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Antibiotics
Special Issues
The Century-Long Journey of Peptide-Based Drugs
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Special Issue "The Century-Long Journey of Peptide-Based Drugs"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 3376

Special Issue Editor

Dr. José Rafael De Almeida

E-Mail Website
Guest Editor
Biomolecules Discovery Group, Universidad Regional Amazónica Ikiam, Km 8 Via Muyuna, Tena 150101, Ecuador
Interests: peptides; venomics; machine learning; toxins; anti-infective agents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peptides are low-molecular-weight bioactive molecules with multidimensional biological properties. The first injection of insulin in 1922 marked the beginning of the era of therapeutic peptides. Developing peptide-based drugs is challenging and characterized by several obstacles, such as low oral bioavailability and a short half-life. In contrast, the current landscape of peptides in the pharmaceutical industry has shown many applications of these molecules, leading to increased FDA drug approval and generating billions in revenue. The development of technologies for the rational design and screening of the biological and toxic potential of these small molecules has garnered significant interest among biotechnology-based and medical companies. This Special Issue seeks to bring together a collection of therapeutic and biotechnological applications of natural and synthetic peptides to showcase the latest advances in this field. We invite you to submit an original article, short communication, or review article to this Special Issue, focusing on the whole spectrum of therapeutic peptides.

Dr. José Rafael De Almeida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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Article
Mechanisms of Antimicrobial Peptides from Bagasse against Human Pathogenic Bacteria
by
Thitiporn Ditsawanon
,
Narumon Phaonakrob
and
Sittiruk Roytrakul
Antibiotics 2023, 12(3), 448; https://doi.org/10.3390/antibiotics12030448 - 23 Feb 2023
Viewed by 675
Abstract
Nonedible agricultural wastes (agricultural wastes, agro-industrial wastes, and fishery wastes) were chosen as potential sources of antimicrobial peptides and evaluated for antibacterial efficiency against human pathogens. Specifically, protein hydrolysates were first obtained by hydrolysis with pepsin. Filtrated peptides smaller than 3 kDa were [...] Read more.
Nonedible agricultural wastes (agricultural wastes, agro-industrial wastes, and fishery wastes) were chosen as potential sources of antimicrobial peptides and evaluated for antibacterial efficiency against human pathogens. Specifically, protein hydrolysates were first obtained by hydrolysis with pepsin. Filtrated peptides smaller than 3 kDa were then purified by C18 reversed-phase chromatography, cation exchange chromatography, and off-gel fractionation. NanoLC-MS/MS was used to investigate the amino acid sequences of active peptide candidates. Five candidate peptides were finally chosen for chemical synthesis and evaluation of growth inhibition against human pathogenic bacteria. Two synthetic peptides from bagasse, NLWSNEINQDMAEF (Asn-Leu-Trp-Ser-Asn-Glu-Ile-Asn-Gln-Asp-Met-Ala-Glu-Phe) and VSNCL (Val-Ser-Asn-Cys-Leu), showed the most potent antibacterial activity against three pathogens: Pseudomonas aeruginosa, Bacillus subtilis, and Burkholderia cepacia. The antibacterial mechanisms of these peptides were then examined using shotgun proteomics, which revealed their effects to involve both intracellular-active and membrane-active mechanisms. Further investigation and modification of peptides are needed to increase the efficiency of these peptides against human pathogens. Full article
(This article belongs to the Special Issue The Century-Long Journey of Peptide-Based Drugs)
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Review

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Review
Natural and Man-Made Cyclic Peptide-Based Antibiotics
by
Shian Lai
,
Quan Zhang
and
Lin Jin
Antibiotics 2023, 12(1), 42; https://doi.org/10.3390/antibiotics12010042 - 27 Dec 2022
Cited by 1 | Viewed by 1196
Abstract
In recent years, an increasing number of drug-resistant bacterial strains have been identified due to the abuse of antibiotics, which seriously threatens human and animal health. Antimicrobial peptides (AMPs) have become one of the most effective weapons to solve this problem. AMPs have [...] Read more.
In recent years, an increasing number of drug-resistant bacterial strains have been identified due to the abuse of antibiotics, which seriously threatens human and animal health. Antimicrobial peptides (AMPs) have become one of the most effective weapons to solve this problem. AMPs have little tendency to induce drug resistance and have outstanding antimicrobial effects. The study of AMPs, especially cyclic peptides, has become a hot topic. Among them, macrocyclic AMPs have received extensive attention. This mini-review discusses the structures and functions of the dominant cyclic natural and synthetic AMPs and provides a little outlook on the future direction of cyclic AMPs. Full article
(This article belongs to the Special Issue The Century-Long Journey of Peptide-Based Drugs)
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Review
Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens
by
Gabriela Silva Cruz
,
Ariane Teixeira dos Santos
,
Erika Helena Salles de Brito
and
Gandhi Rádis-Baptista
Antibiotics 2022, 11(12), 1772; https://doi.org/10.3390/antibiotics11121772 - 08 Dec 2022
Cited by 1 | Viewed by 1004
Abstract
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is often limited. In addition to this primordial activity of [...] Read more.
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is often limited. In addition to this primordial activity of cell penetration without membrane disruption, multivalent antimicrobial activity accompanies some CPPs. Antimicrobial peptides (AMPs) with cell-penetrability exert their effect intracellularly, and they are of great interest. CPPs with antimicrobial activity (CPAPs) comprise a particular class of bioactive peptides that arise as promising agents against difficult-to-treat intracellular infections. This short review aims to present the antibacterial, antiparasitic, and antiviral effects of various cell-penetrating antimicrobial peptides currently documented. Examples include the antimicrobial effects of different CPAPs against bacteria that can propagate intracellularly, like Staphylococcus sp., Streptococcus sp., Chlamydia trachomatis, Escherichia coli, Mycobacterium sp., Listeria sp., Salmonella sp. among others. CPAPs with antiviral effects that interfere with the intracellular replication of HIV, hepatitis B, HPV, and herpes virus. Additionally, CPAPs with activity against protozoa of the genera Leishmania, Trypanosoma, and Plasmodium, the etiological agents of Leishmaniasis, Chagas’ Disease, and Malaria, respectively. The information provided in this review emphasizes the potential of multivalent CPAPs, with anti-infective properties for application against various intracellular infections. So far, CPAPs bear a promise of druggability for the translational medical use of CPPs alone or in combination with chemotherapeutics. Moreover, CPAPs could be an exciting alternative for pharmaceutical design and treating intracellular infectious diseases. Full article
(This article belongs to the Special Issue The Century-Long Journey of Peptide-Based Drugs)
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