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Med. Sci. Forum, 2025, CiiEM 2025

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6 pages, 186 KiB  
Proceeding Paper
A One Health Perspective on the Clinical, Behavioural, and Environmental Risks of Chronic Proton Pump Inhibitor Use in Older Adults
by Maria Deolinda Auxtero
Med. Sci. Forum 2025, 37(1), 1; https://doi.org/10.3390/msf2025037001 - 18 Aug 2025
Abstract
This study explores the clinical, behavioural, and environmental risks of chronic proton pump inhibitor (PPI) use in older adults through a One Health perspective. Among 246 participants, 32.5% were receiving PPI therapy, with 91.3% on long-term treatment, frequently lacking clear clinical justification. Polypharmacy, [...] Read more.
This study explores the clinical, behavioural, and environmental risks of chronic proton pump inhibitor (PPI) use in older adults through a One Health perspective. Among 246 participants, 32.5% were receiving PPI therapy, with 91.3% on long-term treatment, frequently lacking clear clinical justification. Polypharmacy, drug interactions, and risky lifestyle behaviours were common. Environmental review highlighted the potential persistence of PPI transformation products in water systems, raising concerns about ecological impact and antimicrobial resistance. These findings underscore the urgency of implementing deprescribing strategies, enhancing patient education, and adopting sustainable prescribing practices that align human and environmental health. Full article
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