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AI publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances and Applications in Graph Neural Networks (GNNs)

edited by

Alessandro Rozza

and

Marco Leonardi

submission deadline 10 Nov 2026 | 1 articles | Viewed by 2550 | Submission Open

Keywords: graph neural networks; transfer learning in GNNs; GNN applications

(This special issue belongs to the Section AI Systems: Theory and Applications)

Digital Health: AI-Driven Personalized Healthcare and Applications

edited by

Giovanna Sannino

Laura Verde

and

Salvatore Giugliano

submission deadline 16 Nov 2026 | 2 articles | Viewed by 2629 | Submission Open

Keywords: artificial intelligence; personalized healthcare; digital health; predictive modelling; precision medicine; wearable devices; explainable AI; health informatics; clinical decision support system; federated learning

(This special issue belongs to the Section Medical & Healthcare AI)

Trustworthy AI for Autonomous Cyber Defense: Robustness, Reasoning and Real-Time Assurance

edited by

Fan Liang

and Xing Liu

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1331 | Submission Open

Keywords: autonomous cyber defense; adversarial machine learning; intrusion detection; explainable and certifiable AI; moving target defense; federated/privacy-preserving learning; digital twins; edge/embedded AI; CPS/IoT security; human-in-the-loop assurance

(This special issue belongs to the Section AI in Autonomous Systems)

AI for Smart Aging: Predictive, Assistive, and Humanized Technologies in Elder Care

edited by

Chialun Lo

and ChenChang Wu

submission deadline 30 Nov 2026 | Viewed by 923 | Submission Open

Keywords: smart aging; artificial intelligence in elder care; predictive analytics; assistive robotics; emotion-aware systems; AI companions; gerontechnology; aging in place; cognitive decline detection; human-centered AI; ethical AI in healthcare; digital health for older adults

(This special issue belongs to the Section Medical & Healthcare AI)

AI-Driven Advances in Modern Software Engineering and Web Technologies

edited by Shakeel Ahmad,

Ismet Gocer

Raza Hasan

and

Zuhaib Khan

submission deadline 30 Nov 2026 | Viewed by 378 | Submission Open

Keywords: artificial intelligence; software engineering; web technologies; machine learning; generative AI; sustainable computing; intelligent systems; responsible

(This special issue belongs to the Section AI Systems: Theory and Applications)

Artificial Intelligence and Internet of Things Integration for Smart Cities

edited by

Ke-Lin Du

, Qiaobin Liu and

Di Ao

submission deadline 30 Nov 2026 | Viewed by 159 | Submission Open

Keywords: artificial intelligence; Internet of Things; smart cities; machine learning; deep learning; edge AI; intelligent transportation systems; urban data analytics; smart infrastructure; federated learning; AI and IoT for urban and peri-urban agriculture; smart greenhouses; vertical farming in smart cities; AI-driven resource management; water– energy– food nexus; IoT sensor networks; environmental and agricultural monitoring; smart logistics; urban food supply chains

(This special issue belongs to the Section AI Systems: Theory and Applications)

How Is AI Transforming Education?

edited by Andrej Flogie

submission deadline 15 Dec 2026 | 6 articles | Viewed by 15746 | Submission Open

Keywords: artificial intelligence in education (AIED); transformative learning and teaching; generative artificial intelligence (Gen-AI); AI-driven educational innovation; pedagogical transformation

(This special issue belongs to the Section AI Systems: Theory and Applications)

LLMs and AI Agents in Biomedical and Health Sciences

edited by Zhenhong Hu and

Yingbo Ma

submission deadline 22 Dec 2026 | 1 articles | Viewed by 540 | Submission Open

Keywords: large language models (LLMs); agents; biomedical AI; healthcare AI; clinical decision support; multimodal AI; retrieval-augmented generation (RAG); agentic AI systems; human– AI collaboration; trustworthy and explainable AI

(This special issue belongs to the Section Medical & Healthcare AI)

Harnessing Machine Learning for Intelligent Educational Tools and Learning Analytics

edited by

Jason Zagami

submission deadline 30 Dec 2026 | Viewed by 171 | Submission Open

Keywords: machine learning; learning analytics; intelligent tutoring systems; automated feedback; higher education assessment; explainable AI; fairness; privacy; multimodal analytics; academic integrity

(This special issue belongs to the Section AI Systems: Theory and Applications)

Advances in Quantum Computing and Quantum Machine Learning

edited by

Arslan Munir

submission deadline 31 Dec 2026 | 3 articles | Viewed by 22299 | Submission Open

Keywords: quantum computing; quantum machine learning; hybrid quantum-classical computing; hybrid quantum-classical machine learning; noisy intermediate-scale quantum processing; quantum algorithms; quantum circuits

