Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 8761
Special Issue Editor
Interests: biochemistry; genetics and molecular biology medicine pharmacology; toxicology; pharmaceutics; immunology; microbiology; agricultural and biological sciences; engineering; neuroscience; chemistry; physics and astronomy; environmental science; oxidative stress; diabetic retinopathy; antioxidants; natural products; polyphenols
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetic retinopathy is the main cause of preventable vision loss and blindness in working-age adults. The loss of strict homeostatic glycemic control suffered in diabetes triggers neural and vascular damage to the retina in a complex sequence of events in which oxidative stress is a key factor. Both the direct action of reactive oxygen species on cell biomolecules and that mediated by their ability to enhance inflammatory responses cause damage to the structure and function of the retina. In recent years, the therapeutic strategies for diabetic retinopathy have focused on delaying the progression of the pathology in advanced stages, although previous neural and vascular damages are irreversible. Furthermore, recent studies show different antioxidant therapies to be effective in inhibiting, preventing, or delaying the development and progression of diabetic retinopathy. A thorough understanding of the generation and effects of oxidative stress on the hyperglycemic retina is needed, and of the use of new cellular targets and innovative therapies to prevent the irreversible damages induced in diabetic retinopathy.
We invite authors to submit original research findings, clinical trials, or reviews to this Special Issue, which will bring together current advances regarding the role of oxidative stress in the pathophysiology of diabetic retinopathy and the role of intercellular communication, as well as research related to the identification of novel early diagnostic biomarkers, the use of new therapeutic cellular targets, and the exploration of antioxidant and anti-inflammatory therapies in preventing the development of diabetic retinopathy.
Dr. Ángel Luis Ortega
Guest Editor
Manuscript Submission Information
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Keywords
- diabetic retinopathy
- antioxidants
- natural products
- epigenetic mechanisms
- biomarkers
- inflammation
- vascular dysfunction
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