Next Article in Journal
Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate
Previous Article in Journal
Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models
Article Menu

Export Article

Open AccessReview

H2O2 Metabolism in Normal Thyroid Cells and in Thyroid Tumorigenesis: Focus on NADPH Oxidases

1
Department of Internal Medicine, Division of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, 1205 Geneva, Switzerland
2
Diabetes Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
3
Department of Pathology, Jewish General Hospital and McGill University, Montréal, Québec, QC H3T 1E2, Canada
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(5), 126; https://doi.org/10.3390/antiox8050126
Received: 27 March 2019 / Revised: 18 April 2019 / Accepted: 24 April 2019 / Published: 10 May 2019
(This article belongs to the Special Issue NADPH Oxidases in Metabolic Homeostasis)
  |  
PDF [1999 KB, uploaded 10 May 2019]
  |  

Abstract

Thyroid hormone synthesis requires adequate hydrogen peroxide (H2O2) production that is utilized as an oxidative agent during the synthesis of thyroxin (T4) and triiodothyronine (T3). Thyroid H2O2 is generated by a member of the family of NADPH oxidase enzymes (NOX-es), termed dual oxidase 2 (DUOX2). NOX/DUOX enzymes produce reactive oxygen species (ROS) as their unique enzymatic activity in a timely and spatially regulated manner and therefore, are important regulators of diverse physiological processes. By contrast, dysfunctional NOX/DUOX-derived ROS production is associated with pathological conditions. Inappropriate DUOX2-generated H2O2 production results in thyroid hypofunction in rodent models. Recent studies also indicate that ROS improperly released by NOX4, another member of the NOX family, are involved in thyroid carcinogenesis. This review focuses on the current knowledge concerning the redox regulation of thyroid hormonogenesis and cancer development with a specific emphasis on the NOX and DUOX enzymes in these processes. View Full-Text
Keywords: NADPH oxidase; NOX4; dual oxidase; DUOX2; Thyroid; redox NADPH oxidase; NOX4; dual oxidase; DUOX2; Thyroid; redox
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Szanto, I.; Pusztaszeri, M.; Mavromati, M. H2O2 Metabolism in Normal Thyroid Cells and in Thyroid Tumorigenesis: Focus on NADPH Oxidases. Antioxidants 2019, 8, 126.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top