Bacterial Disease Research in Livestock and Poultry

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal System and Management".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2734

Special Issue Editor


E-Mail Website
Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China
Interests: molecular pathogens and immunology of livestock and poultry; co-infection and synergistic pathogenic mechanism of pathogens; antibiotic-resistance; quorum sensing systems; biofilms; phage-microbe interaction; antimicrobial agents; plant extracts
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bacterial infections remain a critical threat to livestock and poultry health, welfare, and productivity worldwide, posing significant risks to food security, economic stability, and public health through zoonotic transmission and antimicrobial resistance (AMR). This Special Issue, “Bacterial Disease Research in Livestock and Poultry”, seeks to compile cutting-edge research addressing the multifaceted challenges of bacterial diseases in these vital animal sectors.

We enthusiastically welcome researchers to submit their original research and review articles, brief research reports, and opinions. The potential themes covered by this Special Issue include, but are not limited to, the following:

  • Antimicrobial resistance, virulence, pathogenicity, and transmission mechanisms of bacterial diseases in livestock and poultry;
  • Emerging and endemic bacterial infections in livestock and poultry;
  • Development of accurate typing methods to track the dissemination of zoonotic bacteria;
  • Development of sustainable detection methods to tackle bacterial infections in livestock and poultry;
  • Development of effective vaccines to prevent bacterial diseases in livestock and poultry;
  • Development of novel antibacterial agents—encompassing natural products, small-molecule compounds, bacteriophages, and other therapeutic modalities—to counteract pathogen-mediated antimicrobial resistance and virulence.

Prof. Dr. Yang Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • livestock and poultry
  • antimicrobial resistance
  • pathogenesis
  • antimicrobial agents
  • pathogen detection methods
  • vaccines
  • phage
  • plant extracts

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 17450 KB  
Article
Integrated Single-Cell and Bulk Transcriptomics Unveils Immune Profiles in Chick Erythroid Cells upon Avian Pathogenic Escherichia coli Infection
by Fujuan Cai, Xianjue Wang, Chunzhi Wang, Yuzhen Wang and Wenguang Zhang
Animals 2026, 16(2), 179; https://doi.org/10.3390/ani16020179 - 7 Jan 2026
Viewed by 819
Abstract
Nucleated erythroid cells (NECs) have emerged as active participants in immune responses in addition to their canonical oxygen transport function. The subpopulations and immune heterogeneity of chick erythroid cells (ch-ECs) upon infection have not been fully characterized. Single-cell RNA sequencing (scRNA-seq) was used [...] Read more.
Nucleated erythroid cells (NECs) have emerged as active participants in immune responses in addition to their canonical oxygen transport function. The subpopulations and immune heterogeneity of chick erythroid cells (ch-ECs) upon infection have not been fully characterized. Single-cell RNA sequencing (scRNA-seq) was used to profile ch-ECs in chicks infected with avian pathogenic Escherichia coli (APEC). Unsupervised clustering uncovered ten distinct ch-EC subpopulations (C1–C10), with significant compositional shifts between infected and control groups. Pseudotime analysis revealed a developmental continuum: C1, C3, C5, and C9 as early progenitors; C2, C4, C6, C7, and C10 as mature erythroid cells; and C8 as a naive population. We revealed 62 immune-related genes, including protein kinases and heat shock proteins, and subpopulation-specific differentially expressed genes (DEGs) linked to immune functions. SCENIC analysis revealed Fos, Srf, and Stat3 as key transcription factors with elevated regulon activity and specificity following infection. Subpopulations C2, C4, C6, and C7, which exhibited marked abundance changes, were scrutinized for immune relevance through integrated multi-omics analysis. Immune-related genes including FOS, AKAP9, HS6ST1, GAB3, TFRC, HSPA8, HSP90AA1, and DNAJB6 were identified. Enrichment analysis indicated activation of the MHC class I antigen presentation pathway, while pathways such as Mitogen-Activated Protein Kinase (MAPK) signaling, NOD-like receptor (NLR) signaling, and the heat shock response were found to be suppressed. In conclusion, this study delineates the immune gene repertoire and signaling networks of ch-ECs during APEC infection, offering new perspectives on NEC immunoregulatory functions. Full article
(This article belongs to the Special Issue Bacterial Disease Research in Livestock and Poultry)
Show Figures

Figure 1

17 pages, 1518 KB  
Article
Molecular Characterization and Antibiotic Resistance of Avian Pathogenic Escherichia coli (APEC) Isolates from Broiler Chickens in Algeria
by Ismail Boulbair, Jiangang Hu, Abdelhamid Hammoudi, Beibei Zhang, Saad Aissat, Xinyu Wang, Mohammed Foudil and Shaohui Wang
Animals 2025, 15(22), 3324; https://doi.org/10.3390/ani15223324 - 18 Nov 2025
Cited by 1 | Viewed by 1474
Abstract
Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, a disease responsible for high morbidity and mortality in commercial poultry flocks, leading to devastating economic losses to the poultry industry worldwide. APEC may also act as a source of virulence and antibiotic resistance genes [...] Read more.
Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, a disease responsible for high morbidity and mortality in commercial poultry flocks, leading to devastating economic losses to the poultry industry worldwide. APEC may also act as a source of virulence and antibiotic resistance genes that can be transferred to other Escherichia coli pathotypes. Therefore, this study aimed to determine the serotypes, phylogenetic background, virulence genes, and antibiotic resistance profiles of APEC in Algeria. A total of 98 APEC strains were isolated from chicken samples with characteristic colibacillosis signs between 2019 and 2020. O-serotyping identified O157 (20.41%) and O78 (11.22%) as the predominant serotypes. The isolates were classified into groups B1 (43.87%), C (29.59%), A (12.24%), E (7.14%), F (5.10%), and B2 (2.04%). Virulence gene analysis revealed that among the 31 genes investigated, a high occurrence of mat, crlA (100% each), yijP (98.98%), fimC, ibeB, ompA (97.96% each), iucD (89.80%), iroN (81.63%), iss (80.61%), and eae (79.59%) was observed. The highest resistance rates were found for ampicillin (97.96%), amoxicillin–clavulanic acid (96.94%), nalidixic acid (94.90%), tetracycline (90.82%), and ciprofloxacin (79.59%). Additionally, 92.86% of APEC isolates were resistant to three or more antibiotics, reflecting extensive antimicrobial use in Algerian poultry farms and highlighting a major challenge for animal health management and a potential risk of zoonotic transmission. Our data provide valuable insights into the characteristics of the APEC populations in broiler chickens in Algeria. This may assist in understanding APEC pathogenesis and in developing effective control strategies. Full article
(This article belongs to the Special Issue Bacterial Disease Research in Livestock and Poultry)
Show Figures

Figure 1

Back to TopTop