Regulation of Autophagy by Natural Compounds and Their Antioxidant Activity

Dear Colleagues,

A relatively unexplored field of study is the role of fundamental biological processes such as autophagy as a cellular response to a redox imbalance and the role of natural compounds in modulating this response in physiological (aging) and pathological contexts (cancer, cardiovascular and neurodegenerative diseases).

The interplay between reactive oxygen species (ROS) and natural compounds as autophagy modulators is the focus of different studies based on different cellular models (such as cancer vs. normal cells). Furthermore, although connections between ROS and autophagy are observed under various pathological conditions, the mode of activation of autophagy and the potential protective or cytotoxic functions are not fully understood.

Notably, recent advances in the field of redox regulation of autophagy focus on the role of natural compounds as activators of antioxidant response regulated by the transcription factor NFR2/Keap1 system.

This Special Issue focuses on studies that could “connect the dots” between the effects of natural compounds as inducers of autophagy and ROS imbalance in different cellular contexts to better understand the roles of autophagy in several chronic degenerative diseases and aging and utilize it as a therapeutic target.

Dr. Maria Russo
Prof. Dr. Immacolata Castellano
Dr. Gian Luigi Russo
Guest Editors

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