Oxidative Stress in Heart Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 158
Special Issue Editor
2. Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
Interests: antioxidants; cardiovascular diseases; mitochondrial metabolism; muscle contraction; proteasome; proteomics; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress is now recognized as a central driver in the initiation and progression of diverse forms of heart disease, including atherosclerosis, ischemic heart disease, heart failure, and cardiac arrhythmias. Excessive generation of reactive oxygen and nitrogen species, coupled with impaired endogenous antioxidant defenses, alters redox-sensitive signaling pathways, damages cellular macromolecules, and promotes endothelial dysfunction, inflammation, and maladaptive cardiac remodeling. Despite this strong mechanistic and experimental foundation, clinical translation of antioxidant-based therapies has yielded mixed and often disappointing results, underscoring the complexity of redox biology in the cardiovascular system and the need for more targeted, context-specific strategies.
This Special Issue, “Oxidative Stress in Heart Disease,” in Antioxidants aims to bring together original research and comprehensive reviews that clarify how oxidative stress shapes cardiac and vascular pathophysiology across the disease continuum, from subclinical risk states to overt heart failure. We particularly welcome contributions that dissect cellular and mitochondrial sources of reactive oxygen species, define novel redox biomarkers, explore redox-sensitive signaling networks, and evaluate innovative antioxidant or redox-modulating interventions in preclinical and clinical settings. By bringing together original research articles and timely reviews, this Special Issue seeks to provide an updated perspective on how oxidative stress shapes cardiovascular disease and how redox-based approaches may inform future diagnostic and therapeutic innovation.
Prof. Dr. Aldrin V. Gomes
Guest Editor
Manuscript Submission Information
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Keywords
- reactive oxygen species (ROS)
- redox signaling
- ischemia–reperfusion injury
- mitochondrial dysfunction
- cardiac hypertrophy
- myocardial infarction
- oxidative stress
- antioxidant defense
- atherosclerosis
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