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Antioxidants
Special Issues
Advances in Oxidoreductases
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Advances in Oxidoreductases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 10 September 2026 | Viewed by 6596

Special Issue Editor

Dr. Byung Cheon Lee

E-Mail Website
Guest Editor
College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea
Interests: methionine oxidation; methionine restriction; aging; methionine sulfoxide reductase; redox biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidoreductases are enzymes that catalyze redox reactions, playing vital roles in metabolism, signaling, disease regulation, redox balance, tumor microenvironment modulation, and inflammation. Recent advancements in oxidoreductase research have greatly influenced fields like cancer therapy, immunology, and drug development, expanding our understanding of their involvement in cancer, inflammation, and metabolic disorders. Targeting specific oxidoreductases—such as MsrB1, TrxR, and NOX—holds promising potential for developing novel therapeutic strategies.

Despite our long-term study of oxidoreductases, they continue to reveal new functions and roles. Additionally, advancements in engineering technologies have facilitated their integration into innovative fields such as biosensors, expanding their research applications. This Special Issue aims to provide a platform for discussing and reviewing the latest research findings and developments in oxidoreductase-related studies.

We invite you to submit your latest research or a review article to this Special Issue, focusing on the function, regulation, and therapeutic potential of oxidoreductases, as well as their applications in fields such as redox biology, disease management, drug development, and biosensor technology.

Dr. Byung Cheon Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidoreductase
  • redox enzyme
  • metabolic regulation
  • signaling
  • cancer
  • immune regulation

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Published Papers (3 papers)

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Research

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14 pages, 5238 KB  
Article
Analysis of Catalase-Induced Activation of Intracellular Cell Signaling in Macrophages
by Kaiwen Mu, Ningjian Liang, Maidinai Sabier, Yu-Hsuan Liao and David. D. Kitts
Antioxidants 2026, 15(3), 366; https://doi.org/10.3390/antiox15030366 - 13 Mar 2026
Viewed by 648
Abstract
Hydrogen peroxide (H2O2) is a key extracellular redox signaling molecule that regulates diverse physiological processes, including immune cell activation and proliferation. However, its role in maintaining extracellular redox balance and mediating intercellular signaling remains underexplored. In this study, we [...] Read more.
Hydrogen peroxide (H2O2) is a key extracellular redox signaling molecule that regulates diverse physiological processes, including immune cell activation and proliferation. However, its role in maintaining extracellular redox balance and mediating intercellular signaling remains underexplored. In this study, we investigated how extracellular depletion of H2O2 by catalase modulates intracellular signaling pathways in macrophages. Catalase treatment effectively depleted extracellular H2O2 in a concentration- and time-dependent manner, leading to activation of mitogen-activated protein kinase (MAPK) pathways, including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38, as well as nuclear translocation of the nuclear factor κB (NF-κB) p65 subunit. Perturbation of extracellular redox status resulted in robust upregulation of inflammatory and oxidative stress–related genes, including cyclooxygenase-2 (COX-2), C-C motif chemokine ligand 5 (CCL5), inducible nitric oxide synthase (iNOS), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. This transcriptional response was accompanied by increased nitric oxide (NO) production and enhanced nuclear translocation and DNA-binding activity of nuclear factor erythroid 2–related factor 2 (Nrf2). Mechanistically, our data suggest that NO-mediated S-nitrosylation contributes to activation of the cellular antioxidant response. In addition, catalase-mediated depletion of extracellular H2O2 significantly (p < 0.05) suppressed 5-bromo-2′-deoxyuridine (BrdU) incorporation, indicating inhibition of macrophage proliferation. Together, these findings demonstrate that extracellular H2O2 functions as a physiological redox signal that maintains cellular homeostasis, and that its removal triggers a coordinated intracellular response involving both inflammatory activation and antioxidant defense. This study highlights the critical role of extracellular redox balance in shaping macrophage function and provides mechanistic insight into how changes in the oxidative environment regulate downstream immune signaling pathways. Full article
(This article belongs to the Special Issue Advances in Oxidoreductases)
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14 pages, 1787 KB  
Article
Biosacetalin (1,1-Diethoxyethane) Improves Healthy Lifespan in C. elegans and Rats
by Vu Hoang Trinh, Geun-Haeng Lee, Eun-Jong Kim, Jooyeon Sohn, Jin-Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Sang-Chul Park, Min-Keun Song and Seung-Rock Lee
Antioxidants 2026, 15(2), 160; https://doi.org/10.3390/antiox15020160 - 24 Jan 2026
Cited by 2 | Viewed by 1317
Abstract
Recent evidence has highlighted the pivotal roles of reactive oxygen species (ROS) and the SIRT1, AMPK, and mTOR signaling pathways in aging and longevity, making them attractive targets for studies of lifespan-extending interventions. We previously demonstrated that 1,1-diethoxyethane (1,1-DEE) could interact with mitochondrial [...] Read more.
Recent evidence has highlighted the pivotal roles of reactive oxygen species (ROS) and the SIRT1, AMPK, and mTOR signaling pathways in aging and longevity, making them attractive targets for studies of lifespan-extending interventions. We previously demonstrated that 1,1-diethoxyethane (1,1-DEE) could interact with mitochondrial complex I (NADH–ubiquinone oxidoreductase), leading to transient mitochondrial ROS (mtROS) production and activation of the AMPK pathway. This study further examined the effects of 1,1-DEE on longevity in model organisms. Treatment with 1,1-DEE decreased senescence in endothelial cell EA.hy926. In Caenorhabditis elegans (C. elegans), 1,1-DEE induced a hormetic response and extended the lifespan, whereas its structural isoform, 1,2-diethoxyethane (1,2-DEE), showed no such effect. In rat models, administration of 1,1-DEE markedly improved survival rate, mortality risk, restricted mean survival time (RMST), and median lifespan, associated with an accelerated body weight reduction. Additionally, 1,1-DEE could also enhance learning and memory, as assessed by the Morris water maze test in rats. These findings suggest that 1,1-DEE may serve as a novel small-molecule modulator of mitochondrial function and redox signaling, with potentials for promoting anti-aging and longevity. Full article
(This article belongs to the Special Issue Advances in Oxidoreductases)
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Review

