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Diabetology, Volume 6, Issue 1

January 2025 - 8 articles

Cover Story: Peripheral arterial disease (PAD) is linked to major adverse limb events in patients with diabetes (DM). We identified five biomarkers to predict major adverse limb events, limb loss, diabetic foot ulcers, and vascular intervention. A random forest model was trained using (1) clinical characteristics, (2) a five-protein panel, and (3) combined clinical characteristics with the five-protein panel. Tumor necrosis factor alpha, bone morphogenic protein 10, chemokine, ligand 15/macrophage inflammatory protein 1 delta, matrix metalloprotease 10, and Protein HTRA2 have a significantly higher level of expression in the DM and PAD group. This biomarker panel can be combined with clinical characteristics for improved diagnosis and prognostication of PAD in DM. View this paper
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Articles (8)

  • Article
  • Open Access
1 Citations
2,419 Views
16 Pages
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Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats

  • Ahmed W. Al-Humadi,
  • Carel W. le Roux,
  • Neil G. Docherty,
  • Werd Al-Najim,
  • Martin Tze Wah Kueh,
  • Andreas C. Lazaris and
  • Charis Liapi
Diabetology2025, 6(1), 8;https://doi.org/10.3390/diabetology6010008

20 January 2025

Background: Choline (Ch) deprivation causes kidney injury and dysfunction, and diabetic nephropathy is also known to be a complication of diabetes; thus, this interplay could potentially aggravate diabetic kidney disease. Aim: This study aims to exam...

Full Article
  • Article
  • Open Access
13 Citations
5,016 Views
15 Pages
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Real-World Life Analysis of a Continuous Glucose Monitoring and Smart Insulin Pen System in Type 1 Diabetes: A Cohort Study

  • Paola Pantanetti,
  • Giovanni Cangelosi,
  • Sara Morales Palomares,
  • Gaetano Ferrara,
  • Federico Biondini,
  • Stefano Mancin,
  • Gabriele Caggianelli,
  • Mauro Parozzi,
  • Marco Sguanci and
  • Fabio Petrelli
Diabetology2025, 6(1), 7;https://doi.org/10.3390/diabetology6010007

16 January 2025

Background: Diabetes affects over 460 million people worldwide and represents a growing public health challenge driven largely by dietary and lifestyle factors. While Type 2 diabetes (T2D) is more prevalent, Type 1 diabetes (T1D) presents unique ther...

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  • Article
  • Open Access
2 Citations
2,047 Views
20 Pages
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Bridelia ferruginea Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes

  • Collins Afriyie Appiah,
  • Jennifer Ngounda,
  • Mavis Boakye-Yiadom,
  • Felix Charles Mills-Robertson,
  • Mariette Nel,
  • Rabia Johnson and
  • Corinna Walsh
Diabetology2025, 6(1), 6;https://doi.org/10.3390/diabetology6010006

7 January 2025

Background: It is well-known that persistent hyperglycaemia predisposes individuals with diabetes to oxidative stress. Bridelia ferruginea Benth., a tropical African plant, is known for its antioxidant activity. Methods: This comparative cross-sectio...

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  • Article
  • Open Access
3 Citations
2,315 Views
12 Pages
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All-Cause Mortality Prediction in Subjects with Diabetes Mellitus Using a Machine Learning Model and Shapley Values

  • Oana Mirea,
  • Mostafa Ghelich Oghli,
  • Oana Neagoe,
  • Mihaela Berceanu,
  • Eugen Țieranu,
  • Liviu Moraru,
  • Victor Raicea and
  • Ionuț Donoiu
Diabetology2025, 6(1), 5;https://doi.org/10.3390/diabetology6010005

7 January 2025

Background/Objectives: Diabetes mellitus (DM) is a prevalent disease with an increased risk of complications. Identifying risk factors for mortality in these patients is crucial, as early recognition can facilitate prompt therapeutic intervention. Ma...

Full Article
  • Review
  • Open Access
6 Citations
6,546 Views
13 Pages
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Mediterranean Diet and Metabolic Syndrome

  • Josipa Radić,
  • Marijana Vučković,
  • Andrej Belančić,
  • Hana Đogaš and
  • Mislav Radić
Diabetology2025, 6(1), 4;https://doi.org/10.3390/diabetology6010004

3 January 2025

Metabolic syndrome (MetS) is a major health issue defined by central obesity and at least two more of the following factors: high triglycerides, low high-density lipoprotein (HDL) cholesterol, high blood pressure, and high fasting glucose. Managing M...

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  • Article
  • Open Access
2,595 Views
10 Pages
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Application of NerveCheck Master in the Diagnosis of Diabetic Peripheral Neuropathy

  • Raquel García de la Peña,
  • Mercedes Ortiz Romero,
  • José María Juárez Jiménez and
  • Ana María Rayo Pérez
Diabetology2025, 6(1), 3;https://doi.org/10.3390/diabetology6010003

2 January 2025

Backgraund/Objetive: Diabetic peripheral neuropathy is a condition that affects the motor, sensory, and autonomic fibers of the peripheral nervous system, with distal polyneuropathy being its most common form. Traditional methods for diagnosing senso...

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  • Article
  • Open Access
2 Citations
2,720 Views
18 Pages
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Identification of Inflammatory Biomarkers for Predicting Peripheral Arterial Disease Prognosis in Patients with Diabetes

  • Kian Draper,
  • Ben Li,
  • Muzammil Syed,
  • Farah Shaikh,
  • Abdelrahman Zamzam,
  • Batool Jamal Abuhalimeh,
  • Kharram Rasheed,
  • Houssam K. Younes,
  • Rawand Abdin and
  • Mohammad Qadura
Diabetology2025, 6(1), 2;https://doi.org/10.3390/diabetology6010002

30 December 2024

Background: Peripheral arterial disease (PAD) is known to be strongly linked to major adverse limb events, ultimately leading to an increased risk of limb-threatening conditions. We developed a predictive model using five identified biomarkers to pre...

Full Article
  • Article
  • Open Access
2 Citations
2,149 Views
13 Pages
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Engaging Primary Care Professionals and People at Risk of Type 2 Diabetes in the Design of PREDIABETEXT, a Multifaceted Digital Intervention Aimed at Preventing Type 2 Diabetes: A Qualitative Study

  • Maria Jesús Serrano-Ripoll,
  • Rocío Zamanillo-Campos,
  • Sofía Mira Martínez,
  • Maria Antònia Fiol-deRoque,
  • Narges Malih,
  • Escarlata Angullo-Martínez and
  • Ignacio Ricci-Cabello
Diabetology2025, 6(1), 1;https://doi.org/10.3390/diabetology6010001

27 December 2024

Objectives: This study aims to explore perspectives and opinions from healthcare professionals and people at risk of type 2 diabetes mellitus (T2DM) to inform the design of PREDIABETEXT, a new digital multifaceted intervention to prevent T2DM. Method...

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