Special Issue "Multi-Drug Resistant Neisseria gonorrhoeae"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (31 May 2018)
Dr. Sidharath Dev Thakur
Department of Veterinary Public Health and Epidemiology, DGCN College of Veterinary and Animal Sciences, Himachal Pradesh Agricultural University, Palampur, Himcahal Pradesh, 176062 India
Interests: Antimicrobial resistance; Neisseria gonorrhoeae; Veterinary Public Health; Zoonoses, Brucella
The prevalence of infections caused by Neisseria gonorrhoeae is rising globally. Coupled with this rise, the ever-present possibility that gonococcal infections will be untreatable in the future has resulted in increased attention by public health agencies worldwide to diagnose infections quickly and to ensure that patients are treated with effective antibiotics.
Over the past 70 years, different antibiotics have been introduced to treat gonococcal infections. Steadily, N. gonorrhoeae has developed an array of resistance mechanisms to each antibiotic. This has resulted in the successive withdrawal of older antibiotics when resistance in gonococcal populations (>5 percent resistant) precludes their effective use. Choices for effective treatment of gonococcal infections are now severely limited. Presently, therapy with an injectable third generation cephaloporin coupled with azithromycin is the globally-recommended treatment for uncomplicated gonococcal infections. Resistance to both of these antibiotics has been reported, along with treatment failure using dual therapy.
The present Special Issue will seek to highlight the most recent information and advances on antimicrobial resistant N. gonorrhoeae. To combat drug resistance, improvements in simple, inexpensive and rapid diagnostics for gonorrhea infections are needed. Surveillance is required to establish local and regional antimicrobial resistance profiles to advise on treatment regimens which reflect local conditions. The molecular epidemiology of resistant isolates should be better monitored globally to ascertain the dispersal of common resistant strains and the introduction of new phenotypes. New diagnostic methods for antimicrobial resistance (AMR) must be developed and evaluated as many regions of the world have no capacity for diagnostic or antimicrobial susceptibility (AMS) testing of N. gonorrhoeae using presently-recommended methods. Further, the widespread use of nucleic acid amplification tests for diagnosing N. gonorrhoeae infections in resource-rich areas precludes AMS testing because culture of the organism is not possible. In this Special Issue, we hope to highlight advances that lead to a better understanding of AMR in N. gonorrhoeae, as well as strategies being developed to advance effective treatment, including the development of point-of-care tests.
Suggested topics for consideration include:
- Advances in national and international surveillance of antibiotic resistant N. gonorrhoeae isolates
- Molecular epidemiology of resistant isolates
- Advances in new technologies and/or molecular detection of AMR
- Point-of-care testing for N. gonorrhoeae and its AMR
- New antimicrobial agents for treating gonococcal infections
- Whole genome sequencing as a strategy to understand gonococcal AMR and transmission
- Identification of sexual networks for AMR transmission
- Will a gonococcal vaccine end the AMR crisis?
- Modelling gonococcal AMR—does one size fit all?
- Effect of co-infections on gonococcal AMR
Prof. Dr. Jo-Anne R. Dillon
Dr. Sidharath Dev Thakur
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- N. gonorrhoeae
- antimicrobial susceptibility
- molecular epidemiology
- mechanisms of resistance
- molecular tests/point-of-care
- new AMS technologies