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Antioxidants
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Oxidative Stress and Dietary Health: The Role of Functional Foods...
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Oxidative Stress and Dietary Health: The Role of Functional Foods and Nutritional Supplements

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 5081

Special Issue Editor

Dr. Ivana Jukić

E-Mail Website
Guest Editor
Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia
Interests: vascular physiology; microcirculation; endothelial function; nutrition; cardiovascular physiology; oxidative stress

Special Issue Information

Dear Colleagues,

Proper nutrition plays a pivotal role in both health and developmental processes. Healthy nutrition is associated with the better health of infants, children and mothers, safer pregnancies and births, stronger immune system activity and lower probability of non-communicable chronic diseases (including diabetes and CV diseases). The global use of dietary supplements has increased. While their primary aim is to provide essential nutrients such as vitamins and minerals to maintain health, there has been a growing interest in functional ingredients in foods in recent decades. These ingredients not only provide nutrients and energy, but also offer beneficial effects for human health, enhancing specific physiological responses and potentially reducing the risk of disease. The health benefits of nutritional supplements and functional foods are observed across different age groups and many different areas of human physiology such as the cardiovascular system, cognition and neurodegenerative diseases, gastrointestinal health and cancer prevention. Oxidative stress is linked to the pathogenesis of several chronic diseases. Nutrition serves as a crucial regulator of oxidative stress in the human body, and the dietary consumption of nutrients possessing antioxidant properties can benefit human health by limiting oxidative damage.

In this Special Issue, we invite researchers to provide original research articles, clinical reports and review articles centered on the interplay between oxidative stress and nutrition. With the aim of providing a comprehensive overview of this topic, papers from a wide range of scientific fields, such as physiology, medicine and nutrition, are particularly encouraged.

Dr. Ivana Jukić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional food
  • diet
  • dietary supplements
  • nutrition
  • oxidative stress

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Published Papers (4 papers)

