Lipid-Binding Proteins and Oxidative Stress in Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 5122
Special Issue Editors
Interests: glia; myelination; oxidative stress; apolipoprotein D; lipocalins
Interests: membranes; lipids; adiponectin receptors; lipocalins
Interests: oxidative stress; antioxidation; lipocalins; protein chemistry; alpha-1-microglobulin
Special Issue Information
Dear Colleagues,
Alterations in the homeostasis of lipids due to their oxidation are related to physiological aging; this is a recognized basis for inflammation and many human diseases, such as diabetes, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation by reactive species yields toxic by-products that, in turn, alter the structure and function of many biomolecules. A number of lipid-binding proteins are reported to show antioxidant capabilities, in which different mechanisms are involved. For example, some proteins bind sensitive lipids and shield them to prevent oxidation, whereas other proteins are able to bind oxidized lipids and enzymatically reduce them. Additionally, some protein biological functions are susceptible of the effects of oxidation. It is therefore critical to understand the antioxidant properties of lipid-binding proteins, as well as to evaluate the significance of their oxidative modifications, to properly assay the relevance of extrinsic antioxidants used as therapeutic agents in human diseases.
This Special Issue of Antioxidants seeks to provide an update of this intriguing subject. We aim to assemble original research articles reporting experimental data on the mechanistic roles of lipid-binding proteins when protecting cells against oxidative stress.
We look forward to your contribution and will be very happy to discuss your suggestions.
Dr. Diego Sánchez
Guest Editor
Dr. Bo Åkerström
Dr. Mario Ruiz
Co-Guest Editors
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Keywords
- Lipid-binding proteins
- Oxidative stress
- Lipid oxidation
- Antioxidation
- Heme
- Lipocalins
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