Antioxidants from the Sea and Their Application

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 850

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Guest Editor
Institute of Biosciences and BioResources (IBBR), Consiglio Nazionale delle Ricerche (CNR), Via Pietro Castellino 111, I-80131 Naples, Italy
Interests: antarctic and Arctic marine environments; bacteria; fish; sponges; marine natural products; marine peptides/proteins; protein structure/function; hemoproteins; marine antioxidants; marine anti-UV; functional ingredients; cosmeceuticals; PUFA
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Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via F. Acton 55, 80133 Naples, Italy
Interests: microalgae; drug discovery; gene mining; marine biotechnology; transcriptomics
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Special Issue Information

Dear Colleagues,

Marine environments host a variety of organisms that represent a huge reservoir of structurally diverse, biologically active compounds with unique properties. Among molecules, antioxidant compounds play a key role in maintaining cellular redox homeostasis and are involved in the survival of marine organisms exposed to environmental stress.

Marine antioxidants are represented by several compounds such as polyphenols, terpenoids, polyketides, alkaloids, sterols, pigments, polysaccharides, and polyunsaturated fatty acids, as well as peptides and enzymes involved in the protection against oxidative stress.

The aim of this Special Issue is to collect new, high-quality papers, including reviews and articles, on various aspects related to marine antioxidant compounds, including (but not limited to) the following: biosynthesis, mechanisms of action, antioxidant capacity, biotechnological production, and potential applications as new drugs, dietary supplements, and health-care products.

Dr. Daniela Giordano
Dr. Chiara Lauritano
Guest Editors

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Keywords

  • marine natural products
  • marine enzymes
  • marine nutraceuticals
  • marine cosmeceuticals
  • food supplements
  • antioxidant mechanisms of action
  • structure–function relationship
  • antioxidant capacity
  • biotechnological application
  • biotechnological production

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Published Papers (1 paper)

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Research

23 pages, 6313 KB  
Article
Chemical Characterization and Bio-Screening of Neuroprotective Potential of Brazilian Brown Seaweed Canistrocarpus cervicornis in 6-OHDA-Induced Neurotoxicity Model
by Thalisia Cunha dos Santos, Johana Marcela Concha Obando, Joana Silva, Ana Luíza Vidal Pimentel Santos, Roberto Carlos Campos Martins, Diana Negrão Cavalcanti, Rui Pedrosa and Celso Alves
Antioxidants 2025, 14(12), 1403; https://doi.org/10.3390/antiox14121403 - 25 Nov 2025
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Abstract
Brazilian native seaweed Canistrocarpus cervicornis (Ochrophyta, Dictyotaceae) is recognized for its chemodiversity, particularly cyclic diterpenes and polysaccharides, yet its relevance to neurological disorders remains unexplored. This study evaluated the neuroprotective potential of a hydroethanolic extract (ECCH), its polar fraction (CCFPol), a dichloromethane extract [...] Read more.
Brazilian native seaweed Canistrocarpus cervicornis (Ochrophyta, Dictyotaceae) is recognized for its chemodiversity, particularly cyclic diterpenes and polysaccharides, yet its relevance to neurological disorders remains unexplored. This study evaluated the neuroprotective potential of a hydroethanolic extract (ECCH), its polar fraction (CCFPol), a dichloromethane extract (ECCD), and eight derived fractions (CCF1–2, CCF3, CCF4, CCF5–6, CCF7, CCF8–10, and CCF11–15). Cytotoxicity was evaluated in SH-SY5Y neuroblastoma cells, and neuroprotection was examined against 6-OHDA–induced toxicity. The mitochondrial membrane potential, ROS and H2O2 generation assays were conducted to explore the mechanisms underlying the observed effects. Among the key findings, the CCF3 fraction exhibited a high content (75.04%) of dolastane-type diterpenoids. Both CCFPol (100 µg/mL) and CCF3 (1 µg/mL) increased cell viability to 68.43 ± 4.60% and 60.61 ± 0.80%, respectively, compared with 6-OHDA–treated cells (50.70 ± 2.71%). Additionally, CCF3 and CCFPol reduced H2O2 levels (200.0 ± 18.19% and 195.5 ± 16.13%, respectively, vs. 6-OHDA-treated cells: 302.2 ± 17.07%) and lowered intracellular ROS (122.6 ± 22.7% and 129.6 ± 19.4%, respectively, vs. 6-OHDA-treated cells: 153.0 ± 32.7%). This is the first study to demonstrate the neuroprotective potential of the C. cervicornis in a 6-OHDA-induced neurotoxicity cellular model, contributing to the understanding of marine bioactive resources and their relevance for neurological research. Additional studies aimed at isolating the active constituents and clarifying their mechanisms of action will further strengthen and expand the biological relevance of this specie as source of neuroprotective agents. Full article
(This article belongs to the Special Issue Antioxidants from the Sea and Their Application)
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