Carbapenemases in Gram-Negative Bacteria: A Global Health Threat and Therapeutic Challenge
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3762
Special Issue Editors
Interests: b-lactamases; carbapenemase
Interests: infectious diseases; bacteriology; AMR; gram-negative; klebsiella pneumoniae
2. Food Hygiene and Control, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt
Interests: antibiotic resistance; one health; rapid diagnostics; susceptibility testing; gram negatives; genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The World Health Organization (WHO) has identified antimicrobial resistance (AMR) as a major global public health threat, ranking it among the top ten challenges humanity will face in the next decade. Of particular concern is the rapid rise of AMR coupled with a decline in the development of new antimicrobial drugs. Recently, the WHO published a list of pathogenic bacteria urgently requiring new antimicrobials, with carbapenem-resistant Gram-negative bacterial pathogens, including Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacteriaceae, placed in the “critical” priority category 1. Among the mechanisms causing carbapenem-resistance, carbapenemase-production stands out as a critical factor, as it confers bacteria with resistance towards classical beta-lactam antibiotics and often occurs in combination with mechanisms causing resistance towards other antibiotic classes. This Special Issue seeks manuscript submissions reporting on the epidemiology of carbapenemase-production in Enterobacterales, P. aeruginosa and A. baumannii, their susceptibility towards novel antimicrobial options as well as towards old antibiotics, alone or in combination with conventional antibacterial compounds. Also being considered for publication are manuscripts reporting on the performance of novel phenotypic and immunological as well molecular detection and characterization methods of carbapenemases, providing crucial insights for the scientific community and healthcare practitioners in the relentless battle against antimicrobial resistance.
Dr. Stefano Mancini
Dr. Diego O. Andrey
Dr. Mustafa Sadek
Guest Editors
Manuscript Submission Information
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Keywords
- carbapenemase-producing Enterobacteriaceae (CPE)
- carbapenemase-producing Pseudomonas aeruginosa (CPPA)
- carbapenemase-producing Acinetobacter baumannii (CPAB)
- antimicrobial susceptibility of CPE, CPPA or/and CPAB
- carbapenemase detection
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