Polymer-Based Dressings for Skin Regeneration and Wound Dressing Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 646

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa
Interests: polymer-based drug delivery systems; wound dressings; organic synthesis; antimalarials; anticancer; polymer–drug conjugates
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemistry, Nelson Mandela University, P.O. Box 77000, Port Elizabeth 6001, South Africa
Interests: polymers; nanoparticles; wound dressings; skin regeneration; nanofibers; membranes; hydrogels; essential oils; anticancer drugs; antimalarials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The delayed process of wound healing and skin regeneration remains a great challenge in the treatment of wounds, despite the numerous commercially available wound dressing products. The factors that result in delayed skin wound repair are systematic (e.g., diabetes mellitus, obesity, smoking, chemotherapy, aging, and malnutrition) and local (e.g., infections, foreign substance invasion, and oxygenation). Wound dressing materials that are based on biopolymers are potential candidates due to their interesting properties that promote the acceleration of wound healing and skin regeneration. These properties include excellent biodegradability and biocompatibility, non-toxicity, low antigenicity, and the capability to induce cell migration and proliferation. However, biopolymer-based wound dressings suffer from poor mechanical performance, which can be addressed by combining them with synthetic polymers to produce hybrid wound dressings. The polymer-based materials can be formulated into different forms, such as hydrogels, nanofibers, films, membranes, foams, wafers, sponges/bandages, and composites, depending on the nature of the wound. These wound dressing scaffolds can be loaded with bioactive agents such as antibiotics, essential oils, growth factors, vitamins, and others to improve their biological activities. This Special Issue aims to highlight the potential outcomes of polymer-based wound dressing materials from the preclinical and clinical trials of wound healing and skin regeneration.

Prof. Dr. Blessing Atim Aderibigbe
Dr. Sibusiso Alven
Guest Editors

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Keywords

  • wound healing
  • skin regeneration
  • chronic wounds
  • wound dressings
  • biopolymers
  • synthetic polymers
  • nanofibers
  • hydrogels
  • films
  • sponges
  • wafer
  • foams
  • composites
  • bioactive agents
  • self-healing materials
  • nanomaterials
  • advanced materials
  • hydrocolloids
  • 3D printing
  • polymeric microneedles
  • biopolymers
  • antibacterial activity
  • essential oils

Published Papers (1 paper)

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Research

20 pages, 9425 KiB  
Article
Co-Delivery of Dragon’s Blood and Alkanna tinctoria Extracts Using Electrospun Nanofibers: In Vitro and In Vivo Wound Healing Evaluation in Diabetic Rat Model
by Rana Y. AlMotawa, Ghadeer Alhamid, Mohamed M. Badran, Raha Orfali, Abdullah H. Alomrani, Essam A. Tawfik, Dunia A. Alzahrani, Haya A. Alfassam, Safina Ghaffar, Amany Fathaddin, Areej Al-Taweel and Aliyah Almomen
Pharmaceutics 2024, 16(6), 704; https://doi.org/10.3390/pharmaceutics16060704 - 24 May 2024
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Abstract
The increasing prevalence of diabetic wounds presents a significant challenge due to the difficulty of natural healing and various obstacles. Dragon’s blood (DB) and Alkanna tinctoria (AT) are well recognized for their potent healing abilities, which include potent antibacterial and anti-inflammatory activities. In [...] Read more.
The increasing prevalence of diabetic wounds presents a significant challenge due to the difficulty of natural healing and various obstacles. Dragon’s blood (DB) and Alkanna tinctoria (AT) are well recognized for their potent healing abilities, which include potent antibacterial and anti-inflammatory activities. In this study, electrospun nanofibers (NFs) based on polyvinyl pyrrolidone (PVP) were co-loaded with both DB and AT, aiming to magnify their efficacy as wound-dressing applications for diabetic wound healing. The evaluation of these NFs as wound dressings was conducted using a streptozotocin-induced diabetic rat model. Electrospun NFs were prepared using the electrospinning of the PVP polymer, resulting in nanofibers with consistent, smooth surfaces. The loading capacity (LC) of AT and DB into NFs was 64.1 and 70.4 µg/mg, respectively, while in the co-loaded NFs, LC was 49.6 for AT and 57.2 µg/mg for DB. In addition, X-ray diffraction (XRD) revealed that DB and AT were amorphously dispersed within the NFs. Top of Form The loaded NFs showed a dissolution time of 30 s in PBS (pH 7.4), which facilitated the release of AT and DB (25–38% after 10 min), followed by a complete release achieved after 180 min. The antibacterial evaluation demonstrated that the DB-AT mixture had potent activity against Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). Along with that, the DB-AT NFs showed effective growth inhibition for both P. aeruginosa and S. aureus compared to the control NFs. Moreover, wound healing was evaluated in vivo in diabetic Wistar rats over 14 days. The results revealed that the DB-AT NFs improved wound healing within 14 days significantly compared to the other groups. These results highlight the potential application of the developed DB-AT NFs in wound healing management, particularly in diabetic wounds. Full article
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