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Research

26 pages, 14636 KiB  
Article
Hepatoprotective Effects of Citri reticulatae Pericarpium and Chaenomelese speciosa (Sweet) Nakai Extracts in Alcohol-Related Liver Injury: Modulation of Oxidative Stress, Lipid Metabolism, and Gut Microbiota
by Shuangshuang Ma, Lingtao Kang, Zhipeng Gao, Zhaoping Pan, Lvhong Huang, Jiaxu Chen, Yanfang Liao, Jiajing Guo and Fuhua Fu
Antioxidants 2025, 14(3), 343; https://doi.org/10.3390/antiox14030343 - 14 Mar 2025
Viewed by 597
Abstract
Chronic and excessive alcohol consumption induces alcohol-related liver injury (ALI), characterized by oxidative stress (OS), disrupted lipid metabolism, and gut microbiota dysbiosis. Given the lack of effective pharmacological treatments, flavonoid-rich fruits have attracted growing attention as potential intervention strategies. This study investigated the [...] Read more.
Chronic and excessive alcohol consumption induces alcohol-related liver injury (ALI), characterized by oxidative stress (OS), disrupted lipid metabolism, and gut microbiota dysbiosis. Given the lack of effective pharmacological treatments, flavonoid-rich fruits have attracted growing attention as potential intervention strategies. This study investigated the independent and combined effects of extracts from Citri reticulatae pericarpium (CRPE) and Chaenomeles speciosa (Sweet) Nakai (CSPE), previously shown to possess hepatoprotective properties, in a mouse model of ethanol-induced chronic ALI. The flavonoid composition of CRPE and CSPE was characterized using LC-MS/MS, and their potential mechanisms of action were further elucidated through transcriptomic analysis. The results showed that CRPE and CSPE, whether administered individually or in combination, effectively alleviated alcohol-induced hepatic histological damage and inflammatory responses. Furthermore, both extracts significantly reduced OS and improved lipid metabolism. Notably, CRPE, CSPE, and their combination regulated the gut microbiota, as shown by increased abundances of beneficial bacteria such as Lactobacillus and Bifidobacterium, along with elevated levels of short-chain fatty acids (SCFAs). These findings highlight that combinations of multiple fruit extracts exhibit significant potential in alleviating ALI by modulating the gut microbiota, providing valuable insights for the development of functional foods. Full article
(This article belongs to the Special Issue Oxidative Stress and Dietary Health: The Role of Functional Foods and Nutritional Supplements)
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19 pages, 2844 KiB  
Article
Effect of n-3 Polyunsaturated Fatty Acids Enriched Chicken Meat Consumption in Relation to Oxidative Stress Marker Levels in Young Healthy Individuals: A Randomized Double-Blind Study
by Tihana Nađ, Nikolina Kolobarić, Zrinka Mihaljević, Ines Drenjančević, Petar Šušnjara, Ana Stupin, Darjan Kardum, Zlata Kralik, Gordana Kralik, Manuela Košević and Ivana Jukić
Antioxidants 2025, 14(2), 204; https://doi.org/10.3390/antiox14020204 - 11 Feb 2025
Viewed by 928
Abstract
Oxidative stress and inflammation are considered important risk contributors for various diseases. Over the last few decades, increasing attention has been focused on the role of n-3 polyunsaturated fatty acids (n-3 PUFAs) in human health and disease. We aimed to evaluate the effect [...] Read more.
Oxidative stress and inflammation are considered important risk contributors for various diseases. Over the last few decades, increasing attention has been focused on the role of n-3 polyunsaturated fatty acids (n-3 PUFAs) in human health and disease. We aimed to evaluate the effect of n-3 PUFA-enriched chicken meat consumption (~1500 mg of n-3 PUFAs intake per day) for three weeks on oxidative status and antioxidative capacity in young healthy individuals. This was a randomized, double-blinded, controlled trial, in which thirty-nine young healthy people were randomly allocated to eating 500 g/day of regular chicken meat (Control group) or n-3 PUFA-enriched chicken meat (n-3 PUFAs group) over 3 weeks. Subjects’ biochemical parameters, including serum lipids level, liver enzymes, serum activities of antioxidant enzymes (glutathione peroxidase (GPx), superoxide dismutase (SOD)), serum oxidative stress markers (thiobarbituric acid reactive substances (TBARS) and ferric-reducing ability (FRAP)), as well as intracellular production of reactive oxygen species (ROS) in peripheral blood mononuclear cells, were assessed before and after completing the three-week dietary protocol. N-3-enriched chicken meat consumption significantly reduced high-sensitivity C reactive protein (hsCRP) serum level and increased the level of the antioxidant defense marker, FRAP. Furthermore, GPx and SOD enzyme activities significantly increased in the n-3 PUFAs group compared to baseline, which was accompanied by significantly decreased ROS production. In healthy young individuals, the 3-week dietary intake of n-3 PUFA-enriched chicken meat significantly increased the serum total antioxidant and anti-inflammatory potential, indicating that n-3 PUFAs may be protective in resting health condition without inflammatory processes. Full article
(This article belongs to the Special Issue Oxidative Stress and Dietary Health: The Role of Functional Foods and Nutritional Supplements)
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19 pages, 3331 KiB  
Article
Spermidine Enhances Mitochondrial Bioenergetics in Young and Aged Human-Induced Pluripotent Stem Cell-Derived Neurons
by Leonora Szabo, Imane Lejri, Amandine Grimm and Anne Eckert
Antioxidants 2024, 13(12), 1482; https://doi.org/10.3390/antiox13121482 - 4 Dec 2024
Cited by 1 | Viewed by 1705
Abstract
The accumulation of damaged mitochondria has long been considered a hallmark of the aging process. Among various factors, age-related mitochondrial alterations comprise bioenergetic impairments and disturbances in reactive oxygen species (ROS) control, thereby negatively affecting mitochondrial performance and ultimately accelerating aging. Previous studies [...] Read more.
The accumulation of damaged mitochondria has long been considered a hallmark of the aging process. Among various factors, age-related mitochondrial alterations comprise bioenergetic impairments and disturbances in reactive oxygen species (ROS) control, thereby negatively affecting mitochondrial performance and ultimately accelerating aging. Previous studies have revealed that polyamine spermidine appears to exert health-protective and lifespan-promoting effects. Notably, recent findings have also described a spermidine-induced improvement in age-associated mitochondrial dysfunction, but the beneficial effects of spermidine on aged mitochondria have not been entirely examined yet. Here, we show that spermidine positively regulates several parameters related to mitochondrial bioenergetics and mitochondrial redox homeostasis in young and aged human-induced pluripotent stem cell-derived neurons. We report that spermidine treatment increases adenosine triphosphate production and mitochondrial membrane potential, which is accompanied by an attenuation in mitochondrial ROS levels in both age groups. Furthermore, we demonstrate a spermidine-mediated amelioration in mitochondrial respiration in both young and aged neurons. Overall, our findings suggest that nutritional spermidine supplementation might represent an attractive therapeutic approach to enhance mitochondrial function, consequently decelerating aging. Full article
(This article belongs to the Special Issue Oxidative Stress and Dietary Health: The Role of Functional Foods and Nutritional Supplements)
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23 pages, 2646 KiB  
Article
Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model
by Danila Di Majo, Nicolò Ricciardi, Alessandra Moncada, Mario Allegra, Monica Frinchi, Valentina Di Liberto, Rosa Pitonzo, Francesca Rappa, Filippo Saiano, Filippo Vetrano, Alessandro Miceli, Giuseppe Giglia, Giuseppe Ferraro, Pierangelo Sardo and Giuditta Gambino
Antioxidants 2024, 13(11), 1324; https://doi.org/10.3390/antiox13111324 - 30 Oct 2024
Viewed by 1028
Abstract
Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT’s antioxidant properties and its positive effects on metabolic syndrome (MetS), a condition characterized by obesity, [...] Read more.
Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT’s antioxidant properties and its positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, and oxidative stress. This study investigates for the first time a derivative from GT, i.e., the juice (GTJ), which could be a potential candidate for development as a functional food. We first characterized GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, a known peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, using High-Performance Liquid Chromatography (HPLC)–mass spectrometry. Then, using a high-fat-diet (HFD) rat model, we assessed the impact of daily GT juice supplementation in addressing MetS. We outlined that GTJ improved body weight and leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic oxidative stress, and steatosis in HFD rats. Furthermore, GT juice enhances the hepatic transcription of PPAR-α, thus putatively promoting fatty acid oxidation and lipid metabolism. These findings suggest that GT juice mitigates lipidic accumulation and putatively halters oxidative species at the hepatic level through PPAR-α activation. Our study underscores the protective effects of GT juice against MetS, highlighting its future potential as a nutraceutical for improving dysmetabolism and associated alterations. Full article
(This article belongs to the Special Issue Oxidative Stress and Dietary Health: The Role of Functional Foods and Nutritional Supplements)
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