Redox Metabolism of Gaseous Signaling Molecules in Illness
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 369
Special Issue Editor
Interests: nitric oxide; hydrogen sulfide; persulfide/polysulfide; sulfur metabolism; redox reaction; interaction/crosstalk; antioxidants; disease; therapy; detection methods
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since the function of nitric oxide (NO) emerged, the biological role of a number of gaseous signaling molecules has been investigated. Translational studies have demonstrated the therapeutic/preventive capacity of gaseous signaling molecules against illness. Gaseous signaling molecules such as nitric oxide and sulfide can be converted into their metabolites, which possess biological activity and physiological/pathophysiological roles. For example, the metabolites of NO include nitrite, nitrate, HSNO, and RSNO. Hydrogen sulfide (H2S) can be oxidized to generate persulfide, polysulfide, thiosulfate, or other reactive sulfur species. Studies have demonstrated therapeutic strategies exploiting these metabolite molecules in illness. However, it is extremely challenging to discriminate between the role of gaseous signaling molecules themselves and the role of their metabolites. The role of the enzymes responsible for redox metabolism in illness also remains unclear. Intensive studies are required to help understand the precise role of gaseous signaling molecules, metabolites, and the regulation of redox metabolism in order to establish more clinically relevant therapies involving these molecules.
This Special Issue of Antioxidants aims to bring together original research articles, perspectives, and review articles related to the role of gaseous signaling molecules, metabolites, and the regulation of redox metabolism in illness.
Dr. Eizo Marutani
Guest Editor
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Keywords
- Gaseous signaling molecules and metabolites
- Nitric oxide metabolism
- Sulfide metabolism
- Reactive sulfur species
- Antioxidative stress
- Health and illness
- Translational research
- Redox signaling
- Crosstalk
