, effectively bridging the gap between laboratory discoveries and their application in clinical settings. This dynamic field integrates interdisciplinary knowledge from biomedical sciences, materials engineering, molecular biology, and clinical practice to accelerate the development of novel diagnostics, therapeutics, and regenerative strategies. As the demand for personalized and minimally invasive dental care grows, translational research plays a pivotal role in transforming promising scientific breakthroughs into viable solutions that enhance patient outcomes. Recent advances in stem cell therapies, biomimetic materials, digital dentistry, and microbiome research are reshaping the landscape of oral health care. Technologies such as 3D bioprinting, AI-driven diagnostics, and gene editing are no longer theoretical but are rapidly progressing toward clinical translation. This Special Issue invites high-quality contributions that highlight cutting-edge research, clinical trials, technological innovations, and future directions in translational dentistry. We aim to foster interdisciplinary dialogue and promote the dissemination of impactful studies that push the boundaries of dental science and practice. Join us in exploring how translational research continues to redefine the future of dentistry.

Dr. Roberta Gasparro
Guest Editor

Manuscript Submission Information

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Keywords

  • translational dentistry
  • dental innovation
  • regenerative dentistry
  • stem cell therapy
  • biomaterials
  • clinical applications
  • oral health research
  • precision dentistry

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Published Papers (1 paper)

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16 pages, 3781 KB  
Systematic Review
Augmented Reality in Dental Extractions: Narrative Review and an AR-Guided Impacted Mandibular Third-Molar Case
by Gerardo Pellegrino, Carlo Barausse, Subhi Tayeb, Elisabetta Vignudelli, Martina Casaburi, Stefano Stradiotti, Fabrizio Ferretti, Laura Cercenelli, Emanuela Marcelli and Pietro Felice
Appl. Sci. 2025, 15(17), 9723; https://doi.org/10.3390/app15179723 - 4 Sep 2025
Viewed by 636
Abstract
Background: Augmented-reality (AR) navigation is emerging as a means of turning pre-operative cone-beam CT data into intuitive, in situ guidance for difficult tooth removal, yet the scattered evidence has never been consolidated nor illustrated with a full clinical workflow. Aims: This [...] Read more.
Background: Augmented-reality (AR) navigation is emerging as a means of turning pre-operative cone-beam CT data into intuitive, in situ guidance for difficult tooth removal, yet the scattered evidence has never been consolidated nor illustrated with a full clinical workflow. Aims: This study aims to narratively synthesise AR applications limited to dental extractions and to illustrate a full AR-guided clinical workflow. Methods: We performed a PRISMA-informed narrative search (PubMed + Cochrane, January 2015–June 2025) focused exclusively on AR applications in dental extractions and found nine eligible studies. Results: These pilot reports—covering impacted third molars, supernumerary incisors, canines, and cyst-associated teeth—all used marker-less registration on natural dental surfaces and achieved mean target-registration errors below 1 mm with headset set-up times under three minutes; the only translational series (six molars) recorded a mean surgical duration of 21 ± 6 min and a System Usability Scale score of 79. To translate these findings into practice, we describe a case of AR-guided mandibular third-molar extraction. A QR-referenced 3D-printed splint, intra-oral scan, and CBCT were fused to create a colour-coded hologram rendered on a Magic Leap 2 headset. The procedure took 19 min and required only a conservative osteotomy and accurate odontotomy that ended without neurosensory disturbance (VAS pain 2/10 at one week). Conclusions: Collectively, the literature synthesis and clinical demonstration suggest that current AR platforms deliver sub-millimetre accuracy, minimal workflow overhead, and high user acceptance in high-risk extractions while highlighting the need for larger, controlled trials to prove tangible patient benefit. Full article
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