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Natural Products Targeting on Oxidative Stress-Related Diseases II

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A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 10969

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Special Issue Editors

Prof. Dr. Wei Chen

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Guest Editor

Institute of Food Bioscience and Technology, Zhejiang University, Hangzhou 310058, China
Interests: antioxidants; obesity; diabetes; cancer; oxidative stress; autophagy; cell signaling
Special Issues, Collections and Topics in MDPI journals

Dr. Hongming Su

E-Mail Website
Co-Guest Editor

Department of Food Science and Nutrition, University of Minnesota, Minneapolis, MN 55455, USA
Interests: nutritional biochemistry; adipocyte biology; metabolic diseases; antioxidants; lipid droplet; natural products; food nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress plays a role in various chronic diseases, including atherosclerosis, neurodegenerative diseases, obesity, diabetes, chronic obstructive pulmonary disease (COPD) and cancer. However, the underlying molecular mechanisms by which oxidative stress contributes to the progression and pathogenesis of chronic diseases remain largely unknown. Emerging evidence indicates that reactive oxygen species (ROSs), major molecular regulators of redox signalling and function, play diverse roles in mediating and maintaining physiological homeostasis in response to external or internal stresses. Therefore, elucidating the physiological and biological roles of oxidative stress in chronic diseases and antioxidant defences induced by natural products through scavenging ROSs would expand our understanding of redox signalling, dietary components and pharmaceutical intervention of oxidative stress.

Over the last few decades, extensive studies have showed that natural products provide antioxidant defences against several chronic diseases, both in preclinical and clinical studies, with less side effects and more efficacy compared to many traditional non-natural, synthetic drugs. Natural products with an antioxidant capacity were reported to actively restore the redox imbalance associated with chronic diseases through regulating redox signalling and function. However, a large number of natural products are still unexploited, and their underlying molecular mechanisms deserve further investigation. A better understanding of the antioxidant action of natural products would pave the way for novel oxidative-stress-targeting drug development.

We are inviting you to submit your latest research findings or a review article to this Special Issue, which will provide the latest information on the beneficial effects of natural antioxidants and demonstrate the underlying molecular mechanisms of their bioactivities using various in vitro and in vivo disease models. Potential topics include: new techniques for extraction and purification of natural functional ingredients and their application to prevent food and environmental toxin-induced oxidative stress; and health-promoting benefits of natural products for chronic diseases, including diabetes, obesity, fatty liver, cardiovascular disease, neurodegenerative diseases, aging, cancer and oxidative-stress-related diseases.

Prof. Dr. Wei Chen
Dr. Hongming Su
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

natural products
oxidative stress
ROS
redox signalling
diabetes
obesity
inflammation
cardiovascular diseases
cancer
neurodegenerative diseases
aging
fatty liver

Published Papers (4 papers)

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Research

13 pages, 3745 KiB

Open AccessArticle

Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson’s Disease Models by Alleviating Oxidative Stress

by Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu and Chengwu Zhang

Antioxidants 2023, 12(1), 153; https://doi.org/10.3390/antiox12010153 - 09 Jan 2023

Cited by 4 | Viewed by 2793

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. Increasing evidence suggests that oxidative stress is the key causative factor of PD. Due to their capacity to alleviate oxidative stress, antioxidants hold great potential for the treatment of PD. Vitamins are essential organic substances for maintaining the life of organisms. Vitamin deficiency is implicated in the pathogenesis of various diseases, such as PD. In the present study, we investigated whether administration of vitamin B12 (VB12) could ameliorate PD phenotypes in vitro and in vivo. Our results showed that VB12 significantly reduced the generation of reactive oxygen species (ROS) in the rotenone-induced SH-SY5Y cellular PD model. In a Parkin gene knockout C. elegans PD model, VB12 mitigated motor dysfunction. Moreover, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse PD model, VB12 also displayed protective effects, including the rescue of mitochondrial function, dopaminergic neuron loss, and movement disorder. In summary, our results suggest that vitamin supplementation may be a novel method for the intervention of PD, which is safer and more feasible than chemical drug treatment. Full article

(This article belongs to the Special Issue Natural Products Targeting on Oxidative Stress-Related Diseases II)

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19 pages, 7569 KiB

Open AccessArticle

Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation

by Honghong Zhan, Qingxiu Pu, Xiaoliang Long, Wei Lu, Guowei Wang, Fancheng Meng, Zhihua Liao, Xiaozhong Lan and Min Chen

Antioxidants 2022, 11(12), 2307; https://doi.org/10.3390/antiox11122307 - 22 Nov 2022

