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Microbiology Research
Special Issues
Zoonotic Bacteria: Infection, Pathogenesis and Drugs—Second Edition
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Zoonotic Bacteria: Infection, Pathogenesis and Drugs—Second Edition

A special issue of Microbiology Research (ISSN 2036-7481).

Deadline for manuscript submissions: 30 December 2025 | Viewed by 128

Special Issue Editors

Prof. Dr. Yang Wang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China
Interests: bacterial pathogenesis; virulence; bacterial protein; antimicrobial drug discovery; vaccine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Shaohui Wang

E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: Escherichia coli; Salmonella; epidemiology; detection; pathogenic mechanism; innate immunity; vaccines; bacteriophage
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Zoonotic Bacteria: Infection, Pathogenesis and Drugs” (https://www.mdpi.com/si/128254).

Zoonotic pathogens have always posed a serious threat to global public health security and agricultural production. More than 60% of all known human pathogens are zoonotic, and 75% of all emerging infectious diseases are caused by zoonoses. Many factors, including geographical demographics, environment, and social characteristics such as the indiscriminate and increased use of antibiotics in animal husbandry, have combined to promote the spread of zoonotic diseases. The “One Health” approach advocates for the linking of human health, animal health, and the environment. With regard to zoonotic bacterial pathogens, the emergence and extensive spread of multidrug-resistant bacteria of animal origin has alerted us to the dangers of antibiotic use in animals worldwide. Currently, medical and veterinary research is engaged in effectively controlling the spread of zoonotic pathogens, interfering with the pathogenic process, and curbing the development of antibiotic resistance. This Special Issue welcomes original research articles and relevant reviews focusing on the bacterial epidemiology of zoonotic bacteria, their pathogenesis, research on vaccine development, the mechanisms behind antibiotic resistance and the anti-virulence therapies of alternative antibiotics, and other strategies to curb the development of antibiotic resistance, especially those that link their results to practical applications.

Prof. Dr. Yang Wang
Prof. Dr. Shaohui Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microbiology Research is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial pathogenesis
  • host–bacteria interactions
  • resistant bacteria
  • pathogen detection
  • vaccine
  • zoonotic

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Published Papers (1 paper)

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Research

18 pages, 921 KiB  
Article
Occurrence and Transfer by Conjugation of Linezolid- Resistance Among Non-Enterococcus faecalis and Enterococcus faecium in Intensive Pig Farms
by Giorgia Piccioni, Andrea Di Cesare, Raffaella Sabatino, Gianluca Corno, Gianmarco Mangiaterra, Daniela Marchis and Barbara Citterio
Microbiol. Res. 2025, 16(8), 180; https://doi.org/10.3390/microbiolres16080180 (registering DOI) - 2 Aug 2025
Abstract
Enterococcus spp. are opportunistic and nosocomial pathogens. Intensive pig farms have been recently described as important hotspots for antibiotic resistance and reservoirs of potentially pathogenic enterococci, including other species than the most known E. faecalis and E. faecium. Here, we identified Linezolid-resistant [...] Read more.
Enterococcus spp. are opportunistic and nosocomial pathogens. Intensive pig farms have been recently described as important hotspots for antibiotic resistance and reservoirs of potentially pathogenic enterococci, including other species than the most known E. faecalis and E. faecium. Here, we identified Linezolid-resistant non-E. faecalis and E. faecium (NFF) Enterococcus strains isolated from different production stages (suckling piglets, weaning pigs, and fatteners) across six intensive pig farms. The transferability of the linezolid-resistance determinants was assessed by bacterial conjugation and strains were also characterized for biofilm production, hemolytic and gelatinase activity. Among 64 identified NFF Enterococcus strains, 27 were resistant to at least three different antibiotic classes and 8/27 specifically to Linezolid. E. gallinarum and E. casseliflavus both transferred their Linezolid resistance determinants to the main pathogenic species E. faecium. Remarkably, this is the first report of the optrA gene transfer from E. casseliflavus to E. faecium by conjugation, which can greatly contribute to the spread of antibiotic resistance genes among pathogenic enterococcal species. The “weaning pigs” stage exhibited a significantly higher number of antibiotic-resistant enterococci than the “fatteners”. These findings highlight the importance of monitoring pig farms as hotspots for the spread of antibiotic-resistant enterococci, especially in the early stages of production. Furthermore, they underscore the significant role of NFF Enterococcus species as carriers of antibiotic resistance genes, even to last-resort antibiotics, which may be transferable to the major enterococcal species. Full article
(This article belongs to the Special Issue Zoonotic Bacteria: Infection, Pathogenesis and Drugs—Second Edition)
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