Antioxidants in the Prevention and Treatment of Diseases

Dear Colleagues, 

Reactive oxygen species (ROS) are highly unstable molecules, and they are able to interact easily with cellular structures, generating oxidative stress (OS). The influence of OS on various pathologies has been documented for decades; it is widely accepted that ROS are key signaling molecules that play a substantial role in various disorders. Over the past few decades, antioxidants of various sources have been widely used as possible remedies against OS, and studies have highlighted their significant therapeutic potency. Far from being just ROS scavengers, many of these complex biomolecules modulate various pathways involved in a wide range of pathologies, such as inflammation, cancer, metabolic disorders, cardiovascular diseases, and autoimmune diseases. Nowadays, synergistic treatments involving the use of antioxidants alongside classical treatments are commonly used; however, the research in the antioxidant area is far from over. Future studies elucidating the intricate influence of antioxidants on redox signaling pathways or investigating new antioxidant molecules or pharmaceutical forms with better bioavailability and long-term effects provide hope for the therapeutic treatment of many OS-related diseases. 

This Special Issue aims to publish a collection of original research papers and reviews focused on various antioxidant biomolecules which are potentially beneficial in oxidative stress-related pathologies. The volume is open to both experimental and clinical studies; papers are welcome to investigate the molecular interactions between antioxidant molecules and redox signaling pathways, or other relevant mechanisms. Studies investigating newly identified antioxidant molecules or focusing on novel pharmacological forms are also encouraged.

Dr. Bogdan Sevastre
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.