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Antioxidants
Special Issues
Bioactive Antioxidants from Agri-Food Wastes, 2nd Edition
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Bioactive Antioxidants from Agri-Food Wastes, 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (10 May 2026) | Viewed by 2608

Special Issue Editors

Dr. Mia Kurek

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Guest Editor
Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
Interests: active food packaging; intelligent sensors; antioxidant; smart packaging; barrier properties; shelf-life; food–packaging interaction; waste reduction; biopolymers; recyclability; eco-impact; bioactive compounds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sabina Galus

E-Mail Website
Guest Editor
Department of Food Engineering and Process Management, Institute of Food Sciences, Warsaw University of Life Sciences, 02-776 Warsaw, Poland
Interests: food packaging; edible films and coatings; active packaging; intelligent packaging; smart packaging; new food product development; food engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Tea Sokač Cvetnić

E-Mail
Guest Editor Assistant
Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
Interests: artificial neural network modeling; near-infrared spectroscopy; fermentation quality; NIR spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to deepen the knowledge about the applications of bioactive antioxidants derived from agri-food wastes. In the first edition, mainly production techniques were covered, while in this Issue we aim to focus on the application of bioactives to food and nutraceutics, along with their impact on health.

The use of various matrixes for the delivery of bioactives to the final product could impact their activity; therefore, releasing mechanisms and metabolic pathways will be also taken into account. Since one third of food is wasted globally, there is more than ever the need for the valorization of wasted products.

In addition, there is a research stream for the use of biobased materials used for the preservation of bioactive rich food. Preservation could be achieved either by the use of enriched packaging materials, by their stabilization directly in the product, or in their synergy.

Let’s discover what the topics of interest are of the latest scientific findings using agri-food waste.

Dr. Mia Kurek
Prof. Dr. Sabina Galus
Guest Editors

Dr. Tea Sokač
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • agri-food byproducts
  • waste
  • food industry
  • additives
  • packaging

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Published Papers (3 papers)

