Special Issue "Diagnosis and Treatment of Fungal Infections"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 15 April 2022.

Special Issue Editors

Dr. Dominik Łagowski
E-Mail Website
Guest Editor
Sub-department of Veterinary Microbiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland
Interests: dermatophytes; antifungal resistance mechanisms; veterinary mycology; antifungals; drug susceptibility of fungi; pathogenesis of fungal infections
Dr. Sebastian Gnat
E-Mail Website
Guest Editor
Department of Veterinary Microbiology, Institute of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin, Poland
Interests: antifungals; antifungals resistance mechanisms; fungal zoonoses; natural antimycotics; asymptomatic carriers in animals; public health
Special Issues, Collections and Topics in MDPI journals
Dr. Mariusz Dyląg
E-Mail Website
Guest Editor
Department of Mycology and Genetics, Faculty of Biological Sciences, University of Wroclaw, 51-148 Wroclaw, Poland
Interests: mycology; fungal pathogens; virulence factors; conventional and molecular identification of fungi; Cryptococcus; Malassezia; etiological factors of dermatomycoses; antifungals; mechanisms of resistance; evolution of determinants of fungal pathogenicity
Special Issues, Collections and Topics in MDPI journals
Dr. Aneta Nowakiewicz
E-Mail Website
Guest Editor
Sub-Department of Veterinary Microbiology,Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland
Interests: antimicrobial resistance mechanisms; wildlife zoonoses; indicator bacteria; livestock impact on environment; antimicrobial resistance circulation; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

Paradoxically, despite the progress in medicine, the prevalence of fungal infections is increasing each year, and the therapeutic measures available at the beginning of the third millennium are still highly limited. The first concerns about the increasing prevalence of fungal infections emerged in the first decades of the 20th century, ascribed to various environmental factors and anthropopressure. Consequently, the first therapeutic attempts to treat these infections were undertaken.

Although pathogenic fungi are one of the oldest groups of microorganisms, they were not part of any stable taxonomic system for a long time. Given the enormous number of taxonomic differences between related fungal pathogens and the importance of species-level identification, the gold standard to use for routine identification of dermatophytes has become the subject of an ongoing debate, and microbiologists' opinions are still inconsistent. Hence, currently reliable establishment of the boundaries of fungal species and, thus, accurate species identification require a multidirectional approach, as it is easy to make a mistake in diagnosis. The importance of correct identification of the etiological factor of mycosis is most clearly appreciated when treatment fails. However, the inefficiency of therapy applied in the course of fungal infections may have many more causes than only the wrong diagnosis.

Historically, the first antifungal drugs were limited to nonspecific agents, e.g., iodide, mercury, benzoic and salicylic acids, phenol derivatives, undecylenic acid, methyl violet, sulfonamide derivatives, and other factors, with usually harmful effects on human health such as preparations based on bromine, potassium permanganate, and turpentine oil mixed with olive oil. The interest in clinical antifungal therapy has gradually increased since then, although the rate of development of antifungal drugs has been very slow to date. Despite the availability of at least a few classes of antifungal drugs intended for clinical use, they have a limited spectrum of accessible cellular targets. Nowadays, the search for synthetic and natural chemical compounds that may constitute new therapeutic options due to their antifungal activity against pathogenic fungi fits in the concept of finding the “holy grail” in antifungal therapy. Another problem resulting from the widespread use of antifungal drugs, and related to the overlapping mechanisms of action and identical cellular targets, is the emergence of multidrug resistance (MDR) phenotypes in an increasing number of pathogenic fungi. Hence, in vitro tests of antifungal drugs and a description of the mechanisms contributing to this emerging resistance are the present tasks for the mycologist milieu.

In the context of the increase in new literature focused on the diagnostics and therapy of fungal infections, this Special Issue is being launched. The aim is to provide a single source to showcase the highlights of new and up-to-date research from all areas of clinical and veterinary diagnostics and therapy for fungal infectious disease.

Dr. Dominik Łagowski
Dr. Sebastian Gnat
Dr. Mariusz Dyląg
Dr. Aneta Nowakiewicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifungal therapy
  • fungi
  • qPCR
  • dermatophytes
  • drug susceptibility
  • Cryptococcus
  • Malassezia
  • mechanisms of resistance
  • MALDI/TOF
  • natural antimycotics
  • molds
  • fungal infection
  • antigen detection
  • molecular detection
  • invasive fungal infections

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Use of microsatellite markers to reveal the genetic variability of Microsporum canis from different hosts and geographic origins
Authors: Andrea Peano; Yvonne Gräser; Jacques Guillot; Paolo Tizzani; Elisa Chiavassa; Anna Rita Molinar Min; Patrizia Danesi; Roberta Galuppi; Mario Pasquetti
Affiliation: Dipartimento di Scienze Veterinarie, Università di Torino, Italy Institute of Microbiology and Hygiene, Universitätsmedizin Berlin – Charité, Hindenburgdamm 27, D-12203, Berlin, Germany Dynamyc, UMR BIPAR, Ecole Nationale Vétérinaire d’Alfort, Maisons-Alfort, France

Title: Diagnosis and treatment of invasive candidiasis
Authors: Barantsevich E. P.; Barantsevich N. E.
Affiliation: Almazov national medical research centre, Saint-Petersburg, Russia

Back to TopTop