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Endocrines, Volume 4, Issue 3
September 2023 - 13 articles
Cover Story: Located within the testicular interstitium, Leydig cells orchestrate the production of testosterone, a pivotal hormone in male health and reproduction. While luteinizing hormone (LH) is the main regulator of Leydig cell steroidogenesis, many other molecules also play key roles, including growth hormone (GH), prolactin (PRL), growth factors (insulin, IGF, FGF, EGF), vitamin D, and osteocalcin. The dynamic interplay between receptors and ligands initiates a series of cascades, modulating the activity of an array of kinases and transcription factors, steroidogenic gene expression, and ultimately, the fine-tuning of testosterone synthesis. View this paper
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