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Endocrines, Volume 1, Issue 2
December 2020 - 6 articles
Cover Story: MEN1 mutation predisposes patients to multiple endocrine neoplasia type 1 (MEN1), a genetic syndrome associated with the predominant co-occurrence of endocrine tumors. Intriguingly, recent evidence has suggested that MEN1 could also be involved in the development of breast and prostate cancers, two major hormone-related cancers. In this review, we present the currently available data obtained from mouse models and patients, and molecular studies carried out in endocrine and hormone-related cell lines, including, in particular, the physical and functional interactions between the menin protein, encoded by the MEN1 gene, and estrogen receptor α and androgen receptor. The data highlight a complex and multifaceted role of MEN1 in these two types of hormone-dependent cancers. View this paper
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Endocrines - ISSN 2673-396X