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International Journal of Translational Medicine, Volume 4, Issue 3

September 2024 - 15 articles

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Articles (15)

  • Review
  • Open Access
2 Citations
10,581 Views
13 Pages

It is well known that mental illness is often the result of genetic susceptibility combined with environmental factors. In this context, it is useful to consider the role that changes in DNA expression, known as epigenetic, can play in the developmen...

  • Article
  • Open Access
2 Citations
3,161 Views
11 Pages

Serum-Derived Macrophage-Activating Factor Exhibits Anti-Tumor Activity via M2-to-M1 Macrophage Reprogramming

  • Tsuyoshi Takara,
  • Rei Takara,
  • Aya Kobayashi,
  • Hina Shirakata,
  • Shinobu Ambai,
  • Yusei Shinohara and
  • Yoshihiro Uto

Many anti-tumor effects of group-specific component-derived macrophage-activating factors (GcMAFs) have been reported; however, the specific mechanisms remain unclear. Controlling tumor-associated macrophages (TAMs) in the tumor microenvironment is e...

  • Review
  • Open Access
3 Citations
3,148 Views
20 Pages

Dual Role of Tissue Factor Pathway Inhibitor 2—A Novel Serodiagnostic Marker for Ovarian Cancer—In Human Cancers

  • Hiroshi Kobayashi,
  • Shogo Imanaka,
  • Sho Matsubara,
  • Hiroshi Shigetomi and
  • Chiharu Yoshimoto

Background: Tissue factor pathway inhibitors (TFPI1 and TFPI2) are ubiquitously distributed in humans and exhibit inhibitory activity against serine proteinases. TFPI1 inhibits the tissue factor (TF)-dependent extrinsic coagulation pathway, while TFP...

  • Review
  • Open Access
4,710 Views
17 Pages

While existing local therapies partially restore vision loss from diabetic retinopathy (DR), there is currently no reliable treatment to prevent the onset or stop the progression of the disease. This review seeks to explore the inflammatory molecular...

  • Review
  • Open Access
3,131 Views
15 Pages

Current Practice in the Diagnosis and Treatment of Localized Gastric Gastrointestinal Stromal Tumors

  • Zachary Lee,
  • Divya Mohanraj,
  • Abraham Sachs,
  • Madhavi Kambam and
  • Sandra DiBrito

Gastric gastrointestinal stromal tumors (GIST) are rare, neuroectodermal tumors primarily residing in the stomach with characteristic genetic mutations. They are often identified using ultrasound and cross-sectional imaging, or they are noted during...

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Int. J. Transl. Med. - ISSN 2673-8937