Deep Learning Technologies and Their Applications in Image Processing, Computer Vision, and Computational Intelligence

edited by

Honggang Chen

and

Chao Ren

submission deadline 31 Dec 2026 | 7 articles | Viewed by 14300 | Submission Open

Keywords: deep learning models and algorithms; machine learning theory and technology; image processing theory and applications; computer graphics and computational photography; computer vision techniques and applications; multimedia technology

Deep Learning Approaches for PHY/MAC Wireless Communication and AI Integration

edited by Eneko Iradier and

Iñigo Bilbao

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1255 | Submission Open

Keywords: deep learning for wireless communications; PHY layer signal processing; MAC layer optimization; AI-enabled wireless networks; cross-layer learning; channel estimation and detection; resource allocation and scheduling; 6G systems; edge intelligence and federated learning

(This special issue belongs to the Section AI Systems: Theory and Applications)

Human–AI Collaboration and Augmented Intelligence: Bridging Theory, Design and Practice

edited by

Phivos Mylonas

, Ioannis Voyiatzis and

Nicolas Tsapatsoulis

submission deadline 31 Dec 2026 | Viewed by 907 | Submission Open

Keywords: human– AI collaboration; augmented intelligence systems; explainable artificial intelligence (XAI); human-in-the-loop machine learning; adaptive and interactive ai applications

Harvesting the Future: AI applications in Precision Agriculture

edited by Ahmed Kayad and

Ahmed Rabia

submission deadline 31 Dec 2026 | Viewed by 273 | Submission Open

Keywords: digital agriculture; yield prediction; plant disease detection; smart irrigation; weeding robots; site-specific crop management

(This special issue belongs to the Section AI Systems: Theory and Applications)

Artificial Intelligence Applications in Logistics and Supply Chain Simulation

edited by

Péter Tamás

submission deadline 15 Jan 2027 | Viewed by 350 | Submission Open

Keywords: artificial intelligence; logistics simulation; supply chain simulation; digital twin; machine learning; reinforcement learning; intelligent agents

(This special issue belongs to the Section AI Systems: Theory and Applications)

AI and Machine Learning in Cancer Multi-Omics: Identification of Biomarkers, Disease-Related Processes and Drug Targets

edited by Graham Ball

submission deadline 15 Jan 2027 | Viewed by 324 | Submission Open

Keywords: artificial intelligence; machine learning; multi-omics integration; biomarker discovery; precision oncology; drug target identification; computational cancer biology

(This special issue belongs to the Section Medical & Healthcare AI)

Intelligent Data-Driven Approaches for Next-Generation Medical Diagnosis and Healthcare Systems

edited by

Paweł Pławiak

and

Jaya Prakash Allam

submission deadline 29 Jan 2027 | 1 articles | Viewed by 1615 | Submission Open

Keywords: artificial intelligence; data-driven medicine; deep learning; explainable AI; medical diagnosis; biomedical signal and image analysis; precision healthcare; edge AI; federated learning; clinical decision support

(This special issue belongs to the Section Medical & Healthcare AI)

Controllable and Reliable AI

edited by Li Xiao, Yongping Xiong and Jingjia Zhang

submission deadline 31 Jan 2027 | 2 articles | Viewed by 7909 | Submission Open

Keywords: computer vision; edge computing; foundation models; integrated sensing and communication; internet of things; ethics and policy

(This special issue belongs to the Section AI Systems: Theory and Applications)

Trustworthy AI, Large Language Models and Blockchain-Enabled Data Intelligence for Secure Smart Environments

edited by

Muhammad Sadiq

, Junwei Liang, Mohammad Sultan Mahmud and

Syed Muhammad Mohsin

submission deadline 31 Jan 2027 | Viewed by 449 | Submission Open

Keywords: trustworthy AI; large language models; multimodal foundation models; generative AI; agentic AI; retrieval-augmented generation; blockchain; big data analytics; data-centric AI; computer vision; privacy-preserving AI; federated learning; edge intelligence; Internet of Things; cyber– physical systems; AI governance; secure smart environments

(This special issue belongs to the Section AI Systems: Theory and Applications)

Human–Robot Interaction and Autonomous Learning: Building Intelligent Robotic Systems

edited by Jian Zhang

submission deadline 31 Jan 2027 | Viewed by 61 | Submission Open

Keywords: multi-robot coordination; communication protocols; swarm robotics; distributed systems; fault tolerance; multi-agent reinforcement learning; human– robot interaction; task allocation; adaptive robotics; dynamic environments

