Genes | Top Viewed Papers in 2024–2025

Genes (ISSN: 2073-4425) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to genes, genetics, and genomics. For more information about the journal, please visit the following link: https://www.mdpi.com/journal/genes.

All papers are in an open-access format, granting our readers free and unlimited access to the full text of all the articles published in our journal. We welcome you to read our most top viewed papers published in 2024 and 2025, which are listed below.

1. “A Comprehensive Review of Bioinformatics Tools for Genomic Biomarker Discovery Driving Precision Oncology”
by Alexis J. Clark and James W. Lillard, Jr.
Genes 2024, 15(8), 1036. https://doi.org/10.3390/genes15081036
Available online: https://www.mdpi.com/2073-4425/15/8/1036

2. “Genetic Basis of Breast and Ovarian Cancer: Approaches and Lessons Learnt from Three Decades of Inherited Predisposition Testing”
by Valeria Barili, Enrico Ambrosini, Beatrice Bortesi, Roberta Minari, Erika De Sensi, Ilenia Rita Cannizzaro, Antonietta Taiani, Maria Michiara, Angelica Sikokis, Daniela Boggiani et al.
Genes 2024, 15(2), 219; https://doi.org/10.3390/genes15020219
Available online: https://www.mdpi.com/2073-4425/15/2/219

3. “Beyond the Anticodon: tRNA Core Modifications and Their Impact on Structure, Translation and Stress Adaptation”
by Marcel-Joseph Yared, Agathe Marcelot and Pierre Barraud
Genes 2024, 15(3), 374; https://doi.org/10.3390/genes15030374
Available online: https://doi.org/10.3390/genes15030374

4. “Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome”
by Alejandro Borrego-Ruiz and Juan J. Borrego
Genes 2024, 15(12), 1599; https://doi.org/10.3390/genes15121599
Available online: https://doi.org/10.3390/genes15121599

5. “Understanding the Variability of 22q11.2 Deletion Syndrome: The Role of Epigenetic Factors”
by Francesca Cillo, Emma Coppola, Federico Habetswallner, Francesco Cecere, Laura Pignata, Elisabetta Toriello, Antonio De Rosa, Laura Grilli, Antonio Ammendola, Paolo Salerno et al.
Genes 2024, 15(3), 321; https://doi.org/10.3390/genes15030321
Available online: https://doi.org/10.3390/genes15030321

6. “HERVs: Expression Control Mechanisms and Interactions in Diseases and Human Immunodeficiency Virus Infection”
by Federica Mantovani, Konstantina Kitsou and Gkikas Magiorkinis
Genes 2024, 15(2), 192; https://doi.org/10.3390/genes15020192
Available online: https://doi.org/10.3390/genes15020192

7. “Karyotype Diversification and Chromosome Rearrangements in Squamate Reptiles”
by Marcello Mezzasalma, Rachele Macirella, Gaetano Odierna and Elvira Brunelli
Genes 2024, 15(3), 371; https://doi.org/10.3390/genes15030371
Available online: https://doi.org/10.3390/genes15030371

8. “Hypoxia in the Blue Mussel Mytilus chilensis Induces a Transcriptome Shift Associated with Endoplasmic Reticulum Stress, Metabolism, and Immune Response”
by Milton Montúfar-Romero, Valentina Valenzuela-Muñoz, Diego Valenzuela-Miranda and Cristian Gallardo-Escárate
Genes 2024, 15(6), 658; https://doi.org/10.3390/genes15060658
Available online: https://doi.org/10.3390/genes15060658

9. “A Comparison of Structural Variant Calling from Short-Read and Nanopore-Based Whole-Genome Sequencing Using Optical Genome Mapping as a Benchmark”
by Yang Pei, Melanie Tanguy, Adam Giess, Abhijit Dixit, Louise C. Wilson, Richard J. Gibbons, Stephen R. F. Twigg, Greg Elgar and Andrew O. M. Wilkie
Genes 2024, 15(7), 925; https://doi.org/10.3390/genes15070925
Available online: https://doi.org/10.3390/genes15070925

10. “The Effect of Maternal Diet and Physical Activity on the Epigenome of the Offspring”
by Anastasia Panagiotidou, Christos Chatzakis, Athina Ververi, Makarios Eleftheriades and Alexandros Sotiriadis
Genes 2024, 15(1), 76; https://doi.org/10.3390/genes15010076
Available online: https://doi.org/10.3390/genes15010076

