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Antioxidants
Special Issues
Anti-Inflammatory Agents from Natural Antioxidants: Discovery, Mechanisms, and Therapeutic Potential
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Anti-Inflammatory Agents from Natural Antioxidants: Discovery, Mechanisms, and Therapeutic Potential

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1032

Special Issue Editor

Dr. Young-Chang Cho

E-Mail Website
Guest Editor
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, 77 Yongbong-ro, Gwangju 61186, Republic of Korea
Interests: anti-inflammatory; antioxidants; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress caused by external stimuli is balanced with the antioxidant mechanism in the human body, leading to an appropriate level of inflammatory response, which act as a defense mechanism in the body against external stimuli. However, excess oxidative stress caused by the production of reactive oxygen species (ROS) that exceeds the capacity of antioxidants to counteract the deleterious effects of ROS ultimately induces excessive inflammatory responses, leading to an increase in risks, including chronic inflammatory diseases, cancers, aging. Therefore, research on candidate substances that can suppress the production of ROS and inflammatory reactions is being actively conducted. Synthetic drugs are widely used due to their superior efficacy and economic efficiency, while safety concerns call for the development of natural antioxidants.

This Special Issue provides an update on the beneficial effects of antioxidants and anti-inflammatory agents from natural products and uses various in vitro and in vivo disease models to represent the underlying molecular mechanisms of their biological activity. We invite you to submit your latest research results or review articles.

Potential topics include the isolation of compounds from natural products; the analysis of natural products, and the elucidation of their regulatory mechanism of actions for suppressing oxidative stress and inflammatory responses; and health-enhancing effects of natural products on chronic-oxidative-stress-related and inflammatory diseases.

Dr. Young-Chang Cho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • inflammatory responses
  • antioxidant
  • anti-inflammation
  • anti-aging
  • anticancer
  • natural products

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Published Papers (1 paper)

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Research

18 pages, 6644 KB  
Article
Pulsatilla Saponin B4 Alleviates H2O2-Induced Oxidative Stress and Apoptosis via the AMPK/Nrf2 Pathway in Bovine Mammary Epithelial Cell Models
by Hao Zhang, Shouli Yi, Panpan Ding, Baocheng Hao, Dan Shao and Shengyi Wang
Antioxidants 2026, 15(3), 294; https://doi.org/10.3390/antiox15030294 - 27 Feb 2026
Viewed by 621
Abstract
The elevated metabolic demands of lactation in dairy cows cause an excess of reactive oxygen species (ROS) in the mammary tissue, which disrupts redox homeostasis and ultimately induces oxidative stress. This oxidative stress directly damages mammary epithelial cells, reduces milk yield and quality, [...] Read more.
The elevated metabolic demands of lactation in dairy cows cause an excess of reactive oxygen species (ROS) in the mammary tissue, which disrupts redox homeostasis and ultimately induces oxidative stress. This oxidative stress directly damages mammary epithelial cells, reduces milk yield and quality, and exacerbates oxidative damage in the mammary gland, ultimately leading to significant economic losses. Therefore, alleviating oxidative stress is essential to safeguard the health of dairy cow mammary glands and ensure farming profitability. Pulsatilla saponin B4 (PSB4), a triterpenoid saponin monomer derived from the roots of Pulsatilla chinensis, possesses antioxidant activities. However, its protective effect against oxidative injury in bovine mammary epithelial cells (BMECs) and the exact mechanisms are not fully elucidated. Therefore, this study aims to elucidate the specific protective effects and mechanisms of PSB4 against oxidative damage induced by hydrogen peroxide (H2O2). The results demonstrated that PSB4 effectively alleviates oxidative stress on two fronts: by enhancing the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) to boost total antioxidant capacity (T-AOC), and by significantly reducing malondialdehyde (MDA) levels and suppressing excessive ROS production. Mechanistically, PSB4 primarily functions by enhancing the nuclear relocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulating antioxidant response genes. Furthermore, PSB4 effectively reduced H2O2-induced apoptosis in BMECs, a finding jointly confirmed by JC-1 assay (effectively reversed mitochondrial depolarization) and flow cytometry (showing reduced apoptotic rates). This protective effect was linked to the normalization of apoptosis-associated protein expression, primarily through an increased B-cell lymphoma 2 (BCL2)/BCL2-associated X Protein (Bax) ratio and decreased cysteinyl aspartate-specific proteinase 3 (Caspase-3) expression. Notably, these protective effects of PSB4 could be antagonized by an AMP-activated protein kinase (AMPK)-specific inhibitor (Compound C, CC). Overall, this preliminary study confirms that at the tested concentrations, PSB4 exerts a protective effect against oxidative damage in BMECs, likely through modulation of the AMPK/Nrf2/Caspase-3 signaling axis. These findings provide a rationale for future in vivo studies and support the potential development of PSB4 as a nutritional supplement or therapeutic agent to alleviate oxidative stress and improve mammary health in dairy cows. Full article
(This article belongs to the Special Issue Anti-Inflammatory Agents from Natural Antioxidants: Discovery, Mechanisms, and Therapeutic Potential)
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