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Applied Sciences
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Bioactive Composite Materials: From Preparation to Application
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Bioactive Composite Materials: From Preparation to Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2117

Special Issue Editors

Prof. Dr. Bogdan Sevastre

E-Mail Website
Guest Editor
Pathophysiology Department, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 3-5 Manastur Street, 400372 Cluj-Napoca, Romania
Interests: phytotherapy; plant extracts; clinical pathology; physiopathology
Special Issues, Collections and Topics in MDPI journals
Dr. Alexandra Dreancă

E-Mail Website
Guest Editor
Department of Toxicology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania
Interests: pain management; pain assessment; complementary therapies; biomaterial applications; biomaterial science; acute toxicity tests; biomaterials tissue response; clinical toxicology; emergency toxicology

Special Issue Information

Dear Colleagues,

Tissue engineering via the use of composite biomaterials has become a subject of intensive research and has grown in significance in the field of regenerative medicine in recent years. The organs that are impacted determine which materials and synthesis techniques are used. For instance, polymers, glasses, ceramics, metals, carbon-based compounds, hydrogels and other materials are attractive materials for soft tissue and bone tissue engineering. Composites and hybrids are significant biomaterial types because they have a greater capacity for regeneration than their constituent parts. Currently, no specific guidelines have been established for addressing several tissue complications (large defects, lack of substance, comorbidities such as diabetes and osteoporosis, the necessity of auto or allographs, extensive burns, antioresistance), leading to limited treatment options; novel strategies are thus demanded to restore function and strength. To overcome these barriers, researchers have been developing diverse bioengineering methods in order to realize new and improved therapies for cutaneous and musculoskeletal disorders.

This domain is considered interdisciplinary, and novelty and successful applicability are essential to a new modern medical direction. This Special Issue welcomes papers that address the areas related to biomaterial composites.

Prof. Dr. Bogdan Sevastre
Dr. Alexandra Dreancă
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • composites
  • biomaterials
  • biocompatibility
  • nanomaterials
  • mecanobiology
  • nanoparticles

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Published Papers (2 papers)

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Research

17 pages, 1969 KiB  
Article
Topical Pentravan® Based Compositions with Naproxen and Its Proline Ester Derivative—A Comparative Study of Physical Properties and Permeation of Naproxen Through the Human Skin
by Ewelina Kopciuch, Paula Ossowicz-Rupniewska, Urszula Adamiak-Giera, Anna Nowak, Katarzyna Wilpiszewska, Monika Białecka, Łukasz Kucharski, Anna Muzykiewicz-Szymańska, Maciej Miernik, Mirosław Halczak, Maciej Romanowski and Ewa Janus
Appl. Sci. 2025, 15(3), 1338; https://doi.org/10.3390/app15031338 - 27 Jan 2025
Viewed by 526
Abstract
The compositions based on Pentravan® vehicle were prepared with (S)-naproxen, and its salt —(S)-naproxenate of L-prolinium isopropyl ester as active pharmaceutical ingredients, and two penetration enhancers from the group of sensates—menthol and Capsicum Tincture. Thermophysical properties of [...] Read more.
The compositions based on Pentravan® vehicle were prepared with (S)-naproxen, and its salt —(S)-naproxenate of L-prolinium isopropyl ester as active pharmaceutical ingredients, and two penetration enhancers from the group of sensates—menthol and Capsicum Tincture. Thermophysical properties of the mixtures of each naproxen form with enhancers were determined by DSC method. The stability of the prepared compositions after one- and three-month storage and the rheological properties were investigated. The permeation of active ingredients through the human skin was evaluated based on the in vitro study in Franz diffusion cells using the prepared compositions with each naproxen form. Increase in the permeability of the naproxen salt, especially in the presence of Capsicum Tincture, provides much faster and greater penetration of the skin by the drug. It seems to be promising the use of the developed composition in the form of pain relief and anti-inflammatory creams, occlusive compresses or topical patches. Moreover, the developed compositions can be crucial for the topical compositions made in compounding pharmacies by physicians’ recipes in individual pain pharmacotherapy. Full article
(This article belongs to the Special Issue Bioactive Composite Materials: From Preparation to Application)
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17 pages, 4433 KiB  
Article
Analysis of the Effect of Vegetable Broth Addition to a Gelatin Pork Edible Film and Coating Method on Select Physical Properties of Freeze-Dried Coated Vegetable Bars
by Agnieszka Ciurzyńska, Monika Janowicz, Magdalena Karwacka and Sabina Galus
Appl. Sci. 2024, 14(12), 5215; https://doi.org/10.3390/app14125215 - 15 Jun 2024
Viewed by 720
Abstract
The aim of this study was to analyze the selected physical properties of vegetable bars coated with a coating based on pork gelatin (8% or 12%) with (25% or 50%) or without vegetable broth. The scope of work included developing the composition of [...] Read more.
The aim of this study was to analyze the selected physical properties of vegetable bars coated with a coating based on pork gelatin (8% or 12%) with (25% or 50%) or without vegetable broth. The scope of work included developing the composition of edible coatings; preparing bars and coating freeze-dried vegetable bars; analyzing the water activity, dry matter content, the structure of vegetable bars based on microscopic analysis, and porosity; and then conducting a comparative analysis of the obtained results. The analyses show that the composition of the coating and the coating method influence the structure and selected physical properties of freeze-dried bars. Coating freeze-dried vegetable bars increases their water activity to the range of 0.215–0.389, and reduces their dry matter content to 93–96%. The porosity of the samples decreased (85–91%), but the use of coatings in the form of an edible film was more beneficial than immersing the dried material in a film-forming solution. The addition of vegetable broth to edible films improves the physical properties of the dried fruit and may additionally increase the taste of vegetable bars. Full article
(This article belongs to the Special Issue Bioactive Composite Materials: From Preparation to Application)
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