(This special issue belongs to the Section AI in Autonomous Systems)

Computer Vision in Practice: Innovations, Challenges, and Future Directions

edited by

Miguel Angel Cazorla

Carlos Cano-Espinosa

, Carlos Quesada-Granja and Gonzalez-Serrano German

submission deadline 10 Feb 2027 | Viewed by 281 | Submission Open

Keywords: artificial intelligence; AI applications; interdisciplinary research; healthcare; assistive technologies; education; energy

(This special issue belongs to the Section AI Systems: Theory and Applications)

Artificial Intelligence in Service Encounters: Opportunities, Risks, and Consumer Behavior

edited by

Dewen Liu

submission deadline 14 Feb 2027 | Viewed by 299 | Submission Open

Keywords: human– AI interaction; consumer behavior and psychology; trust and transparency; consumer well-being; social sustainability; service robots; ethical AI; behavioral nudging

User Behavior Prediction on Social Media Using Artificial Intelligence

edited by

Liviu-Adrian Cotfas

submission deadline 17 Feb 2027 | Viewed by 539 | Submission Open

Keywords: user behavior prediction; behavioral analytics; social media analysis; artificial intelligence; natural language processing; machine learning; deep learning

(This special issue belongs to the Section AI Systems: Theory and Applications)

Physical AI and Autonomy

edited by

Raivo Sell

and Rahul Razdan

submission deadline 26 Feb 2027 | Viewed by 270 | Submission Open

Keywords: physical AI; autonomous systems; embodied intelligence; validation and verification; safety-critical AI; digital twins; simulation-to-reality transfer; autonomous vehicles; robotics; trustworthy AI

(This special issue belongs to the Section AI in Autonomous Systems)

Privacy Computing and Federated Learning

edited by Yong-Feng Ge

submission deadline 28 Feb 2027 | Viewed by 264 | Submission Open

Keywords: privacy computing; federated learning; differential privacy; secure multi-party computation; homomorphic encryption; privacy-preserving algorithms; machine learning security

Advances in Deep Learning for Air Pollution and Climate Science Research

edited by Alqamah Sayeed and Ahmed Khan Salman

submission deadline 1 Mar 2027 | Viewed by 135 | Submission Open

Keywords: air pollution estimation and forecasting; climate variability and extremes; satellite retrievals for air quality; wildfire smoke detection and exposure mapping; bias correction for CTM and ESM outputs; CTM and ESM emulation; downscaling and super-resolution; data assimilation and inverse modeling; foundation model fine-tuning; explainable AI and uncertainty quantification

(This special issue belongs to the Section AI Systems: Theory and Applications)

AI in Bioinformatics: The Next Frontier in Health Discovery

edited by Gabriella Trucco

submission deadline 10 Mar 2027 | Viewed by 266 | Submission Open

Keywords: high-performance computing; scalable AI; precision medicine; multi-omics integration; deep learning; computational genomics; big data

(This special issue belongs to the Section Medical & Healthcare AI)

AI for Recommendation Systems and Their Applications

edited by

Shoujin Wang

and

Longxiang Shi

submission deadline 19 Mar 2027 | Viewed by 311 | Submission Open

Keywords: AI-powered recommendation models and algorithms; multi-interest; multi-intent; and user behavior modeling; sequential; session-based; and context-aware recommendation; graph neural networks and knowledge-aware recommendation; reinforcement learning and bandit-based recommendation systems; contrastive; self-supervised; and representation learning for recommendation; large language models and foundation models for recommendation; explainable; trustworthy; and fair recommendation systems; privacy-preserving and robust recommendation methods; cross-domain; multi-modal; and multi-task recommendation; recommendation systems for emerging applications (e.g.; healthcare; education; smart manufacturing; cultural heritage; scientific discovery); industrial applications and real-world deployment of AI-based recommendation systems; recommender systems for various applications in real-world domains; e.g.; healthcare; education; agriculture; etc.

(This special issue belongs to the Section AI Systems: Theory and Applications)

Governing Trustworthy AI Outputs in a Sensor-Dense Society: Privacy, Auditability and Responsible Deployment

edited by Yusaku Fujii

submission deadline 31 Mar 2027 | Viewed by 545 | Submission Open

Keywords: privacy governance infrastructure; sensor-rich systems; edge AI; smart cities; smart transportation; output governance; egress control; purpose limitation; least disclosure; audit trail; tamper-evident logging; provenance; traceability; accountability; compliance; verifiable records; transparency reporting; verifiable inference; ZKML; machine unlearning; exception access governance.

