Bacterial Infections, Oxidative Stress, and Inflammation: Integrative Therapeutic Solutions

Dear Colleagues,

Bacterial infections remain a significant global health challenge, contributing to high morbidity and mortality rates. The interplay between bacterial pathogens and the host immune system often results in a cascade of molecular events characterized by oxidative stress and inflammation. These interconnected processes play critical roles in the progression of infectious diseases, influencing both acute and chronic outcomes.

Oxidative stress, driven by an imbalance between reactive oxygen species (ROS) and the antioxidant defense system, is a hallmark of bacterial infections. Excessive ROS production can damage cellular components, including lipids, proteins, and DNA, exacerbating tissue damage and promoting inflammatory pathways. In parallel, the host’s inflammatory response, while essential for controlling bacterial proliferation, can become dysregulated, leading to chronic inflammation and tissue injury.

This Special Issue aims to explore the intricate relationship between bacterial infections, oxidative stress, and inflammation. We welcome original research articles, reviews, and case studies that focus on but are not limited to the following topics:

• The molecular mechanisms of oxidative stress and inflammation during bacterial infections;
• The role of bacterial virulence factors in modulating host oxidative and inflammatory responses;
• Novel biomarkers for oxidative stress and inflammation in bacterial infections;
• Antioxidant and anti-inflammatory therapeutic strategies to mitigate bacterial infection-induced damage;
• Interactions between the microbiota, oxidative stress, and inflammation in health and disease;
• Cutting-edge techniques for studying oxidative stress and inflammation in the context of bacterial infections.

This Special Issue aims to provide a comprehensive overview of the mechanisms and clinical implications of oxidative stress and inflammation in bacterial infections. It also aims to advance understanding in this field and present therapeutic strategies to combat bacterial infections and their associated oxidative and inflammatory pathologies. We welcome contributions from diverse disciplines, including microbiology, immunology, pharmacology, and clinical medicine, to foster interdisciplinary dialog and collaboration.

We look forward to receiving your valuable contributions.

Dr. Hicham Wahnou
Dr. Gustavo Fehrenbach
Dr. Tielidy Lima
Guest Editors

Manuscript Submission Information

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