Oxidative Stress and Antioxidants in Neurodegenerative Disorders

Dear Colleagues,

Growing evidence has indicated that oxidative stress, mitochondria dysfunction, inflammation, lysosomal dysfunction, protein aggregation, and iron deposition are key factors leading to neuronal death in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and a group of disorders known as neurodegeneration with brain iron accumulation. Most probably, several of these factors interact through positive feedback loops that conclude in neuronal dysfunction and death.

Recent developments link the function of mitochondria, which provides energy for the maintenance of neuronal homeostasis, and lysosomes, the major cellular organelle for iron recycling. Likewise, iron overload has been reported to associate with alterations of mitochondrial function as well as increased oxidative stress, autophagic defects, and diminished lysosomal function. Similarly, a link between iron, the endolysosomal system, and neuroinflammation has recently been proposed, and a positive feedback loop between oxidative stress, α-synuclein aggregation, and mitochondria dysfunction is firmly established.

The understanding of how these different players, mainly oxidative stress, protein aggregation, mitochondrial dysfunction, inflammation, and lysosomes, interact to generate neurodegeneration is an open field of huge importance. Equally relevant is the design of therapeutic strategies based on multifunctional drugs that target several or all these players in order to retard or stop the progress of these diseases.

Prof. Dr. Marco Tulio Núñez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.