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The Recent Development of Functional Foods and Natural Products—Impacts on Human Health

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 2658

Special Issue Editors


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Guest Editor
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 17676 Kallithea, Greece
Interests: natural products; antioxidants; diabetes; human health

E-Mail
Guest Editor
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Kallithea, 17676 Athens, Greece
Interests: food chemistry; analysis; bioactive microconstituents; polyphenols; anthocyanins

Special Issue Information

Dear Colleagues,

Oxidative stress is the temporary or long-term increase in levels of reactive species, which disturb the cells’ metabolic and signaling pathways and lead to modifications of an organism’s macromolecules, which if not compensated, may result in cellular death. The body’s imbalance is now considered a major cause of aging and the development of chronic non-communicable diseases. The antioxidative substances in natural products can help protect the human system from diseases resulting from a weakened immune system.

Consumption of functional foods and natural products seems to affect human physiology and metabolism, exerting a significant impact on health. Due to their promising beneficial effects on human body functions beyond nutrient adequacy, functional foods, and natural products have gained increasing interest from the scientific community, consumers, and the food industry.

We are pleased to invite you to contribute a research/review paper to the the Special Issue entitled “The Recent Development of Functional Foods and Natural Products-Impact on Human Health” of the journal Applied Sciences. We are pleased to share that Applied Sciences received an updated Citescore of 5.3 for the year 2023. This Special Issue will be dedicated to new perspectives in chemical and functional properties of natural products.

Research areas may include (but are not limited to) the following:

  1. modern methods, technologies, and further handling of food prior to its consumption
  2. food components (nutrient and non-nutrient bioactives novel functional ingredients)
  3. studies investigating the effect of functional foods and natural products on beneficial effects on targeted body functions

We look forward to receiving your contributions.

Dr. Panagiotis T. Kanellos
Dr. Eirini A. Panagopoulou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • functional properties
  • human health
  • antioxidants
  • chronic diseases

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Published Papers (2 papers)

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Review

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21 pages, 1212 KB  
Review
Mushroom-Derived Compounds as Inhibitors of Advanced Glycation End-Products
by Filip Šupljika, Monika Kovačević and Mojca Čakić Semenčić
Appl. Sci. 2026, 16(2), 617; https://doi.org/10.3390/app16020617 - 7 Jan 2026
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Abstract
Mushrooms like Inonotus obliquus and Ganoderma lucidum show significant pharmacological promise. This review analyzes fungi as sources of natural inhibitors against Advanced Glycation End-products (AGEs)—key drivers of diabetes and neurodegeneration. We highlight that extracts from Lignosus rhinocerus and Auricularia auricula exhibit antiglycation potency [...] Read more.
Mushrooms like Inonotus obliquus and Ganoderma lucidum show significant pharmacological promise. This review analyzes fungi as sources of natural inhibitors against Advanced Glycation End-products (AGEs)—key drivers of diabetes and neurodegeneration. We highlight that extracts from Lignosus rhinocerus and Auricularia auricula exhibit antiglycation potency (IC50 as low as 0.001 mg/mL) superior to aminoguanidine. Inhibitory effects are attributed to bioactive fractions including FYGL proteoglycans, uronic acid-rich polysaccharides, and fungal-specific metabolites like ergothioneine. These compounds act through multi-target mechanisms across the glycation cascade: competitive inhibition of Schiff base formation, trapping reactive dicarbonyls (e.g., methylglyoxal), transition metal chelation, and direct scavenging of reactive oxygen species (ROS). Furthermore, the review addresses the transition from in vitro potency to in vivo efficacy (RAGE pathway modulation), stability during food processing (UV-B irradiation), and critical safety issues regarding heavy metal bioaccumulation. Mushroom-derived inhibitors represent a sustainable therapeutic alternative to synthetic agents, offering broader protection against glycative stress. This synthesis provides a foundation for developing standardized mushroom-based nutraceuticals for managing AGE-related chronic disorders. Full article
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21 pages, 388 KB  
Systematic Review
Caffeine, Dairy Products and Common Aspects of Dietary Intake Are Associated with Functional and Structural Alterations in Retinal Microcirculation: A Systematic Review
by Lazaros K. Yofoglu, Evaggelia K. Aissopou, Petros P. Sfikakis, Irini Chatziralli, Kalliopi Karatzi, Athanase D. Protogerou and Antonios A. Argyris
Appl. Sci. 2026, 16(3), 1172; https://doi.org/10.3390/app16031172 - 23 Jan 2026
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Abstract
Background: Caffeine, dairy products and other food items may influence retinal microcirculation. Retinal microvascular indices provide quantitative biomarkers of systemic microvascular health and are increasingly used in clinical and research settings. The aim of this study was to elucidate the possible effects of [...] Read more.
Background: Caffeine, dairy products and other food items may influence retinal microcirculation. Retinal microvascular indices provide quantitative biomarkers of systemic microvascular health and are increasingly used in clinical and research settings. The aim of this study was to elucidate the possible effects of these food products on structural and functional indices of the retinal microcirculation. Methods: Based on a registered protocol, we identified eligible interventional/observational studies examining the association of these factors with retinal biomarkers, including central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), arteriolar-to-venular diameter ratio (AVR), retinal vascular tortuosity, vessel diameter index (VDI) and retinal vessel flicker light-induced dilation (FID). Results: Fourteen studies were included addressing caffeine (4), dairy products (2) and other food (9) consumption. Acutely, caffeine intake was dose-dependently associated with narrowed CRAE, CRVE, decreased VDI and increased AVR and FID. Long-term, caffeine consumption was associated with larger CRVE and lower AVR, while decaffeinated coffee with larger CRAE and AVR and narrower CRVE. Low-fat dairy products, fish and fiber were associated with larger CRAE, smaller CRVE, and increased AVR, while red meat consumption was associated with narrower CRAE and lower AVR. Increased salt intake was associated with increased venular tortuosity, while almond consumption was associated with larger CRVE. Owing to substantial study heterogeneity, a meta-analysis was not feasible. Conclusions: Potentially clinically meaningful associations between food groups and retinal indices were identified. These associations should be considered when evaluating retinal microcirculation and assessing CVD risk since modification of these factors may be beneficial for the cardiovascular system. Full article
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