Diabetology, Volume 6, Issue 1
2025 January - 8 articles
Cover Story: Peripheral arterial disease (PAD) is linked to major adverse limb events in patients with diabetes (DM). We identified five biomarkers to predict major adverse limb events, limb loss, diabetic foot ulcers, and vascular intervention. A random forest model was trained using (1) clinical characteristics, (2) a five-protein panel, and (3) combined clinical characteristics with the five-protein panel. Tumor necrosis factor alpha, bone morphogenic protein 10, chemokine, ligand 15/macrophage inflammatory protein 1 delta, matrix metalloprotease 10, and Protein HTRA2 have a significantly higher level of expression in the DM and PAD group. This biomarker panel can be combined with clinical characteristics for improved diagnosis and prognostication of PAD in DM. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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