Advances in Antimicrobial Compounds: Exploring Natural, Synthetic, and Repositioned Drugs
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "The Global Need for Effective Antibiotics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 92
Special Issue Editors
Interests: biological active compounds; antimicrobials; antiarrhythmics; anticancers; melatonergic drugs; voltage-gated sodium channel blockers
Special Issues, Collections and Topics in MDPI journals
Interests: antimicrobial activity; natural products; synthetic agents; drug repositioning; synergistic approaches
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, the growing threat of antimicrobial resistance has driven intensive research into new compounds capable of effectively combating infections. This Special Issue, titled "Advances in Antimicrobial Compounds: Exploring Natural, Synthetic, and Repositioned Drugs", aims to gather innovative contributions spanning natural molecules, new synthetic agents with antimicrobial activity, and the repositioning of existing drugs for novel therapeutic applications. Natural products have historically been a rich source of antimicrobial compounds, providing structural diversity and unique mechanisms of action that continue to inspire drug development. Drug repositioning, or repurposing, i.e., identifying new antimicrobial applications for existing drugs that were initially developed for other diseases, is an alternative approach that offers significant advantages, including reduced development costs and accelerated regulatory approval, as the safety profiles of these compounds are often already well established. Additionally, synergy-based approaches—such as combining natural products with synthetic agents—are gaining attention for their potential to enhance efficacy, reduce toxicity, and mitigate resistance development. Original research articles, critical reviews, and methodological studies that explore aspects such as the design of new compounds, the assessment of their efficacy and safety, and the analysis of their mechanisms of action are welcomed. We also encourage contributions that investigate innovative approaches to overcoming the challenges posed by antimicrobial resistance, with the hope of stimulating the development of more effective and sustainable therapies for the future.
Dr. Alessia Carocci
Dr. Alexia Barbarossa
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antimicrobial compounds
- natural products
- synthetic agents
- drug repositioning
- antimicrobial resistance
- synergistic approaches
- mechanisms of action
- drug development
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