Cited by 1 | Viewed by 1483

Abstract

Acute kidney injury (AKI) is described as the abrupt decrease in kidney function always accompanied by inflammation. The roots of Oxybaphus himalaicus Edgew. have long been used in Tibetan folk medicine for the treatment of nephritis. Nevertheless, modern pharmacological studies, especially about the underlying mechanism of O. himalaicus medications, are still lacking. Here, in lipopolysaccharide (LPS)-induced RAW264.7 macrophages, the O. himalaicus extract (OE) showed significant anti-inflammatory activity with the dose dependently reducing the LPS-stimulated release of nitric oxide and the mRNA level and protein expression of inflammatory cytokines and reversed the activation of nuclear factor kappa B (NF-κB). Co-immunoprecipitation assay indicated that OE inhibited Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2) complex formation and further suppressed both myeloid differentiation factor 88 (MyD88)-dependent and TIR-domain-containing adapter-inducing interferon-β (TRIF)-dependent cascades activation. In addition, OE could restrain NADPH oxidase 2 (NOX2) endocytosis by blocking TLR4/MD2 complex formation to prevent reactive oxygen species production. In LPS-induced AKI mice, OE treatment mitigated renal injury and inflammatory infiltration by inhibiting TLR4/MD2 complex formation. UPLC-MS/MS analysis tentatively identified 41 components in OE. Our results indicated that OE presented significant anti-inflammatory activity by inhibiting TLR4/MD2 complex formation, which alleviated LPS-induced AKI in mice. Full article

(This article belongs to the Special Issue Natural Products Targeting on Oxidative Stress-Related Diseases II)

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16 pages, 3514 KiB

Open AccessArticle

Caesalpinia sappan Linn. Ameliorates Allergic Nasal Inflammation by Upregulating the Keap1/Nrf2/HO-1 Pathway in an Allergic Rhinitis Mouse Model and Nasal Epithelial Cells

by Bo-Jeong Pyun, Kyuhyung Jo, Joo Young Lee, Ami Lee, Myung-A Jung, Youn-Hwan Hwang, Dong Ho Jung, Kon-Young Ji, Susanna Choi, Yun Hee Kim and Taesoo Kim

Antioxidants 2022, 11(11), 2256; https://doi.org/10.3390/antiox11112256 - 15 Nov 2022

Cited by 3 | Viewed by 2465

Abstract

Allergic rhinitis (AR) is a common upper-airway inflammatory disease of the nasal mucosa caused by immunoglobulin (IgE)-mediated inflammation. AR causes various painful clinical symptoms of the nasal mucosa that worsen the quality of daily life, necessitating the urgent development of therapeutic agents. Herein, we investigated the effects of Caesalpinia sappan Linn. heartwood water extract (CSLW), which has anti-inflammatory and antioxidant properties, on AR-related inflammatory responses. We examined the anti-inflammatory and anti-allergic effects of CSLW in ovalbumin (OVA)-induced AR mice and in primary human nasal epithelial cells (HNEpCs). Administration of CSLW mitigated allergic nasal symptoms in AR mice, decreased total immune cell and eosinophil counts in nasal lavage fluid, and significantly reduced serum levels of OVA-specific IgE, histamine, and Th2 inflammation-related cytokines. CSLW also inhibited the infiltration of several inflammatory and goblet cells, thereby ameliorating OVA-induced thickening of the nasal mucosa tissue. We found that CSLW treatment significantly reduced infiltration of eosinophils and production of periostin, MUC5AC, and intracellular reactive oxygen species through the Keap1/Nrf2/HO-1 pathway in HNEpCs. Thus, our findings strongly indicate that CSLW is a potent therapeutic agent for AR and can improve the daily life of patients by controlling the allergic inflammatory reaction of the nasal epithelium. Full article

(This article belongs to the Special Issue Natural Products Targeting on Oxidative Stress-Related Diseases II)

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Graphical abstract

17 pages, 2806 KiB

Open AccessArticle

Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

by Jianling Mo, Jingdan Ni, Ming Zhang, Yang Xu, Yuting Li, Naymul Karim and Wei Chen

Antioxidants 2022, 11(9), 1674; https://doi.org/10.3390/antiox11091674 - 27 Aug 2022

Cited by 29 | Viewed by 3546

Abstract

Mulberry has attracted wide attention due to its substantial nutritional values. This work first studied the protective effect of mulberry anthocyanins (MAS) on dextran sulfate sodium (DSS)-induced colitis. The mice experiment was designed as four groups including normal mice (Control), dextran sodium sulfate (DSS)-fed mice, and DSS plus 100 mg/kg·bw MAS-fed mice (LMAS-DSS) or DSS plus 200 mg/kg·bw MAS-fed mice (HMAS-DSS). Mice were given MAS by gavage for 1 week, and then DSS was added to the drinking water for 7 days. MAS was administered for a total of 17 days. The results showed that oral gavage of MAS reduced the disease activity index (DAI), prevented colon shortening, attenuated colon tissue damage and inflammatory response, suppressed colonic oxidative stress and restored the protein expression of intestinal tight junction (TJ) protein (ZO-1, occludin and claudin-3) in mice with DSS-induced colitis. In addition, analysis of 16S rRNA amplicon sequences showed that MAS reduced the DSS-induced intestinal microbiota dysbiosis, including a reduction in Escherichia-Shigella, an increase in Akkermansia, Muribaculaceae and Allobaculum. Collectively, MAS alleviates DSS-induced colitis by maintaining the intestinal barrier, modulating inflammatory cytokines, and improving the microbial community. Full article

(This article belongs to the Special Issue Natural Products Targeting on Oxidative Stress-Related Diseases II)

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