(This special issue belongs to the Section AI Systems: Theory and Applications)

AI and Transportation: Pioneering Smart Mobility

edited by Yitong Shang, Kecheng He and Qiang Xing

submission deadline 31 Mar 2027 | Viewed by 308 | Submission Open

Keywords: artificial intelligence; smart mobility; intelligent transportation systems; vehicle-to-grid and smart charging; autonomous vehicles; machine learning and deep learning; Internet of Vehicles

(This special issue belongs to the Section AI in Autonomous Systems)

Agentic AI for Healthcare: Reasoning, Safety, and Clinically Aligned Autonomous Systems

edited by

Abdul Rehman

Faisal Saeed

and Muhammad Mazhar Rathore

submission deadline 31 Mar 2027 | Viewed by 251 | Submission Open

Keywords: agentic AI; healthcare AI; intelligent agents; clinical decision intelligence; multimodal AI; sequential decision making; safe reinforcement learning; human– AI collaboration; constraint-aware optimization; explainable and trustworthy AI; closed-loop clinical systems; real-world clinical validation

(This special issue belongs to the Section Medical & Healthcare AI)

Artificial Intelligence for Robotic Perception and Planning

edited by

Tao Zhang

Jun Li

and Hongyu Wei

submission deadline 9 Apr 2027 | 1 articles | Viewed by 1123 | Submission Open

Keywords: artificial intelligence; robot path planning; motion planning; deep learning; reinforcement learning; simultaneous localization and mapping; visual-and-language navigation and action

(This special issue belongs to the Section AI in Autonomous Systems)

Construction 4.0: The AI-Driven Innovation and Application for Construction Management

edited by Ren-Jye Dzeng

submission deadline 20 Apr 2027 | Viewed by 144 | Submission Open

Keywords: construction management; artificial intelligence (AI); construction management; automation; robotics; site safety; autonomous systems; digital twins; sustainable construction; circular economy; human– AI collaboration

(This special issue belongs to the Section AI Systems: Theory and Applications)

Advances in AI-Driven Perception and Intelligent Control for Autonomous Vehicles

edited by Liang Tong and Rui Zhao

submission deadline 30 Apr 2027 | Viewed by 370 | Submission Open

Keywords: autonomous driving; vehicle detection; intelligent control; motion planning; decision-making; sensor fusion; deep learning; end-to-end systems

(This special issue belongs to the Section AI Systems: Theory and Applications)

AI and Computer Vision in Real-World and Industrial Applications

edited by

Victor García

, David Zorrilla and

Jesús Sánchez-Márquez

submission deadline 30 Apr 2027 | Viewed by 164 | Submission Open

Keywords: artificial intelligence; computer vision; smart manufacturing; industrial automation; applications

(This special issue belongs to the Section AI Systems: Theory and Applications)

Leveraging AI and Blockchain for Smart, Transparent and Resilient Supply Chain Systems

edited by

Milad Baghalzadeh Shishehgarkhaneh

Amer A. Hijazi

and

Ali Al-Ashwal

submission deadline 30 Apr 2027 | Viewed by 105 | Submission Open

Keywords: artificial intelligence (AI); blockchain technology; smart supply chain systems; supply chain resilience; decentralized supply chain management; AI– blockchain integration

(This special issue belongs to the Section AI Systems: Theory and Applications)

Artificial Intelligence in Financial Technology: Advances in Algorithmic Trading, Risk Management, and Computational Finance

edited by

Matloob Khushi

and Rakesh Kumar Sanodiya

submission deadline 30 Apr 2027 | Viewed by 104 | Submission Open

Keywords: algorithmic trading; machine learning in finance; financial risk management; time series forecasting; computational finance

Network Forensics and Cybersecurity Applications

edited by Xiang Zhang and Huan Yan

submission deadline 30 Apr 2027 | Viewed by 83 | Submission Open

Keywords: network forensics; cybersecurity applications; artificial intelligence; cyber-physical systems (CPS); wireless sensing security; 6G-ISAC Physics-Informed Neural Networks (PINNs); intrusion detection; critical infrastructure protection; privacy preservation

(This special issue belongs to the Section AI Systems: Theory and Applications)

Optimizing Smart Manufacturing Using AI Algorithms

edited by Hsinyuan Chen and

Chetan Sharma

submission deadline 1 Jul 2027 | Viewed by 359 | Submission Open

Keywords: artificial intelligence; smart manufacturing; process optimization; predictive maintenance; intelligent production; machine learning; deep learning; reinforcement learning; industrial automation

(This special issue belongs to the Section AI Systems: Theory and Applications)

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