Biomedicines Webinar | Pharmacokinetics and Pharmacogenetics in Treating Infections, 10 May 2024

The new era in systems pharmacology has revolutionized the study of human biology. Its applicability, precise treatment, adequate response, and safety measures are all relevant to medical/clinical practice, particularly in the field of infectious diseases, given the dramatic increase in the prevalence of multi-drug-resistant organisms in the last 10 years.

Due to this background, immediate and appropriate anti-infective therapy—defined as the timely commencement of pharmacological treatment with an appropriate strength for the pathogen(s)—is mandatory in improving the clinical outcomes of infected patients and limiting/preventing the development of resistance.

Consistent and solid evidence is accumulating showing that the successful treatment of severe infections is based on the selection of the most appropriate anti-infective agents that ensure adequate exposure, whilst taking into consideration both the patient’s pathophysiological changes and the physicochemical properties of the drug administered to reach the optimal pharmacokinetic/pharmacodynamic (PK/PD) targets. This is particularly true for antibiotics, since underdosing may result in treatment failure, thereby increasing the likelihood of the development of antimicrobial resistance. The achievement of optimal anti-infective exposure is difficult in clinical practice because most of these drugs are administered according to standard dosing regimens, which do not take into account the pathophysiologic, iatrogenic, and/or genetic factors that are likely to affect both the pharmacokinetics and pharmacodynamics of anti-infective agents in different real-life settings.

Accordingly, in this webinar, we will mainly deal with the main clinical, pharmacologic, and pharmacogenetic sources of variability in the exposure and clinical response to anti-infective agents, with a specific focus on the role of therapeutic drug monitoring and pharmacogenetic testing as reliable diagnostic tools in the daily management of in- and out-patient settings.

Finally, the potential role of fast-track pharmacology at the bedside will also be proposed.

Date: 10 May 2024 at 3.00 p.m. CEST | 9:00 a.m. EDT | 9:00 p.m. CST Asia
Webinar ID: 893 0899 5947
Webinar Secretariat: journal.webinar@mdpi.com
Sciforum webpage: https://sciforum.net/event/Biomedicines-13

Speaker/Presentation	Time in CEST	Time in EDT
Prof. Jessica Cusato Chair Introduction	3:00–3:10 p.m.	9:00–9:10 p.m.
Dr. Dario Cattaneo Pharmacokinetics of Anti-Infectives at the Bedside	3:10–3:30 p.m.	9:10–9:30 p.m.
Prof. Jessica Cusato The Role of Clinical Pharmacogenetics in Infectious Diseases	3:30–3:50 p.m.	9:30–9:50 p.m.
Q&A Session	3:50–4:05 p.m.	9:50–10:05 p.m.
Prof. Jessica Cusato Closing of Webinar	4:05–4:10 p.m.	10:05–10:10 p.m.

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Webinar Chair and Keynote Speakers:

Jessica Cusato (Chair), Department of Medical Sciences, University of Turin, Italy;
Dario Cattaneo, Sacco Hospital, Milan, Italy.