Special Issue "Therapeutics and Advanced Veterinary Care"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editor

Prof. Dr. Paul Mills
E-Mail Website
Guest Editor
School of Veterinary Science, Faculty of Science, The University of Queensland, Brisbane, Australia
Interests: transdermal drug delivery; pulmonary therapeutics and the control of inflammation; wildlife ecology and therapeutics

Special Issue Information

Dear Colleagues,

The human–animal bond develops over the life of a companion animal, and indeed, the companion animal is often considered a member of the family in many households. This attachment may therefore complicate decisions towards the end of the animal’s life, as to whether to prolong life (“where there is life, there is hope”) or to determine when quality of life has deteriorated to a point where euthanasia is the most humane option. Other factors further complicating these decisions are the challenge of assessing quality of life in different species, and the increasing therapeutic arsenal available to treat the many conditions associated with older age. This Special Issue will therefore focus on the therapeutics that may prolong life and/or enhance the quality of life to determine if and when intervention should be considered.

Prof. Dr. Paul Mills
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality of life
  • euthanasia
  • age-related dysfunction
  • advanced care
  • veterinary ethics

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Evaluation of a Tasteless Enrofloxacin Pharmaceutical Preparation for Cats. Naive Pooled-Sample Approach to Study Its Pharmacokinetics
Animals 2021, 11(8), 2312; https://doi.org/10.3390/ani11082312 - 05 Aug 2021
Viewed by 547
Abstract
Available pharmaceutical preparations of enrofloxacin injected SC or IM to cats are likely to cause adverse tissue reactions in the injection sites (pH of the drug preparations is ≥10.4). Tablets often induce abundant ptyalism and vomiting, casting doubt on the efficacy of the [...] Read more.
Available pharmaceutical preparations of enrofloxacin injected SC or IM to cats are likely to cause adverse tissue reactions in the injection sites (pH of the drug preparations is ≥10.4). Tablets often induce abundant ptyalism and vomiting, casting doubt on the efficacy of the drug administration maneuver. In addition, the reported oral bioavailability is very low. In this trial, the oral pharmacokinetics of dried alginate beads of enrofloxacin (DABE) administered by concealing them in the cat’s moist food or morsels, is described. A naïve polled sampling approach was chosen with fourteen adult healthy cats. Neither their housing nor their feeding habits were altered. A single pharmacokinetic profile was obtained with 5 samples per designated bleeding time, sampling each cat 2–3 times only. None of the cats rejected their medicated food or morsels. Plasma profile of enrofloxacin exhibited an AUC0–24 value of 12.4 µg·h/mL and an AUC0–∞ value of 19.2 µg·h/mL, which are comparatively greater than values previously referred for kittens. In contrast, λ and elimination t½ were almost identical (0.12 1/h and 6.1 h). Pharmacokinetics/pharmacodynamics ratios taking the breakpoint of Staphylococcus epidermidis as a surrogate (0.5 µg/mL), can be regarded as borderline or low, but perhaps adequate in cats, as higher concentrations may be linked to toxicity (AUC0–24/MIC = 24.8; Cmax/MIC = 4.6). Full article
(This article belongs to the Special Issue Therapeutics and Advanced Veterinary Care)
Show Figures

Figure 1

Back to TopTop