11. “Autism Spectrum Disorder: Genetic Mechanisms and Inheritance Patterns”
by Ilaria La Monica, Maria Rosaria Di Iorio, Antonia Sica, Francesca Rufino, Chiara Sotira,
Lucio Pastore and Barbara Lombardo
Genes 2025, 16(5), 478; https://doi.org/10.3390/genes16050478
Available online: https://doi.org/10.3390/genes16050478

12. “Systematic Review: Fragile X Syndrome Across the Lifespan with a Focus on Genetics, Neurodevelopmental, Behavioral and Psychiatric Associations”
by Ann C. Genovese and Merlin G. Butler
Genes 2025, 16(2), 149; https://doi.org/10.3390/genes16020149
Available online: https://doi.org/10.3390/genes16020149

13. “Genomic and Transcriptomic Approaches Advance the Diagnosis and Prognosis of Neurodegenerative Diseases”
by Zheng Liu and Si-Yuan Song
Genes 2025, 16(2), 135; https://doi.org/10.3390/genes16020135
Available online: https://doi.org/10.3390/genes16020135

14. “Impact of Heavy Metal and Resistance Genes on Antimicrobial Resistance: Ecological and Public Health Implications”
by Carlos G. Sánchez-Corona, Luis Uriel Gonzalez-Avila, Cecilia Hernández-Cortez, Jorge Rojas-Vargas, Graciela Castro-Escarpulli and Hugo G. Castelán-Sánchez
Genes 2025, 16(6), 625; https://doi.org/10.3390/genes16060625
Available online: https://doi.org/10.3390/genes16060625

15. “Comparative Analysis of the Genetic Composition of Minorities in the Carpathian Basin Through Genome-Wide Autosomal Data”
by András Szabó, Katalin Sümegi, Zsolt Bánfai, Kinga Hadzsiev, Ferenc Gallyas, Attila Miseta, Miklós Kásler and Béla Melegh
Genes 2025, 16(5), 607; https://doi.org/10.3390/genes16050607
Available online: https://doi.org/10.3390/genes16050607

16. “Endogenous Retroviruses in Host-Virus Coevolution: From Genomic Domestication to Functional Innovation”
by Ruqi Jiang, Jingjun Zhou, Yue Liu, Guanjin Zhou, Dongdong Fan, Lixin Xiang, Ye Chen
and Jianzhong Shao
Genes 2025, 16(8), 964; https://doi.org/10.3390/genes16080964
Available online: https://doi.org/10.3390/genes16080964

17. “Role of MicroRNAs in Acute Myeloid Leukemia”
by Aneta Wiśnik, Dariusz Jarych, Kinga Krawiec, Piotr Strzałka, Natalia Potocka,
Magdalena Czemerska, Aleksandra Sałagacka-Kubiak, Agnieszka Pluta, Agnieszka Wierzbowska
and Izabela Zawlik
Genes 2025, 16(4), 446; https://doi.org/10.3390/genes16040446
Available online: https://doi.org/10.3390/genes16040446

18. “Barth Syndrome: TAFAZZIN Gene, Cardiologic Aspects, and Mitochondrial Studies—A Comprehensive Narrative Review”
by Consolato M. Sergi
Genes 2025, 16(4), 465; https://doi.org/10.3390/genes16040465
Available online: https://doi.org/10.3390/genes16040465

19. “Identification of Key Genes Associated with Overall Survival in Glioblastoma Multiforme Using TCGA RNA-Seq Expression Data”
by Lilies Handayani, Denis Chegodaev, Ray Steven and Kenji Satou
Genes 2025, 16(7), 755; https://doi.org/10.3390/genes16070755
Available online: https://doi.org/10.3390/genes16070755

20. “Role of MicroRNAs in Acute Myeloid Leukemia”
by Aneta Wiśnik, Dariusz Jarych, Kinga Krawiec, Piotr Strzałka, Natalia Potocka, Magdalena
Czemerska, Aleksandra Sałagacka-Kubiak, Agnieszka Pluta, Agnieszka Wierzbowska and Izabela
Zawlik
Genes 2025, 16(4), 446; https://doi.org/10.3390/genes16040446
Available online: https://doi.org/10.3390/genes16040446

If you are an active researcher in this field and are interested in publishing innovative research, please do not hesitate to contact the Managing Editor, Ms. Jessie Guo (jessie.guo@mdpi.com).