Advances for the NO/NOS System
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 10717
Special Issue Editors
Interests: oxidative stress; nitrosative stress; inflammation; nanomedicine
Interests: applied and computational statistics; molecular modeling; genetic analysis; statistical modeling in medicine; integrated health informatics system; medical diagnostic research; statistical inference; medical imaging analysis; assisted decision systems; research ethics; social media and health information; evidence-based medicine
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Special Issue Information
Dear Colleagues,
Following its important discovery, NO has been extensively studied for its important functions in physiological and pathological biological processes. NO acts as a neurotransmitter in the nervous system, facilitates phagocytosis, and contributes to the proper function of the reproductive system. In the vascular system, it has vasodilating effects, contributes to maintaining the integrity of the vascular barrier represented by vascular endothelial cells, prevents the adhesion of platelets and neutrophyls to the vascular wall, and prevents platelet aggregation.
All these effects make it an ideal candidate for thrombotic-process-modulating therapies. On the other hand, the role of NO in nitro-oxidative stress and inflammation is well known, being a specific target for anti-inflammatory therapies.
The enzyme responsible for NO formation in living tissues is represented by NO synthase (NOS). NOS can modulate the availability of NO in various tissues. The interplay between NO and NOS can represent the borderline between physiological and pathological processes. Molecular cloning of constitutive NOS isoforms and functional significance is not yet clear.
The enormous multiplicity of the NO/NOS system in terms of its role as a biological messenger merits further exploration of these molecules and their role in physiological and pathological processes. This Special Issue of Antioxidants aims to provide an update of this interesting and provocative subject.
Prof. Dr. Adriana Elena Bulboaca
Prof. Dr. Sorana D. Bolboacă
Guest Editors
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Keywords
- reactive oxygen species
- nitric oxide
- nitric oxide synthase
- NO/NOS therapies
- aging
- senescence
- NO signaling pathways
- therapeutic agents
- oxidative stress
- inflammation
- phagocytosis
- neurotransmitters
- vasodilators
- antiaggregant molecules
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