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20 pages, 3618 KB  
Review
Superoxide Dismutases in Immune Regulation and Infectious Diseases
by Tong Liu, Jiajin Shang and Qijun Chen
Antioxidants 2025, 14(7), 809; https://doi.org/10.3390/antiox14070809 - 30 Jun 2025
Cited by 10 | Viewed by 3892
Abstract
Superoxide dismutases (SODs) maintain redox homeostasis through the catalytic dismutation of superoxide anions, thereby affording protection to organisms against oxidative damage. The SOD family, encompassing Cu/Zn-SOD, Mn-SOD, Fe-SOD, and Ni-SOD, exhibits structural diversity and constitutes a multilevel antioxidant defense system with discrete subcellular [...] Read more.
Superoxide dismutases (SODs) maintain redox homeostasis through the catalytic dismutation of superoxide anions, thereby affording protection to organisms against oxidative damage. The SOD family, encompassing Cu/Zn-SOD, Mn-SOD, Fe-SOD, and Ni-SOD, exhibits structural diversity and constitutes a multilevel antioxidant defense system with discrete subcellular localizations. Beyond their antioxidant functions, SODs also function as immunomodulatory proteins, regulating the maturation, proliferation, and differentiation of immune cells. They further fulfill a crucial role in host responses to parasitic infections. The current review synthesizes and critically evaluates extant research to comprehensively delineate the molecular architecture of SODs, their intricate post-translational modification (PTM) networks, and their dual regulatory mechanisms at the interface of immunomodulation and pathological processes. This review establishes a critical framework for elucidating the biological significance of redox homeostasis maintenance. Full article
(This article belongs to the Special Issue Advances in Oxidoreductases)
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