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Biomedical Applications of Bioactive Ingredients from Natural Products—2nd Edition

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 1115

Special Issue Editors


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Guest Editor
1. Pharmacoepidemiology Laboratory, Medical School, Democritus University of Thrace, Komotini, Greece
2. Department of Clinical, Pharmaceutical & Biological Sciences, University of Hertfordshire, Hatfield, UK
3. Department of Clinical Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: pharmacoepidemiology; neuropsychopharmacology; addiction medicine; psychoactive substances; ethnopharmacology; natural substances; herbal medicine
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Special Issue Information

Dear Colleagues,

Natural products have historically made a big contribution to the evolution of drug discovery, and bioactive ingredients and their structural analogues have a key role in preventing and treating non-communicable and chronic diseases—all of which has accelerated scientific interest in this field. Modern methods for the evaluation and manipulation of bioactive ingredients from natural products have enabled a better understanding of their mechanisms of action and a clearer view of their potential in medicinal applications.

In this Special Issue, we investigate closely the recent perspectives on the biomedical applications of bioactive ingredients and their structural analogues from natural products.

A particular focus of this Special Issue will be to summarize the recent technological developments that have enabled natural product-based drug discovery, highlight potential applications in the prevention and treatment of pathological conditions, discuss key challenges in identifying and establishing biological actions, and communicate the opportunities that stem from current research.

Dr. Georgia Eirini Deligiannidou
Dr. Christos Kontogiorgis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • pure compounds
  • encapsulation
  • antioxidant
  • anti-inflammatory
  • nanoparticles
  • bioactive compounds
  • in vitro
  • in vivo

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Published Papers (1 paper)

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Review

24 pages, 1193 KB  
Review
Exploring the Therapeutic Potential of Calendula and Chamomile in Dermatology: From Anti-Inflammatory and Antioxidant Properties to New Therapeutic Perspectives
by Luca Gammeri, Federica Li Pomi, Francesco Borgia, Eleonora Di Salvo, Antonino Nazareno Virga and Sebastiano Gangemi
Appl. Sci. 2026, 16(4), 1965; https://doi.org/10.3390/app16041965 - 16 Feb 2026
Viewed by 862
Abstract
Oxidative stress (OS) plays a central role in the pathogenesis of several cutaneous disorders, including inflammatory dermatoses, photoaging, and carcinogenesis. The imbalance between reactive oxygen species (ROS) production and endogenous antioxidant defenses contributes to inflammation, cellular senescence, and barrier dysfunction. Phytochemicals with antioxidant [...] Read more.
Oxidative stress (OS) plays a central role in the pathogenesis of several cutaneous disorders, including inflammatory dermatoses, photoaging, and carcinogenesis. The imbalance between reactive oxygen species (ROS) production and endogenous antioxidant defenses contributes to inflammation, cellular senescence, and barrier dysfunction. Phytochemicals with antioxidant and anti-inflammatory properties have therefore gained attention as potential therapeutic agents in dermatology. Calendula officinalis (CO) and Matricaria chamomilla (MC) contain bioactive compounds, including carotenoids, flavonoids, terpenoids, and phenolic acids, that modulate redox homeostasis and inflammatory pathways. Evidence from preclinical and clinical studies indicates that CO and MC exert photoprotective effects by reducing UV-induced ROS generation and preserving dermal collagen. Both extracts promote wound healing through fibroblast stimulation, collagen deposition, and antimicrobial activity. In chronic inflammatory dermatoses, including atopic dermatitis (AD) and psoriasis (Pso), CO and MC downregulate pro-inflammatory cytokines, thereby restoring immune balance. Emerging delivery systems have enhanced their skin bioavailability and clinical effectiveness. Collectively, current data support the antioxidant, anti-inflammatory, and regenerative properties of CO and MC, underscoring their potential in maintaining skin homeostasis and protecting against oxidative damage. Further standardized, large-scale clinical studies are warranted to validate their efficacy, safety, and optimal formulations for dermatological use. Full article
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