Special Issue "NADPH Oxidases in Metabolic Homeostasis"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 30 April 2019
Metabolic homeostasis is maintained by a tightly regulated balance between energy intake, storage, and utilization. Chronic energy balance surplus results in obesity, leading to the onset of insulin resistance, diabetes, and a variety of metabolic complications. Formerly, the development of these metabolic disturbances was considered to be linked to the production of reactive oxygen species (ROS), inevitably associated with the onset of oxidative stress. Currently, however, the role of ROS is regarded in a more refined fashion. Indeed, ROS produced in physiological quantities, in a timely and spatially regulated manner, are acknowledged as critical physiological regulators of diverse metabolic processes and cellular functions. NADPH oxidases (NOX-es) and dual oxidases (DUOX-es) belong to a family of enzymes with the primary function of ROS production. NOX/DUOX isoforms are present in tissues with prominent roles in the regulation of metabolic homeostasis (e.g., liver, muscle, kidney, white and brown adipose tissues, the hypothalamus, and the islets of the pancreas). In several of these tissues, dysregulated NOX/DUOX expression or activation has been associated with disturbed insulin signaling and metabolic function. Due to their tightly-controlled ROS production, NOX/DUOX enzymes elicit high interest in relation to both metabolic health sustainment and the development of metabolic disorders, and are thus considered to be promising pharmaceutical targets in obesity, insulin resistance, and diabetes.
The aim of this “Special Issue” is to provide a forum for recent research advances regarding the regulatory function of NOX/DUOX isoforms in the maintenance of metabolic balance and their alterations in diabetes and diabetes-related complications.
Dr. Ildiko Szanto
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
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