Nitric Oxide (NO) and Hydrogen Sulfide (H2S) in Biology, Illness, and Therapies—3rd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 29
Special Issue Editor
Interests: nitric oxide; hydrogen sulfide; persulfide/polysulfide; sulfur metabolism; redox reaction; interaction/crosstalk; antioxidants; disease; therapy; detection methods
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gaseous signaling molecules, including nitric oxide (NO), carbon dioxide (CO), and hydrogen sulfide (H2S), have emerged as physiologically and pathophysiologically important mediators in mammals. Manipulating these mediators as a therapeutic measure appears promising in various diseases, and the inhalation of NO has, at least partly, enhanced their clinical application. The manipulation of H2S or persulfide/polysulfide, which are oxidative products of H2S, is being explored in clinical trials. However, these therapies still face challenges regarding broader clinical applications due to their toxicity, rapid diffusion, short half-life, and narrow therapeutic window. Innovative methods or strategies are required to enable more successful clinical applications for these gaseous mediators. These mediators or their metabolites also crosstalk/interact with each other and have the potential to undergo nonspecific diverse reactions, which complicate our understanding of gaseous mediator biology; this remains to be elucidated in future studies.
In this Special Issue, we welcome the submission of original research articles or review articles that focus on physiology/pathophysiology, therapies, detection methods, and redox reactions related to NO, H2S, and their metabolites, facilitating the establishment of novel therapies to overcome illnesses.
Dr. Eizo Marutani
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- nitric oxide
- hydrogen sulfide
- persulfide/polysulfide
- sulfur metabolism
- redox reaction
- interaction/crosstalk
- antioxidants
- disease
- therapy
- detection methods
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