Optimizing Antibiotic Treatment: Pharmacokinetics and Clinical Trials

Dear Colleagues,

For the success of an anti-infective therapy as well as the prevention of resistance development, the correct dosage is decisive, in addition to the choice of antibiotic and the duration of therapy. The pharmacological concept of therapy with antibiotics is based on the fact that a sufficient and adequate antibacterial effect is achieved at the site of the bacterial infection. Distribution as a pharmacokinetic process depends on the pharmacological properties of the substances but also on physiological conditions.

Various factors, such as liver or kidney insufficiency as well as obesity, influence the pharmacokinetics of antibiotics to different degrees and often make dose adjustment necessary. Especially in intensive care medicine for the treatment of severe, life-threatening infections, this poses ever new challenges for physicians.

Against this background, well-founded pharmacokinetic information in different patient groups with different influencing factors is essential to ensure adequate antibiotic therapy. This also makes it necessary to determine concentrations in the target tissue. In addition, different dosage regimens such as prolonged and continuous application are of great interest in order to ensure effective antibiotic therapy.

In this Special Issue on “Optimizing Antibiotic Treatment: Pharmacokinetics and Clinical Trials”, the progress made in optimizing antibiotic therapy from a pharmacokinetic perspective and the effects in different clinical areas will be published. The issue welcomes different types of submission, such as original research papers, short communications, reviews, case reports, and perspectives.

Dr. Philipp Simon
Dr. David P. Nicolau 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.