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Research

19 pages, 3422 KB  
Article
Protective Effects of Cashew Apple Bagasse and Its Hydroethanolic Extract Against Fatty Liver in Rats
by Susana Hernández-Pérez, Víctor Hugo Oidor-Chan, Jonathan Puente Rivera, Vicente Castrejón-Téllez, Rosa María Oliart-Ros, Elizabeth Carreón-Torres, Luz Ibarra-Lara, Yanet Chávez-Reyes, Diana Catalina Castro-Rodríguez, Patricia Guillermina Mendoza-García, Javier Flores-Estrada and Abril Ramírez-Higuera
Antioxidants 2026, 15(5), 592; https://doi.org/10.3390/antiox15050592 - 7 May 2026
Viewed by 610
Abstract
Cashew apple bagasse (Anacardium occidentale L.) is an agro-industrial byproduct rich in fiber and phytochemicals, yet its effects on diet-induced fatty liver remain insufficiently characterized. This study evaluated the protective effects of cashew apple bagasse (CAB) and its hydroethanolic extract (HECAB) in [...] Read more.
Cashew apple bagasse (Anacardium occidentale L.) is an agro-industrial byproduct rich in fiber and phytochemicals, yet its effects on diet-induced fatty liver remain insufficiently characterized. This study evaluated the protective effects of cashew apple bagasse (CAB) and its hydroethanolic extract (HECAB) in rats fed a high-fat, high-carbohydrate (HFHC) diet. The proximate composition of CAB and the phenolic profile and antioxidant capacity of HECAB were characterized. Male Wistar rats were assigned to four groups and fed for 19 weeks with a standard diet, an HFHC diet, or an HFHC diet supplemented with CAB or HECAB. Anthropometric, biochemical, histological, immunohistochemical, and immunoblot analyses were performed. HECAB showed high phenolic content and marked radical-scavenging activity, and untargeted UPLC-QTOF-MS analysis yielded 12 putative secondary metabolite annotations (levels 3–4) based on accurate mass, isotope distributions, MS/MS fragmentation patterns, and predefined acceptance criteria. Relative to the standard diet group, the HFHC diet induced metabolic and hepatic alterations consistent with early-stage MASLD. Compared with HFHC, both CAB and HECAB reduced serum insulin and HOMA-IR, attenuated hepatic steatosis, increased SOD1 and CAT, and reduced NF-κB, IL-6, TNF-α, and IL-1β, whereas GPx1 remained unchanged. Both interventions also enhanced NRF2 and HO-1 compared to HFHC, with stronger nuclear positivity in the HECAB group, while CAB showed the clearest association with IL-10 restoration. These findings are consistent with modulation of antioxidant defense- and inflammatory-related pathways in early-stage MASLD and support further investigation of cashew apple bagasse as a valorized functional ingredient. However, because classical oxidative damage markers were not measured, these results should not be interpreted as direct evidence of reduced oxidative stress. In addition, the detected metabolites should be interpreted as putative annotations rather than definitive compound identifications. Full article
(This article belongs to the Special Issue Bioactive Antioxidants from Agri-Food Wastes, 2nd Edition)
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21 pages, 4284 KB  
Article
Functionalization of 3D Printed Polylactic Acid by Supercritical CO2 Impregnation with Mango Leaf Extract and Evaluation with Endothelial Colony-Forming Cells and Mesenchymal Stromal Cells
by Ismael Sánchez-Gomar, Mercedes Cáceres-Medina, Cristina Cejudo-Bastante, Casimiro Mantell-Serrano, Lourdes Casas-Cardoso and Mª Carmen Durán-Ruiz
Antioxidants 2026, 15(4), 454; https://doi.org/10.3390/antiox15040454 - 4 Apr 2026
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Abstract
Poly(lactic acid) (PLA) devices can be functionalized with plant-derived bioactives to introduce antioxidant activity while maintaining manufacturability and cytocompatibility. Here, a polyphenol-rich mango leaf extract (MLE) was obtained by enhanced solvent extraction and incorporated into PLA using supercritical carbon dioxide-assisted impregnation. Two manufacturing [...] Read more.
Poly(lactic acid) (PLA) devices can be functionalized with plant-derived bioactives to introduce antioxidant activity while maintaining manufacturability and cytocompatibility. Here, a polyphenol-rich mango leaf extract (MLE) was obtained by enhanced solvent extraction and incorporated into PLA using supercritical carbon dioxide-assisted impregnation. Two manufacturing sequences were compared: impregnation after three-dimensional (3D) printing of discs and impregnation of filaments prior to printing. Extract yield and radical scavenging capacity were quantified, and impregnation efficiency was assessed as a function of pressure and temperature. Biological performance was evaluated using adipose tissue-derived endothelial colony-forming cells (ECFCs) and adipose tissue-derived mesenchymal stromal cells (MSCs), cultured separately and in co-culture on functionalized substrates. Impregnation after printing provided higher and more reproducible loading while preserving disc geometry, whereas impregnation before printing promoted swelling and printing-associated deformation that compromised structural fidelity. Cell-based analyses supported improved adhesion, spatial distribution, and proliferative status on discs produced by impregnation after printing under low-temperature and high-pressure conditions, without evidence of selective loss of either population in co-culture by flow cytometry. These results support post-print supercritical impregnation as a robust route to generate antioxidant, cell-supportive PLA scaffolds from agricultural by-products with potential relevance for vascular-oriented biomedical applications. Full article
(This article belongs to the Special Issue Bioactive Antioxidants from Agri-Food Wastes, 2nd Edition)
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17 pages, 1556 KB  
Article
From Waste to Resource: Extraction and Characterization of Polyphenols from Dalmatian Olive Mill Wastewater
by Nina Knezovic, Ajka Pribisalic, Katarina Jurcic, Ivica Ljubenkov, Barbara Soldo, Danijela Skroza, Mladenka Sarolic, Sanja Luetic, Davorka Sutlovic and Zlatka Knezovic
Antioxidants 2026, 15(1), 12; https://doi.org/10.3390/antiox15010012 - 21 Dec 2025
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Abstract
Background: Olive cultivation and olive oil production are key agricultural sectors in the Dalmatia region, where numerous oil mills operate. Analyses have shown that extra virgin olive oils (EVOO) produced in this area contain respectable amounts of polyphenols, which contribute to superior oil [...] Read more.
Background: Olive cultivation and olive oil production are key agricultural sectors in the Dalmatia region, where numerous oil mills operate. Analyses have shown that extra virgin olive oils (EVOO) produced in this area contain respectable amounts of polyphenols, which contribute to superior oil quality due to their antioxidant properties. During processing, hydrophilic phenolic compounds predominantly transfer into olive mill wastewater (OMW), making it a concentrated source of valuable bioactive molecules. The antioxidant, anti-inflammatory, and photoprotective effects of these polyphenols are highly relevant for cosmetic and pharmaceutical use. Methods: A total of 186 OMW samples were collected from oil mills in the Split-Dalmatia County across three production seasons (2023–2025). Total polyphenol content (TPC) was measured spectrophotometrically, while polyphenol composition was determined by High Performance Liquid Chromatography (HPLC). Antioxidant activity was evaluated using hydrogen atom transfer (HAT; 2,2-diphenyl-1-picrylhydrazyl) (DPPH), electron transfer (ET; ferric reducing antioxidant power) (FRAP), and oxygen radical absorbance capacity assay (ORAC). Results: The obtained results indicated high total polyphenols concentrations, with values ranging from 111.8 to 6717.2 mg of gallic acid equivalents per L of OMW (mg GAe L−1). In the vast majority of analyzed samples, hydroxytyrosol was the predominant phenol compound. The antioxidant activity of the samples was high. Full article
(This article belongs to the Special Issue Bioactive Antioxidants from Agri-Food Wastes, 2nd Edition)
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